Triphenylbromoethylene

Triphenylbromoethylene
ファイル:Triphenylbromoethylene.png
Systematic (IUPAC) name
	(1-bromo-2,2-diphenylethenyl)benzene
Clinical data
Trade names	Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	1607-57-4
ATC code	?
PubChem	CID 15354
ChemSpider	14615
UNII	MRW5MKO6LZ
Synonyms	TPBE; Tribromophenylethylene; Bromotriphenylethylene; Phenylstilbene bromide; Fenbrostilbenum
Chemical data
Formula	C20H15Br
	InChI InChI=1S/C20H15Br/c21-20(18-14-8-3-9-15-18)19(16-10-4-1-5-11-16)17-12-6-2-7-13-17/h1-15H; Key:VUQVJIUBUPPCDB-UHFFFAOYSA-N;

Triphenylbromoethylene (TPBE; brand names Bromylene, Eitriphin, Oestronyl, Prostilban, Tribenorm), also known as bromotriphenylethylene or as phenylstilbene bromide, is a synthetic nonsteroidal estrogen of the triphenylethylene group that was marketed in the 1940s similarly to the closely related estrogen triphenylchloroethylene.^[1]^[2]

A diethoxylated derivative of triphenylbromoethylene, estrobin (DBE), is also an estrogen, but, in contrast, was never marketed.^[3] An ethylated derivative of triphenylbromoethylene, broparestrol (BDPE), is a selective estrogen receptor modulator (SERM) that has been marketed.^[4]^[5]

References

↑ Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 1861. ISBN 978-3-527-30247-5. C20H15Br. 1607-57-4. Bromotriphenylethene = Triphenylbromoethylene = Phenylstilbene bromide = 1,1',1"-(1-Bromo-1-ethenyl-2-yli- dene)tris[benzene] (•) S Bromylene, Fenbrostilbenum, Oestronyl, Phenylstilbene bromide, Prostilban, Tribenorm U Synthetic estrogen
↑ Paterson E, Gilbert CW (May 1949). "Metabolism of the oestrogen triphenylbromoethylene". Nature. 163 (4151): 801–802. Bibcode:1949Natur.163..801P. doi:10.1038/163801a0. PMID 18128458. S2CID 13052481.
↑ Emmens CW (22 October 2013). Hormone Assay. Elsevier Science. pp. 394–. ISBN 978-1-4832-7286-3.
↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 183–. ISBN 978-1-4757-2085-3.
↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 139–. ISBN 978-3-88763-075-1.

テンプレート:Genito-urinary-drug-stub

[NegwerScharnow2001-1] Negwer M, Scharnow HG (2001). Organic-chemical drugs and their synonyms: (an international survey). Wiley-VCH. p. 1861. ISBN 978-3-527-30247-5. C20H15Br. 1607-57-4. Bromotriphenylethene = Triphenylbromoethylene = Phenylstilbene bromide = 1,1',1"-(1-Bromo-1-ethenyl-2-yli- dene)tris[benzene] (•) S Bromylene, Fenbrostilbenum, Oestronyl, Phenylstilbene bromide, Prostilban, Tribenorm U Synthetic estrogen

[PatersonGilbert1949-2] Paterson E, Gilbert CW (May 1949). "Metabolism of the oestrogen triphenylbromoethylene". Nature. 163 (4151): 801–802. Bibcode:1949Natur.163..801P. doi:10.1038/163801a0. PMID 18128458. S2CID 13052481.

[Emmens2013-3] Emmens CW (22 October 2013). Hormone Assay. Elsevier Science. pp. 394–. ISBN 978-1-4832-7286-3.

[Elks2014-4] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 183–. ISBN 978-1-4757-2085-3.

[IndexNominum2000-5] Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 139–. ISBN 978-3-88763-075-1.

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[2]

[3]

[4]

[5]

Triphenylbromoethylene

See also

References