テンプレート:PBB/5649

Reelin
	Crystallographic structure of the third reelin repeat domain based on PDB 2ddu.
Available structures
PDB	2ddu, 2e26
Identifiers
Symbols	RELN; LIS2; PRO1598; RL
External IDs	OMIM: 600514 MGI: 103022 HomoloGene: 3699 GeneCards: RELN Gene
EC number	3.4.21.-
Gene Ontology
Molecular function	• protein serine/threonine/tyrosine kinase activity; • serine-type peptidase activity; • metal ion binding; • lipoprotein particle receptor binding; • very-low-density lipoprotein particle receptor binding;
Cellular component	• proteinaceous extracellular matrix; • extracellular space; • cytoplasm; • dendrite;
Biological process	• cell morphogenesis involved in differentiation; • neuron migration; • proteolysis; • cell adhesion; • axon guidance; • central nervous system development; • brain development; • long-term memory; • associative learning; • glial cell differentiation; • positive regulation of neuron projection development; • positive regulation of phosphatidylinositol 3-kinase cascade; • dendrite development; • peptidyl-tyrosine phosphorylation; • spinal cord patterning; • ventral spinal cord development; • hippocampus development; • cerebral cortex tangential migration; • positive regulation of TOR signaling cascade; • positive regulation of CREB transcription factor activity; • reelin-mediated signaling pathway; • positive regulation of protein kinase activity; • response to pain; • positive regulation of peptidyl-tyrosine phosphorylation; • regulation of behavior; • regulation of synaptic transmission; • positive regulation of small GTPase mediated signal transduction; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of dendritic spine morphogenesis; • positive regulation of protein tyrosine kinase activity; • positive regulation of synapse maturation; • N-methyl-D-aspartate receptor clustering; • postsynaptic density protein 95 clustering; • receptor localization to synapse; • positive regulation of long-term synaptic potentiation; • regulation of N-methyl-D-aspartate selective glutamate receptor activity; • positive regulation of excitatory postsynaptic membrane potential; • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

References

↑ Nogi, T., Yasui, N., Hattori, M., Iwasaki, K., & Takagi, J. (2006).
Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. The EMBO journal, 25(15), 3675-83. [PubMed:16858396] [PMC] [WorldCat] [DOI]

[1] Nogi, T., Yasui, N., Hattori, M., Iwasaki, K., & Takagi, J. (2006).
Structure of a signaling-competent reelin fragment revealed by X-ray crystallography and electron tomography. The EMBO journal, 25(15), 3675-83. [PubMed:16858396] [PMC] [WorldCat] [DOI]

[1]