テンプレート:PBB/3060

Orexin neuropeptide
Solution phase NMR structure of orexin A based on the PDB coordinates 1R02​.
Available structures PDB 1CQ0​, 1R02​, 1UVQ​, 1WSO​
Identifiers
Symbols	HCRT; NRCLP1; OX; PPOX
External IDs	OMIM: 602358 HomoloGene: 1166 GeneCards: HCRT Gene
Gene Ontology Molecular function • neuropeptide hormone activity • type 1 hypocretin receptor binding • type 2 hypocretin receptor binding Cellular component • extracellular region • rough endoplasmic reticulum • synaptic vesicle • cell junction • secretory granule • perinuclear region of cytoplasm Biological process • phospholipase C-activating G-protein coupled receptor signaling pathway • elevation of cytosolic calcium ion concentration • protein kinase C-activating G-protein coupled receptor signaling pathway • neuropeptide signaling pathway • synaptic transmission • negative regulation of DNA replication • eating behavior • negative regulation of potassium ion transport • regulation of neurotransmitter secretion • positive regulation of calcium ion transport • negative regulation of transmission of nerve impulse • positive regulation of transmission of nerve impulse • regulation of excitatory postsynaptic membrane potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3060	15171
Ensembl	ENSG00000161610	ENSMUSG00000045471
UniProt	O43612	O55241
RefSeq (mRNA)	NM_001524	NM_010410
RefSeq (protein)	NP_001515	NP_034540
Location (UCSC)	Chr 17: 40.34 – 40.34 Mb	Chr 11: 100.76 – 100.76 Mb
PubMed search	[1]	[2]