https://bsd.neuroinf.jp/w/index.php?action=history&feed=atom&title=3%CE%B1-Hydroxytibolone
3α-Hydroxytibolone - 版の履歴
2026-04-12T10:58:06Z
このウィキのこのページに関する変更履歴
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WikiSysop: 1版 をインポートしました
2025-03-18T10:27:07Z
<p>1版 をインポートしました</p>
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WikiSysop
https://bsd.neuroinf.jp/w/index.php?title=3%CE%B1-Hydroxytibolone&diff=49715&oldid=prev
bsd>حسن علي البط: added Category:Tertiary alcohols using HotCat
2024-07-12T00:52:44Z
<p>added <a href="/w/index.php?title=%E3%82%AB%E3%83%86%E3%82%B4%E3%83%AA:Tertiary_alcohols&action=edit&redlink=1" class="new" title="カテゴリ:Tertiary alcohols (存在しないページ)">Category:Tertiary alcohols</a> using <a href="/w/index.php?title=WP:HC&action=edit&redlink=1" class="new" title="WP:HC (存在しないページ)">HotCat</a></p>
<p><b>新規ページ</b></p><div>{{Short description|Chemical compound}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = (3''R'',7''R'',8''R'',9''S'',13''S'',14''S'',17''R'')-17-Ethynyl-7,13-dimethyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1''H''-cyclopenta[''a'']phenanthrene-3,17-diol<br />
| image = 3α-Hydroxytibolone.svg<br />
| width = 225px<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration = <br />
| class = <br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!-- Identifiers --><br />
| CAS_number_Ref = <br />
| CAS_number = 100239-44-9<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| PubChem = 10087021<br />
| IUPHAR_ligand = <br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 8262558<br />
| UNII = 37T303O94A<br />
| KEGG = <br />
| ChEBI = <br />
| ChEMBL = <br />
| synonyms = ORG-4094; 7α-Methyl-17α-ethynylestr-5(10)-ene-3α,17β-diol<br />
<br />
<!--Chemical data--><br />
| C=21 | H=30 | O=2<br />
| SMILES = C[C@@H]1CC2=C(CC[C@H](C2)O)[C@@H]3[C@@H]1[C@@H]4CC[C@]([C@]4(CC3)C)(C#C)O<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C21H30O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,15,17-19,22-23H,5-12H2,2-3H3/t13-,15-,17-,18+,19-,20+,21+/m1/s1<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = YLEUWNOTNJZCBN-CZTKNSHGSA-N<br />
}}<br />
<br />
'''3α-Hydroxytibolone''' (developmental code name '''ORG-4094''') is a [[synthetic compound|synthetic]] [[steroid]]al [[estrogen (medication)|estrogen]] which was never marketed.<ref name="Kuhl2005">{{cite journal|last1=Kuhl|first1=H|title=Pharmacology of estrogens and progestogens: influence of different routes of administration|journal=Climacteric|volume=8|issue=sup1|year=2005|pages=3–63|issn=1369-7137|doi=10.1080/13697130500148875|pmid=16112947|s2cid=24616324}}</ref><ref name="pmid19464167">{{cite journal | vauthors = Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T | title = Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites | journal = J. Steroid Biochem. Mol. Biol. | volume = 116 | issue = 1–2 | pages = 8–14 | year = 2009 | pmid = 19464167 | doi = 10.1016/j.jsbmb.2009.03.008 | s2cid = 18346113 | url = http://www.hal.inserm.fr/inserm-00396319/document}}</ref> Along with [[3β-hydroxytibolone]] and [[δ4-tibolone|δ<sup>4</sup>-tibolone]], it is a major [[active metabolite]] of [[tibolone]], and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the [[estrogen (medication)|estrogen]]ic activity of tibolone.<ref name="Kuhl2005" /><ref name="pmid19464167" /><br />
<br />
==References==<br />
{{Reflist}}<br />
<br />
<br />
{{Estrogen receptor modulators}}<br />
<br />
{{DEFAULTSORT:Hydroxytibolone, 3α-}}<br />
<br />
[[Category:Abandoned drugs]]<br />
[[Category:Alkene derivatives]]<br />
[[Category:Ethynyl compounds]]<br />
[[Category:Diols]]<br />
[[Category:Estranes]]<br />
[[Category:Human drug metabolites]]<br />
[[Category:Synthetic estrogens]]<br />
[[Category:Secondary alcohols]]<br />
[[Category:Tertiary alcohols]]<br />
<br />
<br />
{{Genito-urinary-drug-stub}}<br />
{{Steroid-stub}}</div>
bsd>حسن علي البط