「テスト」の版間の差分

提供：脳科学辞典
ナビゲーションに移動 検索に移動
細編集の要約なし
細編集の要約なし
(3人の利用者による、間の142版が非表示)
1行目: 1行目:
|+ 表1 主なS-パルミトイル化タンパク質<br>
[[File:Nozaki dysphasia movie1.mp4|500px|thumb|'''動画1''']]
{| style="width: 587px; height: 457px" border="1" cellspacing="1" cellpadding="1"
[[File:Nozaki dysphasia movie2.mp4|500px|thumb|'''動画2''']]
|-
[[File:Nozaki dysphasia movie3.mp4|500px|thumb|'''動画3''']]
| ファミリー<br>
[[File:Nozaki dysphasia movie4.mp4|500px|thumb|'''動画4''']]
| 主な例<br>
|-
| '''Signalling protein'''<br>　Small GTPase<br>　Gα subunit<br>　Src family<br>　Others<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
|-
|  
'''Transmembrane'''<br>　Ion channel<br>　GPCR<br>　Cell adhesion molecule<br>　Transporter<br>　Matrix metalloproteinase<br>　Myelin associated<br>　Secretase<br>　Cell death signalling<br>
 
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
|-
| '''Adaptor, Scaffold'''<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
|-
| '''Viral protein'''<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
|-
| '''N-palmitoylated protein'''<br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
|}
 
<br>
 
<br>
{| border="1" cellspacing="1" cellpadding="1"
|+表２ パルミチルトランスフェラーゼ
 
<br>
 
 
 
|-
! scope="col" | 酵素
! scope="col" | 別名
! scope="col" | 主な基質
! scope="col" | 局在（過剰発現系）
! scope="col" | 関連疾患
|-
| DHHC1
| ZDHHC1
| <br>
| ER
| <br>
|-
| DHHC2
| ZDHHC2
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>
| ER/ゴルジ体<br>
| 癌<br>
|-
| DHHC3<br>
|
ZDHHC3
 
GODZ<br>
 
| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>
| ゴルジ体<br>
| <br>
|-
| DHHC4<br>
| ZDHHC4<br>
| BACE1<br>
| ゴルジ体<br>
| <br>
|-
| DHHC5<br>
| ZDHHC5<br>
| STREX<br>
| <br>
| <br>
|-
| DHHC6<br>
| ZDHHC6<br>
| <br>
| <br>
| <br>
|-
| DHHC7<br>
| ZDHHC7<br>
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>
| ゴルジ体<br>
| <br>
|-
| DHHC8<br>
| ZDHHC8<br>
| PSD95, SNAP25, eNOS, paralemmin-1<br>
| ゴルジ体<br>
| 統合失調症<br>
|-
| DHHC9'''<br>'''
| ZDHHC9<br>
| H-RAS, N-Ras<br>
| ER/ゴルジ体<br>
| 癌、X連鎖神経遅滞<br>
|-
| DHHC10<br>
| ZDHHC11<br>
| <br>
| ER<br>
| <br>
|-
| DHHC11<br>
| ZDHHC23<br>NIDD<br>
| <br>
| ER<br>
| 癌<br>
|-
| DHHC12<br>
| ZDHHC12<br>
| ABC transporter A1<br>
| ER/ゴルジ体<br>
| <br>
|-
| DHHC13<br>
| ZDHHC24<br>
| huntingtin<br>
| ER<br>
| <br>
|-
| DHHC14<br>
| ZDHHC14<br>
| <br>
| ER<br>
| <br>
|-
| DHHC15<br>
| ZDHHC15<br>
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>
| ゴルジ体<br>
| X連鎖神経遅滞<br>
|-
| DHHC16<br>
| ZDHHC16<br>
| <br>
| ER<br>
| <br>
|-
| DHHC17<br>
|
ZDHHC17
 
HIP14<br>
 
| SNAP25, huntingtin, <br>
| ゴルジ体<br>
| ハンチントン病、癌<br>
|-
| DHHC18<br>
| ZDHHC18<br>
| <br>
| ゴルジ体<br>
| <br>
|-
| DHHC19<br>
| ZDHHC19<br>
| R-Ras<br>
| ER<br>
| <br>
|-
| DHHC20<br>
| ZDHHC20<br>
| BACE1, ABC transporter 1<br>
| 細胞膜<br>
| <br>
|-
| DHHC21<br>
| ZDHHC21<br>
| eNOS, Lck, Fyn, ABC transporter 1<br>
| 細胞膜<br>
| <br>
|-
| DHHC22<br>
| ZDHHC13<br>
| <br>
| ER/ゴルジ体<br>
| <br>
|-
| DHHC23<br>
| ZDHHC25<br>
| <br>
| <br>
| <br>
|-
| <br>
| ZDHHC22<br>
| <br>
| <br>
| <br>
|}
 
&nbsp; <br>
 
 
 
{| style="width: 618px; height: 1074px" border="1" cellspacing="1" cellpadding="1" width="618"
|-
| Category
| Family
| N-Myristoylated protein
|-
| Kinase/Phosphatase
| Src family kinase
| Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
|-
|
| Abl tyrosine kinase
| c-Abl, Arg
|-
| <br>
| Ser/Thr kinase
| cAMP-dependent protein kinase, AKAP18
|-
| <br>
| phosphatase
| Calcineurin B
|-
| GTP-binding protein
| Gα
| Gα i1, Gαo, Gαt, Gαx
|-
|
| ADP-ribosylation factor
| Arf-1, Arf-3, Arf-5, Arf-6
|-
| Ca2+ binding /<br>EF hand protein
|
| Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,<br>Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
|-
| Membrane/cytoskeletal-<br>bound protein
|
| MARCKS, Annexin　XIII, <br>Rapsyn, Pallidin, Hisactophilin 2
|-
| Viral protein
| Gag protein
| HIV-1, Moloney murine, sarcoma virus, Friend murine,<br>leukemia virus
|-
|
| Others
| HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,<br>Herpes simplex virus
|-
| Others
|
| eNOS
|-
| Caspase-cleavage <br>post-translational<br>N-myristoylated protein
|
| β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,<br>MST3, PKC,
|}

2020年12月1日 (火) 21:21時点における版

動画1
動画2
動画3
動画4
「https://bsd.neuroinf.jp/w/index.php?title=テスト&oldid=45213」から取得