「テスト」の版間の差分
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酵素
別名
主な基質
局在（過剰発現系）
関連疾患
DHHC1
ZDHHC1
ER
DHHC2
ZDHHC2
PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1
ER/ゴルジ体
癌
DHHC3
PSD95, SNAP25, Gαs, GABAAγ2, eNOS,
ゴルジ体
DHHC4
ZDHHC4
BACE1
ゴルジ体
DHHC5
ZDHHC5
STREX
DHHC6
ZDHHC6
DHHC7
ZDHHC7
PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS
ゴルジ体
DHHC8
ZDHHC8
PSD95, SNAP25, eNOS, paralemmin-1
ゴルジ体
統合失調症
DHHC9
ZDHHC9
H-RAS, N-Ras
ER/ゴルジ体
癌、X連鎖神経遅滞
DHHC10
ZDHHC11
ER
DHHC11
ZDHHC23
NIDD
ER
癌
DHHC12
ZDHHC12
ABC transporter A1
ER/ゴルジ体
DHHC13
ZDHHC24
huntingtin
ER
DHHC14
ZDHHC14
ER
DHHC15
ZDHHC15
PSD95, GAP43, GABAAγ2, BACE1, CD151
ゴルジ体
X連鎖神経遅滞
DHHC16
ZDHHC16
ER
DHHC17
SNAP25, huntingtin,
ゴルジ体
ハンチントン病、癌
DHHC18
ZDHHC18
ゴルジ体
DHHC19
ZDHHC19
R-Ras
ER
DHHC20
ZDHHC20
BACE1, ABC transporter 1
細胞膜
DHHC21
ZDHHC21
eNOS, Lck, Fyn, ABC transporter 1
細胞膜
DHHC22
ZDHHC13
ER/ゴルジ体
DHHC23
ZDHHC25
ZDHHC22
細編集の要約なし |
細編集の要約なし |
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{| cellspacing="1" cellpadding="1" border="1" style="width: | {| cellspacing="1" cellpadding="1" border="1" style="width: 619px; height: 1446px;" | ||
|+ | |+ 表1 主なS-パルミトイル化タンパク質<br> | ||
表1 主なS-パルミトイル化タンパク質<br> | |||
{| cellspacing="1" cellpadding="1" border="1" style="width: 689px; height: 451px;" | {| cellspacing="1" cellpadding="1" border="1" style="width: 689px; height: 451px;" | ||
|- | |- | ||
| ファミリー<br> | | ファミリー<br> | ||
| 主な例<br> | | 主な例<br> | ||
|- | |- | ||
| '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br> | | '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br> | ||
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br> | | <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br> | ||
|- | |- | ||
| | | | ||
'''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br> | '''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br> | ||
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR | | GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR | ||
|- | |- | ||
| '''Adaptor, Scaffold'''<br> | | '''Adaptor, Scaffold'''<br> | ||
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br> | | PSD95, PSD93α/β, GRIP1/2, Delphilin<br> | ||
|- | |- | ||
| '''Viral protein'''<br> | | '''Viral protein'''<br> | ||
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br> | | Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br> | ||
|- | |- | ||
| '''N-palmitoylated protein'''<br> | | '''N-palmitoylated protein'''<br> | ||
| Sonic Hedgehog, Wnt, Ghrelin <br> | | Sonic Hedgehog, Wnt, Ghrelin <br> | ||
|} | |} | ||
<br> | <br> | ||
<br> | |||
表２ パルミチルトランスフェラーゼ | |||
|- | |- | ||
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|} | |} | ||
| <br> | ||
<br> | |||
2012年1月20日 (金) 14:02時点における版
| ファミリー |
主な例 |
| Signalling protein Small GTPase Gα subunit Src family Others |
H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10 Gαs, Gαq, Gαi2 Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2 |
|
Transmembrane |
GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1 Rhodopsin, β2-adrenergic receptor, Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC EAAT1, EAAT3 MT1-MMP PLP, GPM6A β-secretase, Nicastrin Fas, NGFR |
| Adaptor, Scaffold |
PSD95, PSD93α/β, GRIP1/2, Delphilin |
| Viral protein |
Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160 |
| N-palmitoylated protein |
Sonic Hedgehog, Wnt, Ghrelin |
表２ パルミチルトランスフェラーゼ
ZDHHC3
GODZ
NIDD
ZDHHC17
HIP14