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1行目: 1行目:
{| class="wikitable"
{| class="wikitable"
|+Tyrosine Kinases
|+チロシンキナーゼ
!colspan="3" |[[受容体チロシンキナーゼ]] (EC 2.7.10.2)
|-
!rowspan="7"| [[成長因子受容体]]
!rowspan="7"| [[成長因子受容体]]
||[[ErbB|EGF receptor family]]||[[Epidermal growth factor receptor|EGFR]], [[HER2/neu|ERBB2]], [[ERBB3]], [[ERBB4]]
||[[ErbB|上皮成長因子受容体ファミリー]]||[[上皮成長因子受容体|EGFR]], [[HER2/neu|ERBB2]], [[ERBB3]], [[ERBB4]]
|-
|-
|[[Insulin receptor]] family||[[Insulin-like growth factor 1 receptor|IGF1R]], [[Insulin receptor|INSR]], [[INSRR]]
|[[Insulin受容体]]ファミリー||[[Insulin-like growth factor 1受容体|IGF1R]], [[Insulin受容体|INSR]], [[INSRR]]
|-
|-
|[[RTK class III|PDGF receptor family]]|| [[Colony stimulating factor 1 receptor|CSF1R]], [[CD135|FLT3]], [[CD117|KIT]], [[platelet-derived growth factor receptor|PDGFR]] ([[PDGFRA]], [[PDGFRB]])
|[[RTK class III|PDGF受容体ファミリー]]|| [[Colony stimulating factor 1受容体|CSF1R]], [[CD135|FLT3]], [[CD117|KIT]], [[platelet-derived growth factor受容体|PDGFR]] ([[PDGFRA]], [[PDGFRB]])
|-
|-
|[[Fibroblast growth factor receptor|FGF receptor]] family
|[[Fibroblast growth factor受容体|FGF受容体]]ファミリー
|[[Fibroblast growth factor receptor 1|FGFR1]], [[Fibroblast growth factor receptor 2|FGFR2]], [[Fibroblast growth factor receptor 3|FGFR3]], [[Fibroblast growth factor receptor 4|FGFR4]]
|[[Fibroblast growth factor受容体 1|FGFR1]], [[Fibroblast growth factor受容体 2|FGFR2]], [[Fibroblast growth factor受容体 3|FGFR3]], [[Fibroblast growth factor受容体 4|FGFR4]]
|-
|-
| [[VEGF receptors]] family
| [[VEGF受容体s]]ファミリー
| [[FLT1|VEGFR1]], [[Kinase insert domain receptor|VEGFR2]], [[VEGFR3]], [[VEGFR4]]
| [[FLT1|VEGFR1]], [[Kinase insert domain受容体|VEGFR2]], [[VEGFR3]], [[VEGFR4]]
|-
|-
| [[C-Met|HGF receptor]] family
| [[C-Met|HGF受容体]]ファミリー
|[[C-Met|MET]], [[MST1R|RON]]
|[[C-Met|MET]], [[MST1R|RON]]
|-
|-
| [[Trk receptor]] family
| [[Trk受容体]]ファミリー
|[[TrkA receptor|NTRK1]], [[NTRK2]], [[NTRK3]]
|[[TrkA受容体|NTRK1]], [[NTRK2]], [[NTRK3]]
|-
|-
!colspan="2"|[[Ephrin receptor|EPH receptor]] family
!colspan="2"|[[Ephrin受容体|EPH受容体]]ファミリー
|[[EPH receptor A1|EPHA1]], [[EPH receptor A2|EPHA2]], [[EPH receptor A3|EPHA3]], [[EPH receptor A4|EPHA4]], [[EPH receptor A5|EPHA5]], [[EPHA6]], [[EPHA7]], [[EPHA8]], [[EPH receptor B1|EPHB1]], [[EPH receptor B2|EPHB2]], [[EPHB3]], [[EPH receptor B4|EPHB4]], [[EPHB5]], [[EPHB6]], [[EPHX]]
|[[EPH受容体 A1|EPHA1]], [[EPH受容体 A2|EPHA2]], [[EPH受容体 A3|EPHA3]], [[EPH受容体 A4|EPHA4]], [[EPH受容体 A5|EPHA5]], [[EPHA6]], [[EPHA7]], [[EPHA8]], [[EPH受容体 B1|EPHB1]], [[EPH受容体 B2|EPHB2]], [[EPHB3]], [[EPH受容体 B4|EPHB4]], [[EPHB5]], [[EPHB6]], [[EPHX]]
|-
|-
!colspan="2"|[[Leukocyte receptor tyrosine kinase|LTK receptor]] family
!colspan="2"|[[Leukocyte受容体 チロシンキナーゼ|LTK受容体]]ファミリー
|, [[Leukocyte receptor tyrosine kinase|LTK]], [[Anaplastic lymphoma kinase|ALK]]
|[[Leukocyte受容体 チロシンキナーゼ|LTK]], [[Anaplastic lymphoma kinase|ALK]]
|-
|-
!colspan="2"|[[Angiopoietin receptor|TIE receptor]] family
!colspan="2"|[[Angiopoietin受容体|TIE受容体]]ファミリー
|[[TIE1|TIE]], [[TEK tyrosine kinase|TEK]]
|[[TIE1|TIE]], [[TEK チロシンキナーゼ|TEK]]
|-
|-
!colspan="2"|[[Receptor tyrosine kinase-like orphan receptor|ROR receptor]] family
!colspan="2"|[[受容体チロシンキナーゼ様オーファン受容体|ROR受容体]]ファミリー
|[[ROR1]], [[ROR2]]
|[[ROR1]], [[ROR2]]
|-
|-
!colspan="2"| [[DDR1|DDR receptor]] family
!colspan="2"| [[DDR1|DDR受容体]]ファミリー
| list12  = [[DDR1]], [[Discoidin domain-containing receptor 2|DDR2]]
|[[DDR1]], [[Discoidin domain-containing受容体 2|DDR2]]
|-
|-
!colspan="2"| [[PTK7|PTK7 receptor]] family
!colspan="2"| [[PTK7|PTK7受容体]]ファミリー
|[[PTK7]]
|[[PTK7]]
|-
|-
!colspan="2"|[[related to receptor tyrosine kinase|RYK receptor]] family
!colspan="2"|[[related to受容体 チロシンキナーゼ|RYK受容体]]ファミリー
|[[related to receptor tyrosine kinase|RYK]]
|[[related to受容体 チロシンキナーゼ|RYK]]
|-
|-
!colspan="2"|[[MuSK protein|MuSK receptor]] family
!colspan="2"|[[MuSK protein|MuSK受容体]]ファミリー
|[[MuSK protein|MUSK]]
|[[MuSK protein|MUSK]]
|-
|-
!colspan="2"|[[ROS1 (gene)|ROS receptor]] family
!colspan="2"|[[ROS1 (gene)|ROS受容体]]ファミリー
|[[ROS1 (gene)|ROS1]]
|[[ROS1 (gene)|ROS1]]
|-
|-
!colspan="2"|[[AATK|AATYK receptor]] family
!colspan="2"|[[AATK|AATYK受容体]]ファミリー
|[[AATK|AATYK]], [[LMTK2|AATYK2]], [[AATYK3]]
|[[AATK|AATYK]], [[LMTK2|AATYK2]], [[AATYK3]]
|-
|-
!colspan="2"| [[AXL receptor tyrosine kinase|AXL receptor]] family
!colspan="2"| [[AXL受容体 チロシンキナーゼ|AXL受容体]]ファミリー
| [[AXL receptor tyrosine kinase|AXL]], [[MERTK|MER]], [[TYRO3]]
| [[AXL受容体 チロシンキナーゼ|AXL]], [[MERTK|MER]], [[TYRO3]]
|-
|-
!colspan="2"|[[RET proto-oncogene|RET receptor]] family
!colspan="2"|[[RET proto-oncogene|RET受容体]]ファミリー
|[[RET proto-oncogene|RET]]
|[[RET proto-oncogene|RET]]
|-
|-
59行目: 61行目:
|[[STYK1]]
|[[STYK1]]
|-
|-
!colspan="3" |[[Non-receptor tyrosine kinase]]s (EC 2.7.10.2)
!colspan="3" |[[Non-受容体 チロシンキナーゼ]]s (EC 2.7.10.2)
|-
|-
|[[Abl gene|ABL]] family
!colspan="2"|[[Abl gene|ABL]]ファミリー
| [[Abl gene|ABL1]], [[ABL2|ARG]]
| [[Abl gene|ABL1]], [[ABL2|ARG]]
|-
|-
|[[TNK2|ACK]] family
!colspan="2"|[[TNK2|ACK]]ファミリー
|[[TNK2|ACK1]], [[TNK1]]
|[[TNK2|ACK1]], [[TNK1]]
|-
|-
|[[C-src tyrosine kinase|CSK]] family
!colspan="2"|[[C-src チロシンキナーゼ|CSK]]ファミリー
| [[C-src tyrosine kinase|CSK]], [[Megakaryocyte-associated tyrosine kinase|MATK]]
| [[C-src チロシンキナーゼ|CSK]], [[Megakaryocyte-associated チロシンキナーゼ|MATK]]
|-
|-
| [[PTK2|FAK]] family
!colspan="2"| [[PTK2|FAK]]ファミリー
| [[PTK2|FAK]], [[PTK2B|PYK2]]
| [[PTK2|FAK]], [[PTK2B|PYK2]]
|-
|-
| [[Feline sarcoma oncogene|FES]] family
!colspan="2"| [[Feline sarcoma oncogene|FES]]ファミリー
|[[Feline sarcoma oncogene|FES]], [[FER (gene)|FER]]
|[[Feline sarcoma oncogene|FES]], [[FER (gene)|FER]]
|-
|-
| [[Fyn-related kinase|FRK]] family
!colspan="2"| [[Fyn-related kinase|FRK]]ファミリー
| [[Fyn-related kinase|FRK]], [[PTK6|BRK]], [[SRMS (gene)|SRMS]]
| [[Fyn-related kinase|FRK]], [[PTK6|BRK]], [[SRMS (gene)|SRMS]]
|-
|-
|[[Janus kinase|JAK]] family
!colspan="2"|[[Janus kinase|JAK]]ファミリー
|[[Janus kinase 1|JAK1]], [[Janus kinase 2|JAK2]], [[Janus kinase 3|JAK3]], [[Tyrosine kinase 2|TYK2]]
|[[Janus kinase 1|JAK1]], [[Janus kinase 2|JAK2]], [[Janus kinase 3|JAK3]], [[チロシンキナーゼ 2|TYK2]]
|-
|-
|[[SRC-A]] family
!colspan="2"|[[SRC-A]]ファミリー
|[[Src (gene)|SRC]], [[FGR (gene)|FGR]], [[FYN]], [[YES1]]
|[[Src (gene)|SRC]], [[FGR (gene)|FGR]], [[FYN]], [[YES1]]
|-
|-
|[[SRC-B]] family
!colspan="2"|[[SRC-B]]ファミリー
|[[Tyrosine-protein kinase BLK|BLK]], [[HCK]], [[Lck|LCK]]
|[[Tyrosine-protein kinase BLK|BLK]], [[HCK]], [[Lck|LCK]], [[LYN]]
, [[LYN]]
|-
|-
|[[TEC (gene)|TEC]] family
!colspan="2"|[[TEC (gene)|TEC]]ファミリー
|[[TEC (gene)|TEC]], [[BMX (gene)|BMX]], [[Bruton's tyrosine kinase|BTK]], [[ITK (gene)|ITK]], [[TXK (gene)|TXK]]
|[[TEC (gene)|TEC]], [[BMX (gene)|BMX]], [[Bruton's チロシンキナーゼ|BTK]], [[ITK (gene)|ITK]], [[TXK (gene)|TXK]]
|-
|-
|[[Syk|SYK]] family
!colspan="2"|[[Syk|SYK]]ファミリー
|[[Syk|SYK]], [[ZAP-70|ZAP70]]
|[[Syk|SYK]], [[ZAP-70|ZAP70]]
}
|}

2013年4月12日 (金) 08:52時点における版

チロシンキナーゼ
受容体チロシンキナーゼ (EC 2.7.10.2)
成長因子受容体 上皮成長因子受容体ファミリー EGFR, ERBB2, ERBB3, ERBB4
Insulin受容体ファミリー IGF1R, INSR, INSRR
PDGF受容体ファミリー CSF1R, FLT3, KIT, PDGFR (PDGFRA, PDGFRB)
FGF受容体ファミリー FGFR1, FGFR2, FGFR3, FGFR4
VEGF受容体sファミリー VEGFR1, VEGFR2, VEGFR3, VEGFR4
HGF受容体ファミリー MET, RON
Trk受容体ファミリー NTRK1, NTRK2, NTRK3
EPH受容体ファミリー EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6, EPHX
LTK受容体ファミリー LTK, ALK
TIE受容体ファミリー TIE, TEK
ROR受容体ファミリー ROR1, ROR2
DDR受容体ファミリー DDR1, DDR2
PTK7受容体ファミリー PTK7
RYK受容体ファミリー RYK
MuSK受容体ファミリー MUSK
ROS受容体ファミリー ROS1
AATYK受容体ファミリー AATYK, AATYK2, AATYK3
AXL受容体ファミリー AXL, MER, TYRO3
RET受容体ファミリー RET
uncatagorised STYK1
Non-受容体 チロシンキナーゼs (EC 2.7.10.2)
ABLファミリー ABL1, ARG
ACKファミリー ACK1, TNK1
CSKファミリー CSK, MATK
FAKファミリー FAK, PYK2
FESファミリー FES, FER
FRKファミリー FRK, BRK, SRMS
JAKファミリー JAK1, JAK2, JAK3, TYK2
SRC-Aファミリー SRC, FGR, FYN, YES1
SRC-Bファミリー BLK, HCK, LCK, LYN
TECファミリー TEC, BMX, BTK, ITK, TXK
SYKファミリー SYK, ZAP70