テンプレート:PBB/1950

Epidermal growth factor
Rainbow colored NMR structure (N-terminus = blue, C-terminus = red) of the mouse epidermal growth factor.
Available structures PDB 1IVO​, 1JL9​, 1NQL​, 1P9J​, 3NJP​
Identifiers
Symbols	EGF; HOMG4; URG
External IDs	OMIM: 131530 MGI: 95290 HomoloGene: 1483 GeneCards: EGF Gene
Gene Ontology Molecular function • epidermal growth factor receptor binding • calcium ion binding • protein binding • growth factor activity • transmembrane receptor protein tyrosine kinase activator activity Cellular component • extracellular region • extracellular region • extracellular space • soluble fraction • plasma membrane • integral to membrane • platelet alpha granule lumen Biological process • activation of MAPKK activity • angiogenesis • platelet degranulation • DNA replication • signal transduction • activation of transmembrane receptor protein tyrosine kinase activity • epidermal growth factor receptor signaling pathway • STAT protein import into nucleus • blood coagulation • positive regulation of cell proliferation • positive regulation of peptidyl-threonine phosphorylation • positive regulation of cerebellar granule cell precursor proliferation • platelet activation • positive regulation of catenin import into nucleus • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of phosphorylation • positive regulation of DNA binding • positive regulation of MAP kinase activity • positive regulation of epidermal growth factor-activated receptor activity • positive regulation of epidermal growth factor-activated receptor activity • positive regulation of mitosis • positive regulation of transcription, DNA-dependent • branching morphogenesis of a tube • regulation of protein secretion • regulation of peptidyl-tyrosine phosphorylation • negative regulation of secretion • mammary gland alveolus development • ERK1 and ERK2 cascade • regulation of calcium ion import • negative regulation of cholesterol efflux • regulation of protein localization at cell surface • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1950	13645
Ensembl	ENSG00000138798	ENSMUSG00000028017
UniProt	P01133	P01132
RefSeq (mRNA)	NM_001178130.1	NM_010113.3
RefSeq (protein)	NP_001171601.1	NP_034243.2
Location (UCSC)	Chr 4: 110.83 – 110.93 Mb	Chr 3: 129.38 – 129.46 Mb
PubMed search	[1]	[2]