「BHLH因子」の版間の差分

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=== 発現パターンによる分類<br>  ===
=== 発現パターンによる分類<br>  ===


'''&nbsp; ・'''''<b>Class I&nbsp;: &nbsp;&nbsp;</b>''多くの組織に普遍的に存在 &nbsp; &nbsp; Tcf3 (E12/E47), Tcf4 (E2-2) etc.  
'''&nbsp; ・'''''<b>Class I &nbsp; &nbsp; &nbsp;</b>''多くの組織に普遍的に存在 &nbsp; &nbsp; &nbsp; Tcf3 (E12/E47), Tcf4 (E2-2) etc.  


&nbsp;&nbsp;'''・'''''<b>Class II&nbsp;:&nbsp;</b>'' 組織特異的に発現 &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; MyoD, Neurog (Ngn), Hes etc.  
&nbsp;&nbsp;'''・'''''<b>Class II &nbsp;</b>''&nbsp; &nbsp;組織特異的に発現 &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;MyoD, Neurog (Ngn), Hes etc.  


 組織特異的に発現するbHLH因子 (Class II) の多くはClass IのbHLH因子とへテロダイマーを形成してDNAに結合し転写を活性化する。  
 組織特異的に発現するbHLH因子 (Class II) の多くはClass IのbHLH因子とへテロダイマーを形成してDNAに結合し転写を活性化する。  
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=== 機能的分類(脳神経系における主要機能別分類)  ===
=== 機能的分類(脳神経系における主要機能別分類)  ===


'''''&nbsp;'''''<b></b>'''''Promotion of neuronal differentiation''''' <br>&nbsp; &nbsp;  Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3),  
'''&nbsp;&nbsp;・'''''<b>Promotion of neuronal differentiation</b>'' <br>&nbsp; &nbsp;  Ascl1 (Mash1), Atoh1 (Math1), Ebf1, Ebf2, Ebf3, Ebf4, Hand1, Hand2, Hes6, Neurod1 (Neurod/Beta2), Neurod2 (Ndrf), Neurod4 (Math3),  


&nbsp; &nbsp;  Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1  
&nbsp; &nbsp;  Neurod6 (Math2), Neurog1 (Ngn1), Neurog2 (Ngn2), Ptf1a, Sim1  


'''''&nbsp;'''''<b>・</b>'''''Inhibition of neuronal differentiation''''' <br>&nbsp; &nbsp;  Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3)  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Inhibition of neuronal differentiation''''' <br>&nbsp; &nbsp;  Hes1, Hes3, Hes5, Hey1, Hey2, HeyL (Hey3)  


'''''&nbsp;'''''<b>・</b>'''''Glial differentiation'''''<br>&nbsp; &nbsp;  Olig1, Olig2, Olig3, Tal1 (Scl)  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Glial differentiation'''''<br>&nbsp; &nbsp;  Olig1, Olig2, Olig3, Tal1 (Scl)  


'''''&nbsp;'''''<b>・</b>'''''Cerebellar development'''''<br>&nbsp; &nbsp;  Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Cerebellar development'''''<br>&nbsp; &nbsp;  Atoh1 (Math1), Nhlh1 (Nscl1), Nhlh2 (Nscl2), Ptf1a  


'''''&nbsp;'''''<b>・</b>'''''Autonomic neurogenesis'''''<br>&nbsp; &nbsp;  Ascl1 (Mash1), Hand1, Hand2  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Autonomic neurogenesis'''''<br>&nbsp; &nbsp;  Ascl1 (Mash1), Hand1, Hand2  


'''''&nbsp;'''''<b>・</b>'''''Circadian rhythm'''''<br>&nbsp; &nbsp;  Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Circadian rhythm'''''<br>&nbsp; &nbsp;  Ahr, Ahrr, Arntl (Bmal1), Clock, Bhlhe40 (Dec1), Bhlhe41 (Dec2), Npas, Per, Sim  


'''''&nbsp;'''''<b>・</b>'''''Cell cycle'''''<br>&nbsp; &nbsp;  Myc (c-Myc), Mycn (N-Myc)  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Cell cycle'''''<br>&nbsp; &nbsp;  Myc (c-Myc), Mycn (N-Myc)  


'''''&nbsp;'''''<b>・</b>'''''Cofactor'''''<br>&nbsp; &nbsp;  Tcf3 (E12/E47), Tcf4 (E2-2)<br>  
'''''&nbsp;&nbsp;'''''<b>・</b>'''''Cofactor'''''<br>&nbsp; &nbsp;  Tcf3 (E12/E47), Tcf4 (E2-2)<br>  


*The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the bHLH family&nbsp;(http://www.genenames.org/genefamily/bhlh.php)
*The HUGO Gene Nomenclature Committee (HGNC) provides a list of genes in the bHLH family&nbsp;(http://www.genenames.org/genefamily/bhlh.php)
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