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| 567行目: |
567行目: |
| | [[14-3-3タンパク質]] | | | [[14-3-3タンパク質]] |
| | 14-3-3 protein、14-3-3 proteins | | | 14-3-3 protein、14-3-3 proteins |
| |}
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|
| |
| ==追加候補用語==
| |
| {| class="wikitable"
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| |+ 神経変性疾患に関連する新規項目候補
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| ! 分類
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| ! 新規項目候補
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| ! 同義語・略語・英語名
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| |-
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| ! rowspan="15" | 疾患・疾患群
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| | [[神経変性疾患]]
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| | neurodegenerative disease、neurodegenerative disorders
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| |-
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| | [[パーキンソン病]]
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| | Parkinson病、Parkinson disease、Parkinson's disease、PD
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| |-
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| | [[パーキンソニズム]]
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| | parkinsonism、パーキンソン症候
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| |-
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| | [[パーキンソン症候群]]
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| | Parkinsonian syndrome
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| |-
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| | [[前頭側頭葉変性症]]
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| | frontotemporal lobar degeneration、FTLD
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| |-
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| | [[大脳皮質基底核変性症]]
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| | corticobasal degeneration、CBD
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| |-
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| | [[大脳皮質基底核症候群]]
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| | corticobasal syndrome、CBS
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| |-
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| | [[プリオン病]]
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| | prion disease、prion diseases
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| |-
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| | [[運動ニューロン病]]
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| | motor neuron disease、motor neuron diseases、MND
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| |-
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| | [[球脊髄性筋萎縮症]]
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| | spinal and bulbar muscular atrophy、SBMA、Kennedy病、Kennedy disease
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| |-
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| | [[遺伝性痙性対麻痺]]
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| | hereditary spastic paraplegia、hereditary spastic paraparesis、HSP
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| |-
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| | [[神経核内封入体病]]
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| | neuronal intranuclear inclusion disease、NIID、neuronal intranuclear inclusion body disease
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| |-
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| | [[辺縁系優位型加齢性TDP-43脳症]]
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| | limbic-predominant age-related TDP-43 encephalopathy、LATE
| |
| |-
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| | [[原発性加齢関連タウオパチー]]
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| | primary age-related tauopathy、PART
| |
| |-
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| | [[慢性外傷性脳症]]
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| | chronic traumatic encephalopathy、CTE
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|
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| |-
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| ! rowspan="11" | アルツハイマー病関連分子
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| | [[アポリポタンパク質E]]
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| | apolipoprotein E、ApoE、APOE
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| |-
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| | [[アミロイド前駆体タンパク質]]
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| | amyloid precursor protein、amyloid-β precursor protein、APP、アミロイド前駆タンパク質
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| |-
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| | [[TREM2]]
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| | triggering receptor expressed on myeloid cells 2、triggering receptor expressed on myeloid cells-2
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| |-
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| | [[プレセニリン1]]
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| | presenilin 1、presenilin-1、PSEN1、PS1
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| |-
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| | [[プレセニリン2]]
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| | presenilin 2、presenilin-2、PSEN2、PS2
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| |-
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| | [[BACE1]]
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| | beta-site APP-cleaving enzyme 1、β-site APP-cleaving enzyme 1、beta-secretase 1、β-secretase 1、βセクレターゼ1
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| |-
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| | [[γセクレターゼ]]
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| | gamma-secretase、γ-secretase
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| |-
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| | [[CD33]]
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| | CD33 molecule、Siglec-3、SIGLEC3
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| |-
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| | [[クラステリン]]
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| | clusterin、CLU、apolipoprotein J、ApoJ
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| |-
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| | [[PICALM]]
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| | phosphatidylinositol-binding clathrin assembly protein
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| |-
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| | [[BIN1]]
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| | bridging integrator 1
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|
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| |-
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| ! rowspan="8" | パーキンソン病・シヌクレイノパチー関連
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| | [[PINK1]]
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| | PTEN-induced kinase 1、PTEN-induced putative kinase 1、PARK6
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| |-
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| | [[LRRK2]]
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| | leucine-rich repeat kinase 2、PARK8、dardarin
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| |-
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| | [[GBA1]]
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| | glucosylceramidase beta 1、glucocerebrosidase、β-glucocerebrosidase、GBA
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| |-
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| | [[DJ-1]]
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| | PARK7、Parkinson disease protein 7
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| |-
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| | [[VPS35]]
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| | vacuolar protein sorting 35、vacuolar protein sorting-associated protein 35
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| |-
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| | [[レビー小体]]
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| | Lewy body、Lewy bodies
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| |-
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| | [[シヌクレイノパチー]]
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| | synucleinopathy、synucleinopathies
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| |-
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| | [[マイトファジー]]
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| | mitophagy、mitochondrial autophagy
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|
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| |-
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| ! rowspan="12" | ALS・FTLD関連分子
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| | [[プログラニュリン]]
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| | progranulin、GRN、PGRN
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| |-
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| | [[TMEM106B]]
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| | transmembrane protein 106B
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| |-
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| | [[TBK1]]
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| | TANK-binding kinase 1
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| |-
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| | [[オプチニューリン]]
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| | optineurin、OPTN
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| |-
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| | [[セクエストソーム1]]
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| | sequestosome 1、SQSTM1、p62
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| |-
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| | [[ユビキリン2]]
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| | ubiquilin 2、UBQLN2
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| |-
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| | [[VCP]]
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| | valosin-containing protein、p97
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| |-
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| | [[アタキシン2]]
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| | ataxin-2、ATXN2
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| |-
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| | [[hnRNPA1]]
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| | heterogeneous nuclear ribonucleoprotein A1、HNRNPA1
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| |-
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| | [[マトリン3]]
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| | matrin 3、MATR3
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| |-
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| | [[プロフィリン1]]
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| | profilin 1、PFN1
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| |-
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| | [[CHCHD10]]
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| | coiled-coil-helix-coiled-coil-helix domain-containing protein 10
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|
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| |-
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| ! rowspan="9" | ポリグルタミン病・リピート伸長病・SMA関連
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| | [[ハンチンチン]]
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| | huntingtin、HTT、huntingtin protein
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| |-
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| | [[ポリグルタミン病]]
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| | polyglutamine disease、polyglutamine diseases、polyQ disease、polyQ diseases
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| |-
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| | [[リピート伸長病]]
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| | repeat expansion disease、repeat expansion disorders
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| |-
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| | [[RAN翻訳]]
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| | repeat-associated non-AUG translation、RAN translation
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| |-
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| | [[ジペプチドリピートタンパク質]]
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| | dipeptide repeat protein、DPR protein、DPR
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| |-
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| | [[アタキシン1]]
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| | ataxin-1、ATXN1
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| |-
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| | [[アタキシン3]]
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| | ataxin-3、ATXN3
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| |-
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| | [[SMN1]]
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| | survival motor neuron 1
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| |-
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| | [[SMN2]]
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| | survival motor neuron 2
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|
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| |-
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| ! rowspan="15" | 神経変性疾患に共通する病理・病態
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| | [[タウオパチー]]
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| | tauopathy、tauopathies
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| |-
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| | [[TDP-43プロテイノパチー]]
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| | TDP-43 proteinopathy、TDP-43 proteinopathies
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| |-
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| | [[プロテイノパチー]]
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| | proteinopathy、proteinopathies
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| |-
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| | [[タンパク質凝集]]
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| | protein aggregation、protein aggregate formation
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| |-
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| | [[タンパク質ミスフォールディング]]
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| | protein misfolding
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| |-
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| | [[プロテオスタシス]]
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| | proteostasis、protein homeostasis、タンパク質恒常性
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| |-
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| | [[プリオン様伝播]]
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| | prion-like propagation、prion-like spreading、prion-like transmission、seeded propagation
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| |-
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| | [[ストレス顆粒]]
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| | stress granule、stress granules、SG
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| |-
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| | [[RNA代謝異常と神経変性]]
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| | RNA dysmetabolism in neurodegeneration、RNA metabolism dysfunction
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| |-
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| | [[オートファジー・リソソーム系]]
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| | autophagy-lysosome system、autophagy-lysosomal pathway、ALP
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| |-
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| | [[神経炎症]]
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| | neuroinflammation
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| |-
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| | [[選択的神経細胞脆弱性]]
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| | selective neuronal vulnerability、selective vulnerability
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| |-
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| | [[ミトコンドリア機能障害と神経変性]]
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| | mitochondrial dysfunction in neurodegeneration
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| |-
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| | [[エキサイトトキシシティ]]
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| | excitotoxicity、excitotoxic neuronal death
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| |-
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| | [[フェロトーシス]]
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| | ferroptosis
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|
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| |-
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| ! rowspan="4" | バイオマーカー
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| | [[ニューロフィラメント軽鎖]]
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| | neurofilament light chain、neurofilament light、NfL、NFL、NEFL
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| |-
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| | [[リン酸化タウ]]
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| | phosphorylated tau、phospho-tau、p-tau
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| |-
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| | [[αシヌクレイン・シード増幅アッセイ]]
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| | α-synuclein seed amplification assay、αSyn-SAA、α-synuclein SAA
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| |-
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| | [[Aβ42/Aβ40比]]
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| | amyloid-β 42/40 ratio、Aβ42/Aβ40 ratio
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| |} | | |} |