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|+ 表1 主なS-パルミトイル化タンパク質
| ファミリー |
主な例 |
| Signalling protein Small GTPase Gα subunit Src family Others |
H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10 Gαs, Gαq, Gαi2 Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2 |
|
Transmembrane |
GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1 Rhodopsin, β2-adrenergic receptor, Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC EAAT1, EAAT3 MT1-MMP PLP, GPM6A β-secretase, Nicastrin Fas, NGFR |
| Adaptor, Scaffold |
PSD95, PSD93α/β, GRIP1/2, Delphilin |
| Viral protein |
Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160 |
| N-palmitoylated protein |
Sonic Hedgehog, Wnt, Ghrelin |
| 酵素 | 別名 | 主な基質 | 局在（過剰発現系） | 関連疾患 |
|---|---|---|---|---|
| DHHC1 | ZDHHC1 | ER | ||
| DHHC2 | ZDHHC2 | PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1 |
ER/ゴルジ体 |
癌 |
| DHHC3 |
ZDHHC3 GODZ |
PSD95, SNAP25, Gαs, GABAAγ2, eNOS, |
ゴルジ体 |
|
| DHHC4 |
ZDHHC4 |
BACE1 |
ゴルジ体 |
|
| DHHC5 |
ZDHHC5 |
STREX |
||
| DHHC6 |
ZDHHC6 |
|||
| DHHC7 |
ZDHHC7 |
PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS |
ゴルジ体 |
|
| DHHC8 |
ZDHHC8 |
PSD95, SNAP25, eNOS, paralemmin-1 |
ゴルジ体 |
統合失調症 |
| DHHC9 |
ZDHHC9 |
H-RAS, N-Ras |
ER/ゴルジ体 |
癌、X連鎖神経遅滞 |
| DHHC10 |
ZDHHC11 |
ER |
||
| DHHC11 |
ZDHHC23 NIDD |
ER |
癌 | |
| DHHC12 |
ZDHHC12 |
ABC transporter A1 |
ER/ゴルジ体 |
|
| DHHC13 |
ZDHHC24 |
huntingtin |
ER |
|
| DHHC14 |
ZDHHC14 |
ER |
||
| DHHC15 |
ZDHHC15 |
PSD95, GAP43, GABAAγ2, BACE1, CD151 |
ゴルジ体 |
X連鎖神経遅滞 |
| DHHC16 |
ZDHHC16 |
ER |
||
| DHHC17 |
ZDHHC17 HIP14 |
SNAP25, huntingtin, |
ゴルジ体 |
ハンチントン病、癌 |
| DHHC18 |
ZDHHC18 |
ゴルジ体 |
||
| DHHC19 |
ZDHHC19 |
R-Ras |
ER |
|
| DHHC20 |
ZDHHC20 |
BACE1, ABC transporter 1 |
細胞膜 |
|
| DHHC21 |
ZDHHC21 |
eNOS, Lck, Fyn, ABC transporter 1 |
細胞膜 |
|
| DHHC22 |
ZDHHC13 |
ER/ゴルジ体 |
||
| DHHC23 |
ZDHHC25 |
|||
| ZDHHC22 |
| Category | Family | N-Myristoylated protein |
| Kinase/Phosphatase | Src family kinase | Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk |
| Abl tyrosine kinase | c-Abl, Arg | |
| Ser/Thr kinase | cAMP-dependent protein kinase, AKAP18 | |
| phosphatase | Calcineurin B | |
| GTP-binding protein | Gα | Gα i1, Gαo, Gαt, Gαx |
| ADP-ribosylation factor | Arf-1, Arf-3, Arf-5, Arf-6 | |
| Ca2+ binding / EF hand protein |
Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22, Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1 | |
| Membrane/cytoskeletal- bound protein |
MARCKS, Annexin XIII, Rapsyn, Pallidin, Hisactophilin 2 | |
| Viral protein | Gag protein | HIV-1, Moloney murine, sarcoma virus, Friend murine, leukemia virus |
| Others | HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16, Herpes simplex virus | |
| Others | eNOS | |
| Caspase-cleavage post-translational N-myristoylated protein |
β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL, MST3, PKC, |