「Δ4-Tibolone」の版間の差分

Δ4-Tibolone
ファイル:Δ4-Tibolone.svg
ファイル:Δ4-Tibolone molecule ball.png
Systematic (IUPAC) name
	(7R,8R,9S,10R,13S,14S,17R)-17-Ethynyl-17-hydroxy-7,13-dimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1162-60-3
ATC code	?
PubChem	CID 22814761
ChemSpider	18532860
UNII	LHZ8R2OW0M
Synonyms	ORG-OM-38; Delta-4-Tibolone; 7α-Methylnorethisterone; 7α-Methyl-17α-ethynyl-19-nortestosterone; 17α-Ethynyl-17β-hydroxy-7α-methyl-4-estren-3-one
Chemical data
Formula	C21H28O2
	InChI InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,12-13,16-19,23H,5-11H2,2-3H3/t13-,16+,17-,18+,19-,20+,21+/m1/s1; Key:WAOKMNBZWBGYIK-KIURNNQRSA-N;

2025年3月18日 (火) 19:35時点における最新版

δ⁴-Tibolone (developmental code name ORG-OM-38), also known as 7α-methylnorethisterone or as 7α-methyl-17α-ethynyl-19-nortestosterone, is a synthetic androgen and progestin which was never marketed.^[1]^[2] The compound is a major active metabolite of tibolone, which itself is a prodrug of δ⁴-tibolone along with 3α-hydroxytibolone and 3β-hydroxytibolone (which, in contrast to δ⁴-tibolone, are estrogens).^[1] Tibolone and δ⁴-tibolone are thought to be responsible for the androgenic and progestogenic activity of tibolone, while 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for its estrogenic activity.^[1]

References

↑ ^{以下の位置に戻る: 1.0} ^1.1 ^1.2 Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. PMID 16112947. S2CID 24616324.
↑ Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167. S2CID 18346113.

テンプレート:Androgen receptor modulators テンプレート:Progesterone receptor modulators

テンプレート:Genito-urinary-drug-stub テンプレート:Steroid-stub

[pmid16112947-1] {以下の位置に戻る: 1.0} ^1.1 ^1.2 Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration" (PDF). Climacteric. 8 (Suppl 1): 3–63. doi:10.1080/13697130500148875. PMID 16112947. S2CID 24616324.

[pmid19464167-2] Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167. S2CID 18346113.

[1]

[2]

「Δ4-Tibolone」の版間の差分

2025年3月18日 (火) 19:35時点における最新版

See also

References

案内メニュー

「Δ4-Tibolone」の版間の差分

2025年3月18日 (火) 19:35時点における最新版

See also

References

案内メニュー

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