テンプレート:PBB/50944

SH3 and multiple ankyrin repeat domains 1
Available structures PDB 1q3o​, 1q3p​
Identifiers
Symbols	SHANK1; SPANK-1; SSTRIP; synamon
External IDs	OMIM: 604999 MGI: 3613677 HomoloGene: 22949 GeneCards: SHANK1 Gene
Gene Ontology Molecular function • protein binding • protein C-terminus binding • SH3 domain binding • GKAP/Homer scaffold activity • somatostatin receptor binding • ionotropic glutamate receptor binding • identical protein binding • ankyrin repeat binding • scaffold protein binding Cellular component • intracellular • membrane fraction • cytoplasm • plasma membrane • postsynaptic density • cell junction • dendrite • postsynaptic membrane • excitatory synapse Biological process • protein complex assembly • cytoskeletal anchoring at plasma membrane • nervous system development • long-term memory • associative learning • cell differentiation • protein localization to synapse • neuromuscular process controlling balance • dendritic spine morphogenesis • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity • positive regulation of excitatory postsynaptic membrane potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50944	243961
Ensembl	ENSG00000161681	ENSMUSG00000038738
UniProt	Q9Y566	D3YZU1
RefSeq (mRNA)	NM_016148.2	NM_001034115.1
RefSeq (protein)	NP_057232.2	NP_001029287.1
Location (UCSC)	Chr 19: 51.17 – 51.22 Mb	Chr 7: 51.57 – 51.61 Mb
PubMed search	[1]	[2]