カルシウムカルモジュリン依存性タンパク質キナーゼ

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Calcium/calmodulin dependent protein kinase II association domain
	CaMKII自己会合ドメインの結晶構造。2M6Iによる。
Identifiers
Symbol	CaMKII_AD
Pfam	PF08332
InterPro	IPR013543
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

英：Ca²⁺/calmodulin-dependent protein kinase、英略語：CaMK 同義語：カルシウムカルモジュリン依存性蛋白質リン酸化酵素、CaMキナーゼ、Ca²⁺／カルモジュリン依存性タンパク質キナーゼ

タンパク質リン酸化酵素は、特定の基質を標的とする”dedicated kinase”と、幅広い基質選択性を有した、”multifunctional kinase”に分類される。Ca2+/カルモジュリンの結合によって活性化されるカルシウムカルモジュリン依存性蛋白質キナーゼも、前者であるMLCK、EF-2キナーゼなどと、後者の多機能性CaMKであるCaMKI、CaMKII、CaMKIVに分類される。多機能性CaMKは、その幅広い基質選択性により、複数の基質を細胞内でリン酸化することが可能と考えられ、その結果様々な細胞種において多彩な細胞機能修飾能を発揮できる。 ^[1]

歴史

1968年に骨格筋においてcAMPによるグリコーゲンの分解がタンパク質リン酸化により媒介されることが発見され、cAMPやcGMP、Ca²⁺といったセカンドメッセンジャーが細胞機能に及ぼす影響の多くが、タンパク質リン酸化により媒介されると考えられるようになりった^[3]。タンパク質リン酸化のCa²⁺による活性化がまず報告されたのは、ホスホリラーゼキナーゼやミオシン軽鎖キナーゼである。脳研究では、シナプトソーム膜（synaptosomal membrane) のCa²⁺依存的なリン酸化が報告されたのち、脳に存在する基質としてsynapsinIなどを基質として用いた酵素精製が進み、CaMKIとCaMKIIが同定され、特に脳において活性が高いことが示された。においても例外ではなく、サイクリックヌクレオチド依存性タンパク質キナーゼの研究が先に進み、ととも1970

分類

構造と活性制御

神経系における多機能性CaMKの発現と機能

CaMKII

CaMKVI

CaMKI

参考文献

↑ Soderling, T.R., & Stull, J.T. (2001).
Structure and regulation of calcium/calmodulin-dependent protein kinases. Chemical reviews, 101(8), 2341-52. [PubMed:11749376] [WorldCat]
↑ Mowrey, D.D., Cui, T., Jia, Y., Ma, D., Makhov, A.M., Zhang, P., ..., & Xu, Y. (2013).
Open-channel structures of the human glycine receptor α1 full-length transmembrane domain. Structure (London, England : 1993), 21(10), 1897-904. [PubMed:23994010] [PMC] [WorldCat] [DOI]
↑ Charbonneau, A.M., Kinsella, J.M., & Tran, S.D. (2019).
3D Cultures of Salivary Gland Cells in Native or Gelled Egg Yolk Plasma, Combined with Egg White and 3D-Printing of Gelled Egg Yolk Plasma. Materials (Basel, Switzerland), 12(21). [PubMed:31652954] [WorldCat] [DOI]
Verigos, J., Karakaidos, P., Kordias, D., Papoudou-Bai, A., Evangelou, Z., Harissis, H.V., ..., & Magklara, A. (2019).
The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program. Cancers, 11(10). [PubMed:31627418] [WorldCat] [DOI]
Aydin, A., Kaçmaz, M., & Boyaci, A. (2019).
Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery. Current therapeutic research, clinical and experimental, 91, 17-21. [PubMed:31384338] [PMC] [WorldCat] [DOI]
Davies, G., Lam, M., Harris, S.E., Trampush, J.W., Luciano, M., Hill, W.D., ..., & Deary, I.J. (2019).
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature communications, 10(1), 2068. [PubMed:31043617] [PMC] [WorldCat] [DOI]
Pan, X., Xiong, K., Anthon, C., Hyttel, P., Freude, K.K., Jensen, L.J., & Gorodkin, J. (2018).
WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA. Genes, 9(11). [PubMed:30404245] [PMC] [WorldCat] [DOI]
Awais, M., Husen, Y., & Rehman, A. (2018).
A Molar Tooth Brainstem With A Bat-Wing Fourth Ventricle: Joubert Syndrome. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 313-314. [PubMed:29938446] [WorldCat]
Furrukh, M., & Qureshi, A. (2018).
Treatment Of Breast Cancer; Review And Updates. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 264-274. [PubMed:29938432] [WorldCat]
AlKindi, M., Ramalingam, S., Abuhaimed, A., & Alkharan, H. (2018).
Undergraduate Implant Dentistry Training In Saudi Dental Schools. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 217-222. [PubMed:29938422] [WorldCat]
Davies, G., Lam, M., Harris, S.E., Trampush, J.W., Luciano, M., Hill, W.D., ..., & Deary, I.J. (2018).
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature communications, 9(1), 2098. [PubMed:29844566] [PMC] [WorldCat] [DOI]
Robinson-Lane, S.G., & Booker, S.Q. (2017).
Culturally Responsive Pain Management for Black Older Adults. Journal of gerontological nursing, 1-8. [PubMed:28253407] [PMC] [WorldCat] [DOI]
Janssen, C.P., & Brumby, D.P. (2010).
Strategic adaptation to performance objectives in a dual-task setting. Cognitive science, 34(8), 1548-60. [PubMed:21564260] [WorldCat] [DOI]
Meshcheryakov, D., Böhmer, V., Bolte, M., Hubscher-Bruder, V., & Arnaud-Neu, F. (2009).
Macrocyclic hexaureas: synthesis, conformation, and anion binding. Chemistry (Weinheim an der Bergstrasse, Germany), 15(19), 4811-21. [PubMed:19296486] [WorldCat] [DOI]
Meshcheryakov, D., Arnaud-Neu, F., Böhmer, V., Bolte, M., Hubscher-Bruder, V., Jobin, E., ..., & Werner, S. (2008).
Cyclic triureas--synthesis, crystal structures and properties. Organic & biomolecular chemistry, 6(6), 1004-14. [PubMed:18327325] [WorldCat] [DOI]
Rodríguez Criado, G., Galán Gómez, E., Tizzano, E.F., García Rodríguez, E., & Gómez de Terreros, I. (2007).
First report of a patient with a mixoploidy 47,XXX/94,XXXXXX. Genetic counseling (Geneva, Switzerland), 18(1), 99-104. [PubMed:17515305] [WorldCat]
Choi, J.Y., Lee, S.H., Park, C.Y., Heo, W.D., Kim, J.C., Kim, M.C., ..., & Cho, M.J. (2002).
Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. The Journal of biological chemistry, 277(24), 21630-8. [PubMed:11901148] [WorldCat] [DOI]

[1] Soderling, T.R., & Stull, J.T. (2001).
Structure and regulation of calcium/calmodulin-dependent protein kinases. Chemical reviews, 101(8), 2341-52. [PubMed:11749376] [WorldCat]

[2] Mowrey, D.D., Cui, T., Jia, Y., Ma, D., Makhov, A.M., Zhang, P., ..., & Xu, Y. (2013).
Open-channel structures of the human glycine receptor α1 full-length transmembrane domain. Structure (London, England : 1993), 21(10), 1897-904. [PubMed:23994010] [PMC] [WorldCat] [DOI]

[3] Charbonneau, A.M., Kinsella, J.M., & Tran, S.D. (2019).
3D Cultures of Salivary Gland Cells in Native or Gelled Egg Yolk Plasma, Combined with Egg White and 3D-Printing of Gelled Egg Yolk Plasma. Materials (Basel, Switzerland), 12(21). [PubMed:31652954] [WorldCat] [DOI]
Verigos, J., Karakaidos, P., Kordias, D., Papoudou-Bai, A., Evangelou, Z., Harissis, H.V., ..., & Magklara, A. (2019).
The Histone Demethylase LSD1/ΚDM1A Mediates Chemoresistance in Breast Cancer via Regulation of a Stem Cell Program. Cancers, 11(10). [PubMed:31627418] [WorldCat] [DOI]
Aydin, A., Kaçmaz, M., & Boyaci, A. (2019).
Comparison of ondansetron, tropisetron, and palonosetron for the prevention of postoperative nausea and vomiting after middle ear surgery. Current therapeutic research, clinical and experimental, 91, 17-21. [PubMed:31384338] [PMC] [WorldCat] [DOI]
Davies, G., Lam, M., Harris, S.E., Trampush, J.W., Luciano, M., Hill, W.D., ..., & Deary, I.J. (2019).
Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature communications, 10(1), 2068. [PubMed:31043617] [PMC] [WorldCat] [DOI]
Pan, X., Xiong, K., Anthon, C., Hyttel, P., Freude, K.K., Jensen, L.J., & Gorodkin, J. (2018).
WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA. Genes, 9(11). [PubMed:30404245] [PMC] [WorldCat] [DOI]
Awais, M., Husen, Y., & Rehman, A. (2018).
A Molar Tooth Brainstem With A Bat-Wing Fourth Ventricle: Joubert Syndrome. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 313-314. [PubMed:29938446] [WorldCat]
Furrukh, M., & Qureshi, A. (2018).
Treatment Of Breast Cancer; Review And Updates. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 264-274. [PubMed:29938432] [WorldCat]
AlKindi, M., Ramalingam, S., Abuhaimed, A., & Alkharan, H. (2018).
Undergraduate Implant Dentistry Training In Saudi Dental Schools. Journal of Ayub Medical College, Abbottabad : JAMC, 30(2), 217-222. [PubMed:29938422] [WorldCat]
Davies, G., Lam, M., Harris, S.E., Trampush, J.W., Luciano, M., Hill, W.D., ..., & Deary, I.J. (2018).
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature communications, 9(1), 2098. [PubMed:29844566] [PMC] [WorldCat] [DOI]
Robinson-Lane, S.G., & Booker, S.Q. (2017).
Culturally Responsive Pain Management for Black Older Adults. Journal of gerontological nursing, 1-8. [PubMed:28253407] [PMC] [WorldCat] [DOI]
Janssen, C.P., & Brumby, D.P. (2010).
Strategic adaptation to performance objectives in a dual-task setting. Cognitive science, 34(8), 1548-60. [PubMed:21564260] [WorldCat] [DOI]
Meshcheryakov, D., Böhmer, V., Bolte, M., Hubscher-Bruder, V., & Arnaud-Neu, F. (2009).
Macrocyclic hexaureas: synthesis, conformation, and anion binding. Chemistry (Weinheim an der Bergstrasse, Germany), 15(19), 4811-21. [PubMed:19296486] [WorldCat] [DOI]
Meshcheryakov, D., Arnaud-Neu, F., Böhmer, V., Bolte, M., Hubscher-Bruder, V., Jobin, E., ..., & Werner, S. (2008).
Cyclic triureas--synthesis, crystal structures and properties. Organic & biomolecular chemistry, 6(6), 1004-14. [PubMed:18327325] [WorldCat] [DOI]
Rodríguez Criado, G., Galán Gómez, E., Tizzano, E.F., García Rodríguez, E., & Gómez de Terreros, I. (2007).
First report of a patient with a mixoploidy 47,XXX/94,XXXXXX. Genetic counseling (Geneva, Switzerland), 18(1), 99-104. [PubMed:17515305] [WorldCat]
Choi, J.Y., Lee, S.H., Park, C.Y., Heo, W.D., Kim, J.C., Kim, M.C., ..., & Cho, M.J. (2002).
Identification of calmodulin isoform-specific binding peptides from a phage-displayed random 22-mer peptide library. The Journal of biological chemistry, 277(24), 21630-8. [PubMed:11901148] [WorldCat] [DOI]

[1]

[2]

[3]