テンプレート:PBB/3084

Neuregulin 1
PDB rendering based on 1hae.
Available structures PDB 1HAE​, 1HAF​, 1HRE​, 1HRF​
Identifiers
Symbols	NRG1; ARIA; GGF; GGF2; HGL; HRG; HRG1; HRGA; MST131; NDF; SMDF
External IDs	OMIM: 142445 MGI: 96083 HomoloGene: 8509 GeneCards: NRG1 Gene
Gene Ontology Molecular function • transcription cofactor activity • receptor binding • cytokine activity • protein binding • growth factor activity • growth factor activity • protein tyrosine kinase activator activity • transmembrane receptor protein tyrosine kinase activator activity • transmembrane receptor protein tyrosine kinase activator activity • receptor tyrosine kinase binding • ErbB-3 class receptor binding • ErbB-3 class receptor binding Cellular component • extracellular region • extracellular space • nucleus • plasma membrane • membrane • integral to membrane • apical plasma membrane Biological process • anti-apoptosis • cell communication • transmembrane receptor protein tyrosine kinase signaling pathway • activation of transmembrane receptor protein tyrosine kinase activity • Notch signaling pathway • nervous system development • cell proliferation • embryo development • negative regulation of cardiac muscle cell apoptosis • neural crest cell development • positive regulation of cell growth • mammary gland development • wound healing • wound healing • regulation of protein homodimerization activity • regulation of protein heterodimerization activity • cellular protein complex disassembly • positive regulation of cell adhesion • negative regulation of transcription, DNA-dependent • negative regulation of secretion • positive regulation of striated muscle cell differentiation • cardiac muscle cell differentiation • ventricular cardiac muscle cell differentiation • positive regulation of cardiac muscle cell proliferation • positive regulation of protein tyrosine kinase activity Sources: Amigo / QuickGO
RNA expression pattern
[[file: PBB GE NRG1 206343 s at fs |250px]]
[[file:[Nrg1]|250px]]
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3084	211323
Ensembl	ENSG00000157168	ENSMUSG00000062991
UniProt	Q02297	n/a
RefSeq (mRNA)	NM_001159995.1	NM_178591.2
RefSeq (protein)	NP_001153467.1	NP_848706.2
Location (UCSC)	Chr 8: 31.5 – 32.62 Mb	Chr 8: 32.93 – 33.12 Mb
PubMed search	[1]	[2]