https://bsd.neuroinf.jp/w/index.php?action=history&feed=atom&title=Methylpiperidinopyrazole
Methylpiperidinopyrazole - 版の履歴
2026-04-12T10:58:06Z
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WikiSysop: 1版 をインポートしました
2025-03-18T10:32:29Z
<p>1版 をインポートしました</p>
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bsd>JWBE: removed Category:Phenols; added Category:4-Hydroxyphenyl compounds using HotCat
2024-10-21T16:27:38Z
<p>removed <a href="/w/index.php?title=%E3%82%AB%E3%83%86%E3%82%B4%E3%83%AA:Phenols&action=edit&redlink=1" class="new" title="カテゴリ:Phenols (存在しないページ)">Category:Phenols</a>; added <a href="/w/index.php?title=%E3%82%AB%E3%83%86%E3%82%B4%E3%83%AA:4-Hydroxyphenyl_compounds&action=edit&redlink=1" class="new" title="カテゴリ:4-Hydroxyphenyl compounds (存在しないページ)">Category:4-Hydroxyphenyl compounds</a> using <a href="/w/index.php?title=WP:HC&action=edit&redlink=1" class="new" title="WP:HC (存在しないページ)">HotCat</a></p>
<p><b>新規ページ</b></p><div>{{short description|Chemical compound}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = 4-[2-(4-hydroxyphenyl)-4-methyl-3-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one<br />
| image = Methylpiperidinopyrazole.svg<br />
| width =<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration =<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion =<br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = <br />
| CAS_number = 289726-02-9<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 6604927<br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 5037183<br />
<br />
<!--Chemical data--><br />
| C=29 | H=31 | N=3 | O=3<br />
| smiles = CC1=C(N(NC1=C2C=CC(=O)C=C2)C3=CC=C(C=C3)O)C4=CC=C(C=C4)OCCN5CCCCC5<br />
| StdInChI = 1S/C29H31N3O3/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31/h5-16,30,34H,2-4,17-20H2,1H3<br />
| StdInChIKey = PFTIONINVMINHE-UHFFFAOYSA-N<br />
| synonyms = <br />
}}<br />
<br />
'''Methylpiperidinopyrazole''' ('''MPP''') is a [[synthetic compound|synthetic]], [[nonsteroidal]], and highly selective [[receptor antagonist|antagonist]] of [[Estrogen receptor alpha|ERα]] that is used in [[scientific research]] to study the function of this [[receptor (biochemistry)|receptor]].<ref name="pmid11861516">{{cite journal | vauthors = Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, Katzenellenbogen BS | title = Antagonists selective for estrogen receptor alpha | journal = Endocrinology | volume = 143 | issue = 3 | pages = 941–7 | date = March 2002 | pmid = 11861516 | doi = 10.1210/endo.143.3.8704 | doi-access = free }}</ref><ref name="pmid19014882">{{cite journal | vauthors = Zhou HB, Carlson KE, Stossi F, Katzenellenbogen BS, Katzenellenbogen JA | title = Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity | journal = Bioorganic & Medicinal Chemistry Letters | volume = 19 | issue = 1 | pages = 108–10 | date = January 2009 | pmid = 19014882 | pmc = 2711511 | doi = 10.1016/j.bmcl.2008.11.006 }}</ref> It has 200-fold selectivity for ERα over [[ERβ]] and 1000-fold selectivity for blocking ERα-mediated gene transcription relative to that of ERβ.<ref name="OttowWeinmann2008">{{cite book| vauthors = Ottow E, Weinmann H |title=Nuclear Receptors as Drug Targets|url=https://books.google.com/books?id=iATfLbPgRugC&pg=PA50|date=8 September 2008|publisher=John Wiley & Sons|isbn=978-3-527-62330-3|pages=50–}}</ref><br />
<br />
==See also==<br />
* [[Glyceollin]]<br />
* [[Propylpyrazoletriol]] (PPT)<br />
* [[Diarylpropionitrile]] (DPN)<br />
* [[Prinaberel]] (ERB-041)<br />
* [[Liquiritigenin]]<br />
* [[Menerba]]<br />
* [[PHTPP]]<br />
* [[(R,R)-Tetrahydrochrysene]] ((R,R)-THC)<br />
<br />
==References==<br />
{{reflist|30em}}<br />
<br />
{{Estrogenics}}<br />
<br />
[[Category:Antiestrogens]]<br />
[[Category:1-Piperidinyl compounds]]<br />
[[Category:Phenol ethers]]<br />
[[Category:4-Hydroxyphenyl compounds]]<br />
[[Category:Pyrazoles]]<br />
<br />
{{genito-urinary-drug-stub}}</div>
bsd>JWBE