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→細胞内物質輸送
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== 細胞内物質輸送 == | == 細胞内物質輸送 == | ||
[[Image:Kinesin1.jpg|thumb|250px|<b>図１ 神経細胞における細胞内物質輸送</b><br />（Hirokawa et al. | [[Image:Kinesin1.jpg|thumb|250px|<b>図１ 神経細胞における細胞内物質輸送</b><br />（Hirokawa et al.<span class=]]<pubmed>21092854</pubmed>より改変" class="fck_mw_frame fck_mw_right" /> | ||
{| | {| cellspacing="1" cellpadding="1" border="1" style="width: 542px; height: 1766px;" | ||
|- | |- | ||
| '''KIFs''' | | '''KIFs''' | ||
| '''結合タンパク質''' | | '''結合タンパク質''' | ||
| '''カーゴまたは機能''' | | '''カーゴまたは機能''' | ||
|- | |- | ||
| KIF1A (C: Unc-104, D: Imac) | | KIF1A (C: Unc-104, D: Imac) | ||
| DENN/MADD (C: Aex-3) | | DENN/MADD (C: Aex-3) | ||
| Synaptic vesicle precursor | | Synaptic vesicle precursor | ||
|- | |- | ||
| KIF1A (C: Unc-104, D: Imac) | | KIF1A (C: Unc-104, D: Imac) | ||
| Liprin-a (C: Syd-2) | | Liprin-a (C: Syd-2) | ||
| Synaptic vesicle precursor | | Synaptic vesicle precursor | ||
|- | |- | ||
| KIF1Ba | | KIF1Ba | ||
| KBP | | KBP | ||
| Mitochondria | | Mitochondria | ||
|- | |- | ||
| KIF1Bb (C: Unc-104, D: Imac) | | KIF1Bb (C: Unc-104, D: Imac) | ||
| DENN/MADD (C: Aex-3) | | DENN/MADD (C: Aex-3) | ||
| Synaptic vesicle precursor | | Synaptic vesicle precursor | ||
|- | |- | ||
| KIF1Bb | | KIF1Bb | ||
| Liprin-a (C: Syd-2) | | Liprin-a (C: Syd-2) | ||
| Synaptic vesicle precursor | | Synaptic vesicle precursor | ||
|- | |- | ||
| KIF1Bb | | KIF1Bb | ||
| Not identified | | Not identified | ||
| mRNA | | mRNA | ||
|- | |- | ||
| KIF1C | | KIF1C | ||
| KBP | | KBP | ||
| Mitochondria? | | Mitochondria? | ||
|- | |- | ||
| KIF2A | | KIF2A | ||
| | | | ||
| Vesicles | | Vesicles | ||
|- | |- | ||
| KIF2A | | KIF2A | ||
| | | | ||
| Microtubule depolymerizer | | Microtubule depolymerizer | ||
|- | |- | ||
| KIF3 | | KIF3 | ||
| Fodrin | | Fodrin | ||
| Plasma membrane precursor | | Plasma membrane precursor | ||
|- | |- | ||
| KIF3 | | KIF3 | ||
| Not identified | | Not identified | ||
| N-cadherin | | N-cadherin | ||
|- | |- | ||
| KIF3 | | KIF3 | ||
| Not identified | | Not identified | ||
| Kv channel | | Kv channel | ||
|- | |- | ||
| KIF4 | | KIF4 | ||
| Not identified | | Not identified | ||
| Membraneous organelle | | Membraneous organelle | ||
|- | |- | ||
| KIF4 | | KIF4 | ||
| PARP-1 | | PARP-1 | ||
| Neuronal survival | | Neuronal survival | ||
|- | |- | ||
| KIF5 (C: Unc-116, D: KHC) | | KIF5 (C: Unc-116, D: KHC) | ||
| Not identified | | Not identified | ||
| mRNA-protein complex | | mRNA-protein complex | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| FMRP | | FMRP | ||
| mRNA-protein complex | | mRNA-protein complex | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| JIP-1 (D: APLIP1) | | JIP-1 (D: APLIP1) | ||
| Vesicles | | Vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| JIP-2 | | JIP-2 | ||
| Vesicles | | Vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| JIP-3 (C: Unc-16, D: Sunday Driver) | | JIP-3 (C: Unc-16, D: Sunday Driver) | ||
| Vesicles, mitochondria? | | Vesicles, mitochondria? | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| APP | | APP | ||
| Vesicles | | Vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Syntabulin | | Syntabulin | ||
| Syntaxin vesicles | | Syntaxin vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Syntabulin | | Syntabulin | ||
| Mitochondria | | Mitochondria | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Milton-Miro complex | | Milton-Miro complex | ||
| Mitochondria | | Mitochondria | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| GRIP | | GRIP | ||
| AMPA receptor vesicles | | AMPA receptor vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Slp-Rab27B | | Slp-Rab27B | ||
| TrkB vesicles | | TrkB vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| HAP1 | | HAP1 | ||
| GABA<sub>A</sub>Rs | | GABA<sub>A</sub>Rs | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Huntingtin | | Huntingtin | ||
| BDNF vesicles | | BDNF vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| LIS1-NUDEL complex | | LIS1-NUDEL complex | ||
| DHC1 | | DHC1 | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| mNUDC | | mNUDC | ||
| Dynactin complex | | Dynactin complex | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| MyosinVa | | MyosinVa | ||
| Vesicles | | Vesicles | ||
|- | |- | ||
| KIF5 | | KIF5 | ||
| Hsc70 | | Hsc70 | ||
| Cargos of slow transport | | Cargos of slow transport | ||
|- | |- | ||
| KIF13B (GAKIN) | | KIF13B (GAKIN) | ||
| MAGUKs (D: discs large) | | MAGUKs (D: discs large) | ||
| MAGUK vesicles | | MAGUK vesicles | ||
|- | |- | ||
| KIF13B | | KIF13B | ||
| PIP3BP | | PIP3BP | ||
| PIP3 vesicles | | PIP3 vesicles | ||
|- | |- | ||
| KIF17 | | KIF17 | ||
| Mint | | Mint | ||
| NR2B vesicles | | NR2B vesicles | ||
|- | |- | ||
| KIF26A | | KIF26A | ||
| Grb2 | | Grb2 | ||
| Inhibition of GDNF-Ret signaling | | Inhibition of GDNF-Ret signaling | ||
|- | |- | ||
| KIFC2 | | KIFC2 | ||
| Not identified | | Not identified | ||
| Multivesicular-body-like organelle | | Multivesicular-body-like organelle | ||
|} | |} | ||
<br> | |||
細胞はその形態形成、及び機能発現に必要なタンパク質を合成した後、多種類の膜小器官あるいはタンパク質複合体として必要とされる部位に適切に送り分けており、この細胞内物質輸送の機構は神経細胞や極性のある上皮細胞のみでなく、あらゆる細胞で細胞機能の重要な基盤となっている。 細胞内物質輸送を担うモータータンパク質には大きく分けて、キネシン、ダイニン、ミオシンの3つがある（図１）<ref name="ref2"><pubmed>21092854</pubmed></ref>。 | 細胞はその形態形成、及び機能発現に必要なタンパク質を合成した後、多種類の膜小器官あるいはタンパク質複合体として必要とされる部位に適切に送り分けており、この細胞内物質輸送の機構は神経細胞や極性のある上皮細胞のみでなく、あらゆる細胞で細胞機能の重要な基盤となっている。 細胞内物質輸送を担うモータータンパク質には大きく分けて、キネシン、ダイニン、ミオシンの3つがある（図１）<ref name="ref2"><pubmed>21092854</pubmed></ref>。 | ||