テンプレート:PBB/6774

Signal transducer and activator of transcription 3 (acute-phase response factor)
PDB rendering based on 1bg1.
Available structures PDB 1bg1​
Identifiers
Symbols	STAT3; APRF; HIES
External IDs	OMIM: 102582 MGI: 103038 HomoloGene: 7960 GeneCards: STAT3 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • signal transducer activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • calcium ion binding • protein binding • transcription factor binding • protein kinase binding • CCR5 chemokine receptor binding • glucocorticoid receptor binding • sequence-specific DNA binding • transcription regulatory region DNA binding • protein dimerization activity Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • plasma membrane Biological process • negative regulation of transcription from RNA polymerase II promoter • temperature homeostasis • eye photoreceptor cell differentiation • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • protein import into nucleus • cellular component movement • acute-phase response • signal transduction • JAK-STAT cascade • nervous system development • cell proliferation • response to organic cyclic compound • virus-host interaction • cytokine-mediated signaling pathway • sexual reproduction • intracellular receptor mediated signaling pathway • response to estradiol stimulus • cellular response to hormone stimulus • regulation of multicellular organism growth • response to drug • glucose homeostasis • eating behavior • response to ethanol • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • nerve growth factor receptor signaling pathway • astrocyte differentiation • radial glial cell differentiation • growth hormone receptor signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • interleukin-6-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6774	20848
Ensembl	ENSG00000168610	ENSMUSG00000004040
UniProt	P40763	P42227
RefSeq (mRNA)	NM_003150.3	NM_011486.4
RefSeq (protein)	NP_003141.2	NP_035616.1
Location (UCSC)	Chr 17: 40.47 – 40.54 Mb	Chr 11: 100.89 – 100.94 Mb
PubMed search	[1]	[2]