テンプレート:PBB/5649

Reelin
Crystallographic structure of the third reelin repeat domain based on PDB 2ddu.
Available structures PDB 2ddu​, 2e26​
Identifiers
Symbols	RELN; LIS2; PRO1598; RL
External IDs	OMIM: 600514 MGI: 103022 HomoloGene: 3699 GeneCards: RELN Gene
EC number	3.4.21.-
Gene Ontology Molecular function • protein serine/threonine/tyrosine kinase activity • serine-type peptidase activity • metal ion binding • lipoprotein particle receptor binding • very-low-density lipoprotein particle receptor binding Cellular component • proteinaceous extracellular matrix • extracellular space • cytoplasm • dendrite Biological process • cell morphogenesis involved in differentiation • neuron migration • proteolysis • cell adhesion • axon guidance • central nervous system development • brain development • long-term memory • associative learning • glial cell differentiation • positive regulation of neuron projection development • positive regulation of phosphatidylinositol 3-kinase cascade • dendrite development • peptidyl-tyrosine phosphorylation • spinal cord patterning • ventral spinal cord development • hippocampus development • cerebral cortex tangential migration • positive regulation of TOR signaling cascade • positive regulation of CREB transcription factor activity • reelin-mediated signaling pathway • positive regulation of protein kinase activity • response to pain • positive regulation of peptidyl-tyrosine phosphorylation • regulation of behavior • regulation of synaptic transmission • positive regulation of small GTPase mediated signal transduction • positive regulation of synaptic transmission, glutamatergic • positive regulation of dendritic spine morphogenesis • positive regulation of protein tyrosine kinase activity • positive regulation of synapse maturation • N-methyl-D-aspartate receptor clustering • postsynaptic density protein 95 clustering • receptor localization to synapse • positive regulation of long-term synaptic potentiation • regulation of N-methyl-D-aspartate selective glutamate receptor activity • positive regulation of excitatory postsynaptic membrane potential • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5649	19699
Ensembl	ENSG00000189056	ENSMUSG00000042453
UniProt	P78509	Q60841
RefSeq (mRNA)	NM_005045	NM_011261
RefSeq (protein)	NP_005036	NP_035391
Location (UCSC)	Chr 7: 103.11 – 103.63 Mb	Chr 5: 21.88 – 22.34 Mb
PubMed search	[1]	[2]

References

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