テンプレート:PBB/1950

Epidermal growth factor
	Rainbow colored NMR structure (N-terminus = blue, C-terminus = red) of the mouse epidermal growth factor.
Available structures
PDB	1IVO, 1JL9, 1NQL, 1P9J, 3NJP
Identifiers
Symbols	EGF; HOMG4; URG
External IDs	OMIM: 131530 MGI: 95290 HomoloGene: 1483 GeneCards: EGF Gene
Gene Ontology
Molecular function	• epidermal growth factor receptor binding; • calcium ion binding; • protein binding; • growth factor activity; • transmembrane receptor protein tyrosine kinase activator activity;
Cellular component	• extracellular region; • extracellular region; • extracellular space; • soluble fraction; • plasma membrane; • integral to membrane; • platelet alpha granule lumen;
Biological process	• activation of MAPKK activity; • angiogenesis; • platelet degranulation; • DNA replication; • signal transduction; • activation of transmembrane receptor protein tyrosine kinase activity; • epidermal growth factor receptor signaling pathway; • STAT protein import into nucleus; • blood coagulation; • positive regulation of cell proliferation; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of cerebellar granule cell precursor proliferation; • platelet activation; • positive regulation of catenin import into nucleus; • negative regulation of epidermal growth factor receptor signaling pathway; • positive regulation of phosphorylation; • positive regulation of DNA binding; • positive regulation of MAP kinase activity; • positive regulation of epidermal growth factor-activated receptor activity; • positive regulation of epidermal growth factor-activated receptor activity; • positive regulation of mitosis; • positive regulation of transcription, DNA-dependent; • branching morphogenesis of a tube; • regulation of protein secretion; • regulation of peptidyl-tyrosine phosphorylation; • negative regulation of secretion; • mammary gland alveolus development; • ERK1 and ERK2 cascade; • regulation of calcium ion import; • negative regulation of cholesterol efflux; • regulation of protein localization at cell surface; • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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↑ Barnham, K.J., Torres, A.M., Alewood, D., Alewood, P.F., Domagala, T., Nice, E.C., & Norton, R.S. (1998).
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein science : a publication of the Protein Society, 7(8), 1738-49. [PubMed:10082370] [PMC] [WorldCat] [DOI]

[pmid10082370-1] Barnham, K.J., Torres, A.M., Alewood, D., Alewood, P.F., Domagala, T., Nice, E.C., & Norton, R.S. (1998).
Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. Protein science : a publication of the Protein Society, 7(8), 1738-49. [PubMed:10082370] [PMC] [WorldCat] [DOI]

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