「テンプレート:Infobox drug/doc」の版間の差分

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{{Documentation subpage}}

{{Template shortcut|Drugbox}}

{{Tracks Wikidata|P628|P2566|cat=E number from Wikidata|section=Input from Wikidata}}

{{Lua|Module:Infobox|Module:InfoboxImage|Module:Wikidata|Module:String|Module:TemplatePar|Module:ParameterCount}}

'''{{tl|Infobox drug}}''' or {{tlf|Drugbox}} is the infobox for drugs, both medical and recreational. It can be used for single chemicals (most common), and for [[#Combination products]], [[#Monoclonal antibody drugs]] and [[#Vaccines]].

== Type of drug ==

{{anchor|1=Single chemical}}

Drugs that are a simple chemical compound (about 90% of the drug articles are). Short parameter list:

{{Infobox drug

| drug_name        =  

| INN              =  

| image            =  

| alt              =  

| caption          =  

| Drugs.com        =  

| MedlinePlus      =  

| pregnancy_AU_comment =  

| pregnancy_category=  

| routes_of_administration =  

| ATC_prefix        = <!-- 'none' if uncategorised -->

| ATC_suffix        =  

<!-- Pharmacokinetic data -->

| bioavailability  =  

| excretion        =  

<!-- Identifiers -->

| CAS_number        =  

| PubChem          =  

| DrugBank          =  

<!-- Chemical and physical data -->

| chemical_formula  =  

| molecular_weight  =  

}}

'''Full single-drug template''' with extended fields:

{{Infobox drug

| drug_name        =  

| INN              =  

| image            =  

| width            =  

| alt              =  

| image2            =  

| width2            =  

| alt2              =  

| imageL            =  

| widthL            =  

| altL              =  

| imageR            =  

| widthR            =  

| altR              =  

<!-- Clinical data -->

| pronounce        =  

| DailyMedID        = <!-- DailyMed may use generic or brand name (generic name preferred) -->

| licence_US        = <!-- FDA may use generic or brand name (generic name preferred) -->

| pregnancy_AU_comment =  

| pregnancy_category=  

| dependency_liability =  

| addiction_liability =  

| ATC_supplemental  =  

<!-- Legal status -->

| legal_AU_comment  =  

| legal_BR_comment  =  

| legal_CA_comment  =  

| legal_DE_comment  =  

| legal_NZ_comment  =  

| legal_UK_comment  =  

| legal_US_comment  =  

| legal_UN_comment  =  

<!-- Pharmacokinetic data -->

| bioavailability  =  

| IUPAC_name        =  

| chemical_formula  =  

| molecular_weight  =  

| SMILES            =  

| specific_rotation =  

}}

{{anchor|1=Combination of drugs}}

Example for [[Seretide]]:

| drug_name  = Seretide

| type      = combo

| component1 = Fluticasone

| class1    = [[Glucocorticoid]]

| class2    = [[Beta2-adrenergic receptor agonist|Long-acting beta2 agonist]]

}}

| drug_name  = Seretide

| type      = combo

| component1 = Fluticasone

| class1    = [[Glucocorticoid]]

| component2 = Salmeterol

| class2    = [[Beta2-adrenergic receptor agonist|Long-acting beta2 agonist]]

Generally combination articles will not need to display the molecular images of its constituents (the relevant specific articles would have the images). It disables all Chemical & Pharmacology parameters (which describe properties of single drug items). These redundant disabled parameters are best not included in the template calling, so use the following abridged forms of the template:

'''Shortened combination product form:'''

{{Infobox drug

| type              = combo

| component1        = <!-- Drugname, automatically linked -->

| class1            = <!-- Group, manual link using [[..|..]] -->

| class2            = <!-- Group, manual link using [[..|..]] -->

<!-- Clinical data -->

| tradename        =  

| Drugs.com        =  

| MedlinePlus      =  

| pregnancy_category=  

| routes_of_administration =  

| ATCvet            =  

| ATC_prefix        = <!-- 'none' if uncategorised -->

| ATC_suffix        =  

}}

{{Infobox drug

| drug_name        =  

| type              = combo

| component1        = <!-- Drugname, automatically linked -->

| class1            = <!-- Group, manual link using [[..|..]] -->

| component4        = <!-- Drugname, automatically linked -->

| class4            = <!-- Group, manual link using [[..|..]] -->

<!-- Clinical data -->

| tradename        =  

| Drugs.com        =  

| licence_CA        = <!-- Health Canada may use generic or brand name (generic name preferred) -->

| licence_EU        = <!-- EMA uses INN (or special INN_EMA) -->

| licence_US        = <!-- FDA may use generic or brand name (generic name preferred) -->

| pregnancy_category=  

| dependency_liability =  

| addiction_liability =  

| routes_of_administration =  

| ATCvet            =  

| ATC_prefix        = <!-- 'none' if uncategorised -->

| ATC_suffix        =  

| ATC_supplemental  =  

| UNII              =  

| KEGG              =  

| synonyms          =  

}}

{{anchor|1=Monoclonal antibody drugs}}

* {{para|type|mab}}

This form the box uses parameters:

| type      = mab

For example [[Catumaxomab]]:

| drug_name  = Catumaxomab

| type      = mab

| mab_type  = 3funct

| source    = axo

| target    = [[EpCAM]], [[CD3 (immunology)|CD3]]

}}

| type      = mab

| mab_type  = 3funct

| source    = axo

| target    = [[EpCAM]], [[CD3 (immunology)|CD3]]

'''mab_type''' defines one of the following types of antibody or antibody fragment:

'''Shortened Monoclonal antibody form:'''

{{Infobox drug

| type              = mab

| image            =  

| alt              =  

| mab_type          = <!-- mab, Fab, F(ab')2, Fab', scFv, di-scFv, 3funct, clFab, BiTE -->

| source            = <!-- a, e, i, o, u, xi/a, zu/a, xizu/a, axo, ... -->

| target            = <!-- antigen, not the code number of the monoclonal antibody! -->

<!-- Clinical data -->

| tradename        =  

| Drugs.com        =  

| MedlinePlus      =  

| routes_of_administration =  

<!-- Pharmacokinetic data -->

| bioavailability  =  

| protein_bound    =  

| metabolism        =  

| onset            =  

| elimination_half-life =  

<!-- Identifiers -->

| CAS_number        =  

| PubChem          =  

| DrugBank          =  

}}

* {{para|type|vaccine}}

This allows the alternative parameters of the '''vaccine_type''' and '''target''' to be specified:

! vaccine_type value !! Output

|-

|-

|-

|-

| toxoid || [[Toxoid]]

|-

|-

|-

|-

|-

|-

| ''any text'' || ''any text'' (shows unedited)

'''Shortened Vaccine form:'''

{{Infobox drug

| drug_name        =  

| type              = vaccine

| image            =  

| alt              =  

| vaccine_type      = <!-- killed/attenuated/live/toxoid/protein subunit/subunit/conjugate/recombinant/DNA -->

<!-- Clinical data -->

| tradename        =  

| Drugs.com        =  

| MedlinePlus      =  

| routes_of_administration =  

| ATCvet            =  

| ATC_prefix        = <!-- 'none' if uncategorised -->

| ATC_suffix        =  

| PubChem          =  

| DrugBank          =  

}}

'''Full Vaccine template''' with extended fields:

{{Infobox drug

| type              = vaccine

| image            =  

| alt              =  

| width            =  

| image2            =  

| alt2              =  

| width2            =  

| target            = <!-- the antigen/bacteria/toxin/virus to protect against -->

| vaccine_type      = <!-- killed/attenuated/live/toxoid/protein subunit/subunit/conjugate/recombinant/DNA -->

<!-- Clinical data -->

| tradename        =  

| Drugs.com        =  

| licence_CA        = <!-- Health Canada may use generic or brand name (generic name preferred) -->

| licence_EU        = <!-- EMA uses INN (or special INN_EMA) -->

| licence_US        = <!-- FDA may use generic or brand name (generic name preferred) -->

| pregnancy_category=  

| routes_of_administration =  

<!-- Identifiers -->

| CAS_number        =  

| CAS_supplemental  =  

| PubChem          =  

| PubChemSubstance  =  

| ChEBI            =  

| ChEMBL            =  

}}

== Parameters ==

=== Infobox title and INN ===

{{infobox drug|drug_name=Aspirin|image=Blank file.xcf|width=5px}}

When, for some reason, the title is ''not'' the INN, the correct INN can be added as a subtitle using {{para|INN}}

{{infobox drug|drug_name=Heroin| INN=Diamorphine|image=Blank file.xcf|width=5px}}

  | drug_name = Heroin

  | INN = Diamorphine

&nbsp;

When the drug has no INN at all, setting {{para|INN|none}} will suppress the tooltip text mentioning INN.

=== Images ===

{{Infobox drug

| drug_name = demo: image

| caption          = structure

| alt              = Molecule of aspirin

| width            = 125

}}

| caption          = structure

| alt              = Molecule of aspirin

| width            = 125

{{clear}}

A second image can be added using '''image2''':

| image2            =  

| caption2          =  

| alt2              =  

| width2            =  

Also a side-by-side pair of images can be added (with single caption):

See also [[#Other chemical data|{{para|SMILES}}]] input for the 3D model by [[Jmol]] (an external link).

=== Clinical data ===

* '''tradename''' – comma separated list of trade names by the originator (no generics, not more than three names)

==== Pregnancy category ====

:''See also [[Template:Infobox drug/pregnancy category|pregnancy category, documentation]] for extensive documentation''

{{Infobox drug

| drug_name=Demo pregnancy

   | pregnancy_AU = B1

   | pregnancy_category = Used in pregnancy against [[Pregnancy-induced hypertension|PIH]]

}}

   | pregnancy_AU = B1

   | pregnancy_category = Used in pregnancy against [[Pregnancy-induced hypertension|PIH]]

==== Dependence liability ====

Optional parameters '''Dependence liability''' and '''Addiction_liability''' allow opioids or benzodiazepines to be flagged with the risk of becoming dependent/addicted upon them, although in many cases this may be somewhat subjective. Drugs should be rated as ''Low'', ''Medium'', ''High'' or ''Extremely high'':

| dependency_liability = High

| addiction_liability = High

==== Licensing information ====

The FDA "Label Information" and the EMA "Product Information", where available, are very detailed. There is material aimed at the professional and also plain-English consumer information. These are excellent reliable source for article information but also contains much that makes it a worthwhile "External link" since there is no way one can include all the info. Both sites work when using the brand name of the drug but the FDA site also allows searches with the generic name (active ingredient), which lists generic variants where they are licensed. Health Canada's site operates similarly to the FDA's site, with Canada-specific drug monographs and other information. The DailyMed site is a more user-friendly repository of primarily labeling information. For all sites, the use of the generic name of the drug is preferred whenever possible as this will list all brand and generic forms of the drug.

| licence_EU = <!-- Any input here (like '=yes'), will give link by INN -->

| DailyMedID = <!-- DailyMed may use generic or brand name (generic name preferred) -->

| licence_US = <!-- or |license_US=; FDA may use generic or brand name (generic name preferred) -->

:{{para|licence_EU|yes}} will create a link to the EMA site, using the INN (i.e., INN, drug_name or article title). When the EMA used INN is different, enter its INN in {{para|INN_EMA}}.

Lists of products and the parameter term to use may be easily searched for:

* Licence EU (EMA): ''any'' input in {{para|licence_EU}} will give a link to the EMA page for the active substance (INN).

* Drugs@FDA [http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name Search by Drug Name or Active Ingredient]

==== Drug class ====

| class = any text

The [[drug class]] designates the family that this drug belongs to. Typically the chemical class (e.g., [[benzodiazepine]]), mechanism of action (e.g., [[beta blocker]]), mode of action (e.g., [[diuretic]]), and/or therapeutic class (e.g., [[analgesic]]).  Hence this field may contain more than one drug class if appropriate (each preferably [[WP:WIKILINK|wiki linked]]).

{{see|Wikipedia:WikiProject Pharmacology/Style guide#Use ATC codes}}

Where the drug is not included in ATC coding system (as opposed to its value just not been entered into the template) then set '''ATC_prefix''' to 'none', and the article is automatically added to [[:Category:Drugs not assigned an ATC code]]:

| ATC_prefix        = none

Additional ATC(vet) may be included with the optional {{para|'''ATC_supplemental'''}} parameter as a comma-separated list. ATC templates may be used to have these additional codes link to the relevant databases:

| ATC_supplemental ={{ATC|M02|AA15}}, {{ATCvet|S01|BC03}}

Adds the following linked codes:

:For ATC – {{ATC|M02|AA15}}, {{ATCvet|S01|BC03}}

Veterinary drugs are placed in a slightly different classification system, [[Anatomical Therapeutic Chemical Classification System#ATCvet|ATCvet]]. The code may be specified as ATCvet by setting the parameter '''ATCvet''' to 'yes'. Do not include the leading 'Q' in '''ATC_prefix''':

| ATCvet            = yes

| ATC_prefix        = N05

| ATC_suffix        = AX90

When the ATCvet code happens to be the same as the ATC for a mainly human drug, it is usually a better idea to just provide the ATC in the infobox.

| legal_BR    = A1

| legal_BR_comment = any text

| legal_DE    =  

| legal_UK    = gsl

| legal_US    = Schedule II

| legal_US_comment = and OTC in Oregon

| legal_NZ    =  

| legal_status = Not marketed in Asia

}}

| legal_AU    = S2

| legal_AU_comment = any text

| legal_US    = Schedule II

| legal_US_comment = and OTC in Oregon

| legal_NZ    =  

| legal_status = Not marketed in Asia

Note: if a drug is restricted everywhere to prescription-only, please set '''legal_status = Rx-only''' rather than similarly define for each and every country. {{para|legal_status|Rx-only}} is specifically recognised and shows as {{Infobox drug/legal status|legal_status=Rx-only}}

|-

! Input !! Meaning

|C3|| Class C3: Immunosuppressive Drugs

|-

|-

|C5|| Class C5: Anabolic steroids

|E|| Class E: Controlled plants

|-

|-

! legal_CA !! Canada

| Schedule V

|-

|-

|-

|}

=== Pharmacokinetic data ===

Use wikilinks for values that the general reader might not understand (e. g. [[hepatic]], [[CYP3A4]], [[intraperitoneal]]).

   | bioavailability  =  

   | protein_bound    =  

   | metabolism        =  

   | onset            =  

   | elimination_half-life =  

   | duration_of_action=  

   | excretion        =  

=== Names and identifiers ===

{{para|CAS_number}}

Additional CAS codes may be included with optional {{para|CAS_supplement}} parameters in a comma-separated lists. CAS templates may be used to have these additional codes link to the relevant databases:

| CAS_supplemental ={{CAS|427-51-0}} (acetate)

Adds the following linked codes:

:For CAS – {{CAS|427-51-0}} (acetate)

When available, the [[PubChem]] ''compound'' identifier (CID) should be used because it is unique for each chemical compound:

| PubChem        = 4091  <!-- Metformin -->

Make sure you choose the right CID: Often PubChem compound entries differ only very slightly, for example by an additional hydratation water or by a carbon atom with unspecified stereochemistry.

If no CID is available, which is usually the case when there is no structural information on PubChem, you may use one of the ''substance'' identifiers (SIDs):

| PubChemSubstance    = 10099  <!-- Etanercept -->

==== CompTox (EPA database) ====

{{anchor|1=Second identifier}}

{{collapse top|title=Using second identifiers|bg=#ddd}}

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|-

|}

All identifiers can have a second, index-2 identifier, representing a second chemical substance. For example, {{para|CAS_number|536-71-0}}, {{para|CAS_number2|908-54-3}}.

{{infobox drug

| drug_name=Demo indexes<br/>([[Diminazen]])

| index_label=  

| index2_label=aceturate

| UNII = Y5G36EEA5Z

| UNII2 = JI8SAD85NO

}}</div>

{{infobox drug

| drug_name=Demo indexes<br/>([[Diminazen]])

| index_label=  

| index2_label=aceturate

| UNII = Y5G36EEA5Z

| UNII2 = JI8SAD85NO

}}

* When index 2 is used, consider adding {{para|index_label}}  and {{para|index2_label}} prefixes, to appear before every identifier.

* These index prefixes can be explained using {{para|index_comment}}, {{para|index2_comment}} which will show in top.

==== Chemical formula ====

Entering the chemical formula per element:

| C= | H= | Ag= | Al= | As= | Au= | B= | Bi= | Br= | Ca= | Cl= | Co= | F= | Fe= | Gd= | I=

| K= | Li= | Mg= | Mn= | N= | Na= | O= | P= | Pt= | S= | Sb= | Se= | Sr= | Tc= | Zn=  

<!-- all 118 symbols -->

| charge=

E.g.

| C=2 | H=6 | O=1 | charge=2-

gives

:Formula {{Chembox Elements/molecular formula| C=2 | H=6 | O=1 | charge=2-}}

You can provide the chemical formula as fixed

''todo: example''

Additional chemical data fields are [[Simplified molecular-input line-entry system|SMILES]] and standard [[International Chemical Identifier|InChI]] (optionally oncluding a comment and standard InChIKey).

;The Jmol 3D model

When {{para|SMILES}} has input, the template automatically adds an external link to the Jmol 3D molecule model.

==== Physical data ====

This is entirely optional data, and for most drugs is '''not helpful''' to the wider readership. Only include if information of particular interest for the drug as to its chemical properties (e.g. in its manufacture or as an important chemical in its own right, e.g. [[Aspirin]]).

| density          =  

| melting_point    =  

| boiling_point    =  

| sol_units        =  

| specific_rotation =  

The template will add the following to the numeric values provided:

*'''Density''' – added 'g/cm³'

Hence:

| solubility = 100

| sol_units  = &amp;nbsp;g/L ({{Convert|212|F|C}})

gives:

:Solubility  100&nbsp;g/L (212&nbsp;°F (100&nbsp;°C))

Hence:

| melting_point = 100

| melting_high  = 104

gives:

:Melting point  100–104&nbsp;°C (212–219&nbsp;°F)

Hence:

| boiling_point = 100

| boiling_notes = (sublimes)

gives:

:Boiling point  100&nbsp;°C (212&nbsp;°F) (sublimes)

When this section has input, sections Clinical data and Legal data should be empty.

<!-- Physiological data -->

| source_tissues =  

| biosynthesis  =  

| metabolism    = <!-- same parameter as in pharmacokinetic data -->

Example:

{{Infobox drug

| metabolism    = [[oxytocinase]]

}}

| drug_name      = [[Oxytocin]]

<!-- Physiological data -->

| biosynthesis  = [[magnolysin]]

| metabolism    = [[oxytocinase]]

* Categorised: {{Category link with count|Drugs that are a physiological drug}}

===Gene therapy===

| gt_vector            =  

| gt_nucleic_acid_type =  

| gt_editing_method    =  

| gt_delivery_method  =  

Example:

| gt_delivery_method  = [not applicable here]

}}

{{Infobox drug

| drug_name            = [[Voretigene neparvovec]]

| gt_delivery_method  = [not applicable here]

}}

* Categorised: {{Category link with count|Drugs that are a gene therapy}}

===Input from Wikidata===

See also {{cl|Chemical compounds and Wikidata}}.

==Miscellaneous==

=== Verification by CheMoBot (parameters: ..._Ref) ===

{{para|verifiedrevid}} and {{para|CAS_number_Ref|<nowiki>{{cascite|correct}}</nowiki>}}. See also {{tl|cascite}} documentation.

The default spelling in the infobox is en-US: "LicenSe". Setting {{para|engvar|2=en-AU, en-CA, en-EI, en-NZ, en-UK}} spells "LicenCe". Again, this should follow the article's overall language.

=== Section overview by {{para|type}} options ===

A {{para|type}} can use specific headers.

| type=mab

| type=vaccine

| type=combo

| type=

:Types are listed in {{cl|Drugs by type}}

Dependent sections:

{{Infobox drug/doc/type-conditional sections|state=collapsed}}

== TemplateData ==

{{TemplateData header|noheader=1}}

<templatedata>

{

"description": "This infobox provides information over-the-counter and prescription-only drugs. It can be used for single drugs, combination products, monoclonal antibodies and vaccines.",

"params": {

"drug_name": {

"label": "Drug name",

"suggested": true

},

"image": {

"label": "Image",

"type": "wiki-file-name",

},

"width": {

"label": "Image width",

},

"alt": {

"description": "Describe the appearance of the image, for people who cannot see the image",

"example": "Two scored pills, one pink with a large numeral 1 stamped in the surface, and the other tan and marked with a large numeral 3",

"suggested": true

},

"image2": {},

"width2": {},

"alt2": {},