テンプレート:PBB/6262

Ryanodine receptor 2 (cardiac)
Identifiers
Symbols	RYR2; ARVC2; ARVD2; RYR-2; RyR; VTSIP
External IDs	OMIM: 180902 MGI: 99685 HomoloGene: 37423 IUPHAR: RyR2 GeneCards: RYR2 Gene
Gene Ontology Molecular function • intracellular ligand-gated calcium channel activity • ryanodine-sensitive calcium-release channel activity • calcium channel activity • calcium ion binding • protein binding • calmodulin binding • calmodulin binding • calcium-release channel activity • protein kinase A catalytic subunit binding • protein kinase A regulatory subunit binding • identical protein binding • protein self-association • suramin binding Cellular component • plasma membrane enriched fraction • plasma membrane • junctional sarcoplasmic reticulum membrane • sarcoplasmic reticulum • Z disc • sarcoplasmic reticulum membrane • sarcoplasmic reticulum membrane • calcium channel complex Biological process • response to hypoxia • embryonic heart tube morphogenesis • detection of calcium ion • calcium ion transport • cellular calcium ion homeostasis • induction of apoptosis by ionic changes • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • calcium-mediated signaling • BMP signaling pathway • response to caffeine • release of sequestered calcium ion into cytosol • cytosolic calcium ion homeostasis • response to redox state • cardiac muscle contraction • canonical Wnt receptor signaling pathway • calcium ion transport into cytosol • sarcoplasmic reticulum calcium ion transport • calcium ion transmembrane transport • cellular response to caffeine • regulation of ventricular cardiac muscle cell action potential • Purkinje myocyte to ventricular cardiac muscle cell signaling • positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6262	20191
Ensembl	ENSG00000198626	ENSMUSG00000021313
UniProt	Q92736	E9Q401
RefSeq (mRNA)	NM_001035.2	NM_023868.2
RefSeq (protein)	NP_001026.2	NP_076357.2
Location (UCSC)	Chr 1: 237.21 – 238.13 Mb	Chr 13: 11.55 – 12.11 Mb
PubMed search	[1]	[2]