テスト

表1 主なS-パルミトイル化タンパク質

ファミリー	主な例
Signalling protein 　Small GTPase 　Gα subunit 　Src family 　Others	H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10 Gαs, Gαq, Gαi2 Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2
Transmembrane 　Ion channel 　GPCR 　Cell adhesion molecule 　Transporter 　Matrix metalloproteinase 　Myelin associated 　Secretase 　Cell death signalling	GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1 Rhodopsin, β2-adrenergic receptor, Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC EAAT1, EAAT3 MT1-MMP PLP, GPM6A β-secretase, Nicastrin Fas, NGFR
Adaptor, Scaffold	PSD95, PSD93α/β, GRIP1/2, Delphilin
Viral protein	Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160
N-palmitoylated protein	Sonic Hedgehog, Wnt, Ghrelin

表２ パルミチルトランスフェラーゼ

酵素	別名	主な基質	局在（過剰発現系）	関連疾患
DHHC1	ZDHHC1		ER
DHHC2	ZDHHC2	PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1	ER/ゴルジ体	癌
DHHC3	ZDHHC3 GODZ	PSD95, SNAP25, Gαs, GABAAγ2, eNOS,	ゴルジ体
DHHC4	ZDHHC4	BACE1	ゴルジ体
DHHC5	ZDHHC5	STREX
DHHC6	ZDHHC6
DHHC7	ZDHHC7	PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS	ゴルジ体
DHHC8	ZDHHC8	PSD95, SNAP25, eNOS, paralemmin-1	ゴルジ体	統合失調症
DHHC9	ZDHHC9	H-RAS, N-Ras	ER/ゴルジ体	癌、X連鎖神経遅滞
DHHC10	ZDHHC11		ER
DHHC11	ZDHHC23 NIDD		ER	癌
DHHC12	ZDHHC12	ABC transporter A1	ER/ゴルジ体
DHHC13	ZDHHC24	huntingtin	ER
DHHC14	ZDHHC14		ER
DHHC15	ZDHHC15	PSD95, GAP43, GABAAγ2, BACE1, CD151	ゴルジ体	X連鎖神経遅滞
DHHC16	ZDHHC16		ER
DHHC17	ZDHHC17 HIP14	SNAP25, huntingtin,	ゴルジ体	ハンチントン病、癌
DHHC18	ZDHHC18		ゴルジ体
DHHC19	ZDHHC19	R-Ras	ER
DHHC20	ZDHHC20	BACE1, ABC transporter 1	細胞膜
DHHC21	ZDHHC21	eNOS, Lck, Fyn, ABC transporter 1	細胞膜
DHHC22	ZDHHC13		ER/ゴルジ体
DHHC23	ZDHHC25
	ZDHHC22

 

Category	Family	N-Myristoylated protein
Kinase/Phosphatase	Src family kinase	Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
	Abl tyrosine kinase	c-Abl, Arg
	Ser/Thr kinase	cAMP-dependent protein kinase, AKAP18
	phosphatase	Calcineurin B
GTP-binding protein	Gα	Gα i1, Gαo, Gαt, Gαx
	ADP-ribosylation factor	Arf-1, Arf-3, Arf-5, Arf-6
Ca2+ binding / EF hand protein		Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22, Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
Membrane/cytoskeletal- bound protein		MARCKS, Annexin　XIII, Rapsyn, Pallidin, Hisactophilin 2
Viral protein	Gag protein	HIV-1, Moloney murine, sarcoma virus, Friend murine, leukemia virus
	Others	HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16, Herpes simplex virus
Others		eNOS
Caspase-cleavage post-translational N-myristoylated protein		β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL, MST3, PKC,