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Ent-Estradiol - 版の履歴
2026-04-12T10:53:41Z
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WikiSysop: 1版 をインポートしました
2025-03-18T10:29:09Z
<p>1版 をインポートしました</p>
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bsd>JWBE: removed Category:Phenols; added Category:Hydroxyarenes using HotCat
2024-10-21T12:46:19Z
<p>removed <a href="/w/index.php?title=%E3%82%AB%E3%83%86%E3%82%B4%E3%83%AA:Phenols&action=edit&redlink=1" class="new" title="カテゴリ:Phenols (存在しないページ)">Category:Phenols</a>; added <a href="/w/index.php?title=%E3%82%AB%E3%83%86%E3%82%B4%E3%83%AA:Hydroxyarenes&action=edit&redlink=1" class="new" title="カテゴリ:Hydroxyarenes (存在しないページ)">Category:Hydroxyarenes</a> using <a href="/w/index.php?title=WP:HC&action=edit&redlink=1" class="new" title="WP:HC (存在しないページ)">HotCat</a></p>
<p><b>新規ページ</b></p><div>{{Short description|Chemical compound}}<br />
{{DISPLAYTITLE:''ent''-Estradiol}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = (8''S'',9''R'',13''R'',14''R'',17''R'')-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthrene-3,17-diol<br />
| image = ent-Estradiol.svg<br />
| width = <br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration = <br />
| class = [[Estrogen (medication)|Estrogen]]<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!-- Identifiers --><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 3736-22-9<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = VW299DJ6U7<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| PubChem = 667515<br />
| IUPHAR_ligand = <br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = <br />
| KEGG = <br />
| ChEBI = <br />
| ChEMBL = <br />
| synonyms = ''ent''-E2; 1-Estradiol; 1-E2<br />
<br />
<!--Chemical data--><br />
| C=18 | H=24 | O=2 <br />
| SMILES = C[C@@]12CC[C@@H]3[C@@H]([C@H]1CC[C@H]2O)CCC4=C3C=CC(=C4)O<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = VOXZDWNPVJITMN-QXDIGNSFSA-N<br />
}}<br />
<br />
'''''ent''-Estradiol''' ('''''ent''-E2'''), or '''1-estradiol''' ('''1-E2'''), is an [[estrogen (medication)|estrogen]] and the 1-[[enantiomorph]] of [[estradiol (medication)|estradiol]].<ref name="pmid5821989">{{cite journal | vauthors = Edgren RA, Jones RC | title = An anti-estradiol effect of ent-estradiol-17beta (1-estradiol) | journal = Steroids | volume = 14 | issue = 3 | pages = 335–41 | date = September 1969 | pmid = 5821989 | doi = 10.1016/0039-128x(69)90021-x }}</ref><ref name="pmid4347201">{{cite journal | vauthors = Terenius L, Ljungkvist I | title = Aspects on the mode of action of antiestrogens and antiprogestogens | journal = Gynecol Invest | volume = 3 | issue = 1 | pages = 96–107 | date = 1972 | pmid = 4347201 | doi = 10.1159/000301746 }}</ref><ref name="pmid5104534">{{cite journal | vauthors = Terenius L | title = The Allen-Doisy test for estrogens reinvestigated | journal = Steroids | volume = 17 | issue = 6 | pages = 653–61 | date = June 1971 | pmid = 5104534 | doi = 10.1016/0039-128x(71)90081-x }}</ref> It is a so-called "short-acting" or "impeded" estrogen, similarly to [[estriol (medication)|estriol]], [[alfatradiol|17α-estradiol]], and [[dimethylstilbestrol]].<ref name="pmid5821989" /><ref name="pmid4347201" /><ref name="pmid5104534" /><br />
<br />
==References==<br />
{{Reflist}}<br />
<br />
<br />
{{Estrogen receptor modulators}}<br />
<br />
{{DEFAULTSORT:Estradiol, ent-}}<br />
<br />
[[Category:Abandoned drugs]]<br />
[[Category:Secondary alcohols]]<br />
[[Category:Estranes]]<br />
[[Category:Estrogens]]<br />
[[Category:Hydroxyarenes]]<br />
<br />
<br />
{{Steroid-stub}}<br />
{{Genito-urinary-drug-stub}}</div>
bsd>JWBE