「ROCK」の版間の差分

10行目:

同義語：Rhoキナーゼ

{{box|text=　ROCKは活性型の低分子量GTP結合タンパク質Rhoにより活性化される分子量約160 kDaのセリン・スレオニンタンパク質リン酸化酵素であり、哺乳類にはROCK-IとROCK-IIの2つのアイソフォームが存在する。ROCKはミオシン軽鎖とミオシン軽鎖脱リン酸化酵素のリン酸化を介してミオシン軽鎖を活性化する。さらに、LIMキナーゼのリン酸化を介してアクチン脱重合因子であるコフィリンを不活化し、アクチン脱重合を抑制する。これらの作用が協調して、Rho依存的なアクトミオシン束の形成を促す。その他にもROCKは数多くの基質をリン酸化して、細胞運動、細胞極性、細胞接着、細胞分裂、アポトーシス、転写制御など多様な生命機能に関わる<ref name=ref1><pubmed>12778124</pubmed></ref> <ref name=ref2><pubmed>20803696</pubmed></ref>。神経系においても、発生・発達期における神経管形成、神経突起伸展制御、シナプス形成に加え、成体でのシナプス可塑性に至るまで幅広い役割を担う。}}

{{~~box~~|text=　~~ROCKは活性型の低分子量GTP結合タンパク質Rhoにより活性化される分子量約160 kDaのセリン・スレオニンタンパク質リン酸化酵素であり、哺乳類にはROCK~~-~~IとROCK~~-IIの2つのアイソフォームが存在する。ROCKはミオシン軽鎖とミオシン軽鎖脱リン酸化酵素のリン酸化を介してミオシン軽鎖を活性化する。さらに、LIMキナーゼのリン酸化を介してアクチン脱重合因子であるコフィリンを不活化し、アクチン脱重合を抑制する。これらの作用が協調して、Rho依存的なアクトミオシン束の形成を促す。その他にもROCKは数多くの基質をリン酸化して、細胞運動、細胞極性、細胞接着、細胞分裂、アポトーシス、転写制御など多様な生命機能に関わる<ref name=~~ref1><pubmed>12778124</pubmed></ref> <ref name~~=~~ref2><pubmed>20803696</pubmed><~~/ref>。神経系においても、発生・発達期における神経管形成、神経突起伸展制御、シナプス形成に加え、成体でのシナプス可塑性に至るまで幅広い役割を担う。}}

{{GNF_Protein_box

| Name = Rho-associated, coiled-coil containing protein kinase 1

| image = Protein_ROCK1_PDB_1s1c.png

| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s1c.

| PDB = {{PDB2|1S1C}}, {{PDB2|2ESM}}, {{PDB2|2ETK}}, {{PDB2|2ETR}}, {{PDB2|2V55}}, {{PDB2|3D9V}}, {{PDB2|3NCZ}}, {{PDB2|3NDM}}, {{PDB2|3O0Z}}, {{PDB2|3TV7}}, {{PDB2|3TWJ}}, {{PDB2|3V8S}}, {{PDB2|4L2W}}, {{PDB2|4W7P}}

| HGNCid = 10251

| MGIid = 107927

| Symbol = ROCK1

| AltSymbols =; P160ROCK; ROCK-I

| IUPHAR =

| ChEMBL = 3231

| OMIM = 601702

| ECnumber = 2.7.11.1

| Homologene = 55899

| GeneAtlas_image1 =

| GeneAtlas_image2 =

| GeneAtlas_image3 =

| Protein_domain_image =

| Function = {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017049 |text = GTP-Rho binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}

| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005814 |text = centriole}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}} {{GNF_GO|id=GO:0032059 |text = bleb}}

| Process = {{GNF_GO|id=GO:0003383 |text = apical constriction}} {{GNF_GO|id=GO:0006468 |text = protein phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptotic process}} {{GNF_GO|id=GO:0006921 |text = cellular component disassembly involved in execution phase of apoptosis}} {{GNF_GO|id=GO:0006939 |text = smooth muscle contraction}} {{GNF_GO|id=GO:0007159 |text = leukocyte cell-cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0012501 |text = programmed cell death}} {{GNF_GO|id=GO:0016525 |text = negative regulation of angiogenesis}} {{GNF_GO|id=GO:0022614 |text = membrane to membrane docking}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0032060 |text = bleb assembly}} {{GNF_GO|id=GO:0032091 |text = negative regulation of protein binding}} {{GNF_GO|id=GO:0032956 |text = regulation of actin cytoskeleton organization}} {{GNF_GO|id=GO:0043524 |text = negative regulation of neuron apoptotic process}} {{GNF_GO|id=GO:0045616 |text = regulation of keratinocyte differentiation}} {{GNF_GO|id=GO:0048010 |text = vascular endothelial growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0048013 |text = ephrin receptor signaling pathway}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}} {{GNF_GO|id=GO:0050901 |text = leukocyte tethering or rolling}} {{GNF_GO|id=GO:0051451 |text = myoblast migration}} {{GNF_GO|id=GO:0051492 |text = regulation of stress fiber assembly}} {{GNF_GO|id=GO:0051893 |text = regulation of focal adhesion assembly}} {{GNF_GO|id=GO:0051894 |text = positive regulation of focal adhesion assembly}} {{GNF_GO|id=GO:2000114 |text = regulation of establishment of cell polarity}} {{GNF_GO|id=GO:2000145 |text = regulation of cell motility}}

| Hs_EntrezGene = 6093

| Hs_Ensembl = ENSG00000067900

| Hs_RefseqmRNA = NM_005406

| Hs_RefseqProtein = NP_005397

| Hs_GenLoc_db = hg38

| Hs_GenLoc_chr = 18

| Hs_GenLoc_start = 20946906

| Hs_GenLoc_end = 21111851

| Hs_Uniprot = Q13464

| Mm_EntrezGene = 19877

| Mm_Ensembl = ENSMUSG00000024290

| Mm_RefseqmRNA = NM_009071

| Mm_RefseqProtein = NP_033097

| Mm_GenLoc_db = mm10

| Mm_GenLoc_chr = 18

| Mm_GenLoc_start = 10064401

| Mm_GenLoc_end = 10181792

| Mm_Uniprot = P70335

| path = PBB/6093

}}

==はじめに==

「ROCK」の版間の差分

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