テンプレート:PBB/1020

Cyclin-dependent kinase 5 <jmol> <size>320</size> <jmolPdb>1ALE</jmolPdb> </jmol>
Available structures PDB 1H4L​, 1UNG​, 1UNH​, 1UNL​, 3O0G​, 4AU8​
Identifiers
Symbols	CDK5; PSSALRE
External IDs	OMIM: 123831 MGI: 101765 HomoloGene: 3623 GeneCards: CDK5 Gene
EC number	2.7.11.22
Gene Ontology Molecular function • p53 binding • protein kinase activity • protein serine/threonine kinase activity • cyclin-dependent protein serine/threonine kinase activity • ErbB-2 class receptor binding • protein binding • ATP binding • kinase activity • acetylcholine receptor activator activity • ErbB-3 class receptor binding • ephrin receptor binding • tau-protein kinase activity Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • postsynaptic density • membrane • cyclin-dependent protein kinase 5 holoenzyme complex • lamellipodium • cell junction • filopodium • axon • dendrite • growth cone • neuromuscular junction • neuronal cell body • perikaryon • postsynaptic membrane Biological process • neuron migration • synaptic transmission, dopaminergic • intracellular protein transport • nucleocytoplasmic transport • cell-matrix adhesion • synaptic transmission • axon guidance • synapse assembly • skeletal muscle tissue development • blood coagulation • motor neuron axon guidance • cell proliferation • visual learning • embryo development • Schwann cell development • synaptic vesicle exocytosis • phosphorylation • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • sensory perception of pain • cerebellar cortex formation • hippocampus development • layer formation in cerebral cortex • central nervous system neuron development • corpus callosum development • neuron differentiation • regulation of cell migration • cortical actin cytoskeleton organization • neuron projection development • negative regulation of protein ubiquitination • negative regulation of synaptic plasticity • positive regulation of protein binding • receptor catabolic process • serine phosphorylation of STAT3 protein • synaptic transmission, glutamatergic • protein localization to synapse • regulation of apoptotic process • receptor clustering • positive regulation of neuron apoptotic process • regulated secretory pathway • negative regulation of cell cycle • positive regulation of protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of calcium ion-dependent exocytosis • protein autophosphorylation • negative regulation of protein export from nucleus • behavioral response to cocaine • regulation of synaptic plasticity • synaptic vesicle endocytosis • axon extension • oligodendrocyte differentiation • dendrite morphogenesis • cell division • neuron apoptotic process • regulation of excitatory postsynaptic membrane potential • regulation of dendritic spine morphogenesis • calcium ion import • regulation of cell cycle arrest • positive regulation of protein targeting to membrane • positive regulation of actin cytoskeleton reorganization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1020	12568
Ensembl	ENSG00000164885	ENSMUSG00000028969
UniProt	Q00535	P49615
RefSeq (mRNA)	NM_001164410	NM_007668
RefSeq (protein)	NP_001157882	NP_031694
Location (UCSC)	Chr 7: 150.75 – 150.76 Mb	Chr 5: 24.42 – 24.42 Mb
PubMed search	[1]	[2]