テンプレート:PBB/1742

PSD-95
PSD-95 第3PDZドメインの立体構造。1BFEによる。
Available structures PDB 1KEF​, 3I4W​, 3K82​, 3ZRT​
Identifiers
Symbols	DLG4; PSD-95; SAP-90; SAP90
External IDs	OMIM: 602887 MGI: 1277959 HomoloGene: 1047 GeneCards: DLG4 Gene
Gene Ontology Molecular function • protein binding • protein C-terminus binding • protein phosphatase binding • PDZ domain binding • beta-1 adrenergic receptor binding • P2Y1 nucleotide receptor binding • protein complex binding • ionotropic glutamate receptor binding • ATP-activated nucleotide receptor activity • ADP-activated nucleotide receptor activity • scaffold protein binding Cellular component • plasma membrane • synaptic vesicle • ionotropic glutamate receptor complex • postsynaptic density • cell junction • endocytic vesicle membrane • cortical cytoskeleton • extrinsic to internal side of plasma membrane • alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex • dendrite cytoplasm • juxtaparanode region of axon • neuron projection terminus • neuron spine • synapse • postsynaptic membrane • excitatory synapse Biological process • adenosine receptor signaling pathway • negative regulation of receptor internalization • protein complex assembly • signal transduction • synaptic transmission • nervous system development • axon guidance • learning • synaptic vesicle maturation • social behavior • protein localization to synapse • locomotory exploration behavior • establishment of protein localization • positive regulation of transcription from RNA polymerase II promoter • regulation of long-term neuronal synaptic plasticity • positive regulation of synaptic transmission • neuromuscular process controlling balance • dendritic spine morphogenesis • vocalization behavior • alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering • receptor localization to synapse • regulation of N-methyl-D-aspartate selective glutamate receptor activity • positive regulation of excitatory postsynaptic membrane potential • regulation of grooming behavior Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1742	13385
Ensembl	ENSG00000132535	ENSMUSG00000020886
UniProt	P78352	Q62108
RefSeq (mRNA)	NM_001128827	NM_001109752
RefSeq (protein)	NP_001122299	NP_001103222
Location (UCSC)	Chr 17: 7.09 – 7.12 Mb	Chr 11: 70.02 – 70.05 Mb
PubMed search	[1]	[2]