「テスト」の版間の差分

提供：脳科学辞典
ナビゲーションに移動 検索に移動
細編集の要約なし
細編集の要約なし
1行目: 1行目:
{| style="width: 619px; height: 1446px;" border="1" cellspacing="1" cellpadding="1"
{| style="width: 619px; height: 1446px" border="1" cellspacing="1" cellpadding="1"
|+ 表1 主なS-パルミトイル化タンパク質<br>  
|+ 表1 主なS-パルミトイル化タンパク質<br>
{| style="width: 587px; height: 457px;" border="1" cellspacing="1" cellpadding="1"
{| style="width: 587px; height: 457px" border="1" cellspacing="1" cellpadding="1"
|-
|-
| ファミリー<br>  
| ファミリー<br>
| 主な例<br>
| 主な例<br>
|-
|-
| '''Signalling protein'''<br>　Small GTPase<br>　Gα subunit<br>　Src family<br>　Others<br>  
| '''Signalling protein'''<br>　Small GTPase<br>　Gα subunit<br>　Src family<br>　Others<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br>
|-
|-
|  
|  
'''Transmembrane'''<br>　Ion channel<br>　GPCR<br>　Cell adhesion molecule<br>　Transporter<br>　Matrix metalloproteinase<br>　Myelin associated<br>　Secretase<br>　Cell death signalling<br>  
'''Transmembrane'''<br>　Ion channel<br>　GPCR<br>　Cell adhesion molecule<br>　Transporter<br>　Matrix metalloproteinase<br>　Myelin associated<br>　Secretase<br>　Cell death signalling<br>


| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
|-
|-
| '''Adaptor, Scaffold'''<br>  
| '''Adaptor, Scaffold'''<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br>
|-
|-
| '''Viral protein'''<br>  
| '''Viral protein'''<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
|-
|-
| '''N-palmitoylated protein'''<br>  
| '''N-palmitoylated protein'''<br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
| Sonic Hedgehog, Wnt, Ghrelin <br>
|}
|}


<br>  
<br>


<br>  
<br>


表２ パルミチルトランスフェラーゼ  
表２ パルミチルトランスフェラーゼ  
<br>




41行目: 43行目:
| DHHC1  
| DHHC1  
| ZDHHC1  
| ZDHHC1  
| <br>  
| <br>
| ER  
| ER  
| <br>
| <br>
47行目: 49行目:
| DHHC2  
| DHHC2  
| ZDHHC2  
| ZDHHC2  
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>  
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| 癌<br>
| 癌<br>
|-
|-
| DHHC3<br>  
| DHHC3<br>
|  
|  
ZDHHC3  
ZDHHC3  


GODZ<br>  
GODZ<br>


| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>  
| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC4<br>  
| DHHC4<br>
| ZDHHC4<br>  
| ZDHHC4<br>
| BACE1<br>  
| BACE1<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC5<br>  
| DHHC5<br>
| ZDHHC5<br>  
| ZDHHC5<br>
| STREX<br>  
| STREX<br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| DHHC6<br>  
| DHHC6<br>
| ZDHHC6<br>  
| ZDHHC6<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| DHHC7<br>  
| DHHC7<br>
| ZDHHC7<br>  
| ZDHHC7<br>
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>  
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC8<br>  
| DHHC8<br>
| ZDHHC8<br>  
| ZDHHC8<br>
| PSD95, SNAP25, eNOS, paralemmin-1<br>  
| PSD95, SNAP25, eNOS, paralemmin-1<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| 統合失調症<br>
| 統合失調症<br>
|-
|-
| DHHC9'''<br>'''  
| DHHC9'''<br>'''
| ZDHHC9<br>  
| ZDHHC9<br>
| H-RAS, N-Ras<br>  
| H-RAS, N-Ras<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| 癌、X連鎖神経遅滞<br>
| 癌、X連鎖神経遅滞<br>
|-
|-
| DHHC10<br>  
| DHHC10<br>
| ZDHHC11<br>  
| ZDHHC11<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC11<br>  
| DHHC11<br>
| ZDHHC23<br>NIDD<br>  
| ZDHHC23<br>NIDD<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| 癌<br>
| 癌<br>
|-
|-
| DHHC12<br>  
| DHHC12<br>
| ZDHHC12<br>  
| ZDHHC12<br>
| ABC transporter A1<br>  
| ABC transporter A1<br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC13<br>  
| DHHC13<br>
| ZDHHC24<br>  
| ZDHHC24<br>
| huntingtin<br>  
| huntingtin<br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC14<br>  
| DHHC14<br>
| ZDHHC14<br>  
| ZDHHC14<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC15<br>  
| DHHC15<br>
| ZDHHC15<br>  
| ZDHHC15<br>
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>  
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br>
| ゴルジ体<br>  
| ゴルジ体<br>
| X連鎖神経遅滞<br>
| X連鎖神経遅滞<br>
|-
|-
| DHHC16<br>  
| DHHC16<br>
| ZDHHC16<br>  
| ZDHHC16<br>
| <br>  
| <br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC17<br>  
| DHHC17<br>
|  
|  
ZDHHC17  
ZDHHC17  


HIP14<br>  
HIP14<br>


| SNAP25, huntingtin, <br>  
| SNAP25, huntingtin, <br>
| ゴルジ体<br>  
| ゴルジ体<br>
| ハンチントン病、癌<br>
| ハンチントン病、癌<br>
|-
|-
| DHHC18<br>  
| DHHC18<br>
| ZDHHC18<br>  
| ZDHHC18<br>
| <br>  
| <br>
| ゴルジ体<br>  
| ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC19<br>  
| DHHC19<br>
| ZDHHC19<br>  
| ZDHHC19<br>
| R-Ras<br>  
| R-Ras<br>
| ER<br>  
| ER<br>
| <br>
| <br>
|-
|-
| DHHC20<br>  
| DHHC20<br>
| ZDHHC20<br>  
| ZDHHC20<br>
| BACE1, ABC transporter 1<br>  
| BACE1, ABC transporter 1<br>
| 細胞膜<br>  
| 細胞膜<br>
| <br>
| <br>
|-
|-
| DHHC21<br>  
| DHHC21<br>
| ZDHHC21<br>  
| ZDHHC21<br>
| eNOS, Lck, Fyn, ABC transporter 1<br>  
| eNOS, Lck, Fyn, ABC transporter 1<br>
| 細胞膜<br>  
| 細胞膜<br>
| <br>
| <br>
|-
|-
| DHHC22<br>  
| DHHC22<br>
| ZDHHC13<br>  
| ZDHHC13<br>
| <br>  
| <br>
| ER/ゴルジ体<br>  
| ER/ゴルジ体<br>
| <br>
| <br>
|-
|-
| DHHC23<br>  
| DHHC23<br>
| ZDHHC25<br>  
| ZDHHC25<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|-
|-
| <br>  
| <br>
| ZDHHC22<br>  
| ZDHHC22<br>
| <br>  
| <br>
| <br>  
| <br>
| <br>
| <br>
|}
|}


&nbsp; <br>
&nbsp; <br>
{| style="width: 618px; height: 1074px" border="1" cellspacing="1" cellpadding="1" width="618"
|-
| Category
| Family
| N-Myristoylated protein
|-
| Kinase/Phosphatase
| Src family kinase
| Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
|-
|
| Abl tyrosine kinase
| c-Abl, Arg
|-
| <br>
| Ser/Thr kinase
| cAMP-dependent protein kinase, AKAP18
|-
| <br>
| phosphatase
| Calcineurin B
|-
| GTP-binding protein
| Gα
| Gα i1, Gαo, Gαt, Gαx
|-
|
| ADP-ribosylation factor
| Arf-1, Arf-3, Arf-5, Arf-6
|-
| Ca2+ binding /<br>EF hand protein
|
| Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,<br>Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
|-
| Membrane/cytoskeletal-<br>bound protein
|
| MARCKS, Annexin　XIII, <br>Rapsyn, Pallidin, Hisactophilin 2
|-
| Viral protein
| Gag protein
| HIV-1, Moloney murine, sarcoma virus, Friend murine,<br>leukemia virus
|-
|
| Others
| HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,<br>Herpes simplex virus
|-
| Others
|
| eNOS
|-
| Caspase-cleavage <br>post-translational<br>N-myristoylated protein
|
| β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,<br>MST3, PKC,
|}

2012年1月22日 (日) 17:54時点における版

表1 主なS-パルミトイル化タンパク質
ファミリー
 主な例
Signalling protein
　Small GTPase
　Gα subunit
　Src family
　Others
H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10
Gαs, Gαq, Gαi2
Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk
GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2

Transmembrane
　Ion channel
　GPCR
　Cell adhesion molecule
　Transporter
　Matrix metalloproteinase
　Myelin associated
　Secretase
　Cell death signalling

 GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1
Rhodopsin, β2-adrenergic receptor,
Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC
EAAT1, EAAT3
MT1-MMP
PLP, GPM6A
β-secretase, Nicastrin
Fas, NGFR
Adaptor, Scaffold
 PSD95, PSD93α/β, GRIP1/2, Delphilin
Viral protein
 Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160
N-palmitoylated protein
 Sonic Hedgehog, Wnt, Ghrelin



表２ パルミチルトランスフェラーゼ



酵素 別名 主な基質 局在（過剰発現系） 関連疾患
DHHC1 ZDHHC1
ER
DHHC2 ZDHHC2 PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1
 ER/ゴルジ体
 癌
DHHC3

ZDHHC3

GODZ

 PSD95, SNAP25, Gαs, GABAAγ2, eNOS,
 ゴルジ体
DHHC4
 ZDHHC4
 BACE1
 ゴルジ体
DHHC5
 ZDHHC5
 STREX

DHHC6
 ZDHHC6


DHHC7
 ZDHHC7
 PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS
 ゴルジ体
DHHC8
 ZDHHC8
 PSD95, SNAP25, eNOS, paralemmin-1
 ゴルジ体
 統合失調症
DHHC9
 		ZDHHC9
 H-RAS, N-Ras
 ER/ゴルジ体
 癌、X連鎖神経遅滞
DHHC10
 ZDHHC11
ER
DHHC11
 ZDHHC23
NIDD
ER
 癌
DHHC12
 ZDHHC12
 ABC transporter A1
 ER/ゴルジ体
DHHC13
 ZDHHC24
 huntingtin
 ER
DHHC14
 ZDHHC14
ER
DHHC15
 ZDHHC15
 PSD95, GAP43, GABAAγ2, BACE1, CD151
 ゴルジ体
 X連鎖神経遅滞
DHHC16
 ZDHHC16
ER
DHHC17

ZDHHC17

HIP14

 SNAP25, huntingtin,
ゴルジ体
 ハンチントン病、癌
DHHC18
 ZDHHC18
ゴルジ体
DHHC19
 ZDHHC19
 R-Ras
 ER
DHHC20
 ZDHHC20
 BACE1, ABC transporter 1
 細胞膜
DHHC21
 ZDHHC21
 eNOS, Lck, Fyn, ABC transporter 1
 細胞膜
DHHC22
 ZDHHC13
ER/ゴルジ体
DHHC23
 ZDHHC25



ZDHHC22


 


Category Family N-Myristoylated protein
Kinase/Phosphatase Src family kinase Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
Abl tyrosine kinase c-Abl, Arg

Ser/Thr kinase cAMP-dependent protein kinase, AKAP18

phosphatase Calcineurin B
GTP-binding protein Gα Gα i1, Gαo, Gαt, Gαx
ADP-ribosylation factor Arf-1, Arf-3, Arf-5, Arf-6
Ca2+ binding /
EF hand protein 		Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,
Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
Membrane/cytoskeletal-
bound protein 		MARCKS, Annexin　XIII,
Rapsyn, Pallidin, Hisactophilin 2
Viral protein Gag protein HIV-1, Moloney murine, sarcoma virus, Friend murine,
leukemia virus
Others HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,
Herpes simplex virus
Others eNOS
Caspase-cleavage
post-translational
N-myristoylated protein 		β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,
MST3, PKC,
「https://bsd.neuroinf.jp/w/index.php?title=テスト&oldid=1729」から取得