9,444
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細 (→リガンド) |
細 (→リガンド) |
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5行目: | 5行目: | ||
== リガンド == | == リガンド == | ||
{| width="1300" cellspacing="1" cellpadding="1" border="1 | {| width="1300" cellspacing="1" cellpadding="1" border="1" | ||
|- | |- | ||
| | | style="background-color:#d3d3d3; text-align:center" colspan="2" rowspan="2" | サブファミリー | ||
| style="background-color:#d3d3d3; text-align:center" colspan="2" rowspan="2" | グループ | |||
| | | style="background-color:#d3d3d3; text-align:center" colspan="5" | メンバー | ||
|- | |- | ||
| style="background-color:#d3d3d3; text-align:center" | 正式名 | | style="background-color:#d3d3d3; text-align:center" | 正式名 | ||
19行目: | 19行目: | ||
| rowspan="19" | 1 | | rowspan="19" | 1 | ||
| rowspan="19" | Thyroid Hormone Receptor-like | | rowspan="19" | Thyroid Hormone Receptor-like | ||
| rowspan="2" | | rowspan="2" | A | ||
| rowspan="2" | Thyroid hormone receptor | | rowspan="2" | Thyroid hormone receptor | ||
| NR1A1 | | NR1A1 | ||
29行目: | 29行目: | ||
| NR1A2 | | NR1A2 | ||
| TRb | | TRb | ||
| Thyroid hormone receptor- | | Thyroid hormone receptor-beta | ||
| THRB | | THRB | ||
|- | |- | ||
51行目: | 51行目: | ||
|- | |- | ||
| rowspan="3" | C | | rowspan="3" | C | ||
| rowspan="3" | Peroxisome proliferator- | | rowspan="3" | Peroxisome proliferator-activated receptor | ||
| NR1C1 | | NR1C1 | ||
| PPARa | | PPARa | ||
| Peroxisome proliferator- | | Peroxisome proliferator-activated receptor-alpha | ||
| PPARA | | PPARA | ||
| rowspan="3" | 脂肪酸、プロスタグランジン | | rowspan="3" | 脂肪酸、プロスタグランジン | ||
60行目: | 60行目: | ||
| NR1C2 | | NR1C2 | ||
| PPARb/d | | PPARb/d | ||
| Peroxisome proliferator- | | Peroxisome proliferator-activated receptor-alpha | ||
| PPARD | | PPARD | ||
|- | |- | ||
| | | NR1C3 | ||
| | | PPARg | ||
| Peroxisome proliferator- | | Peroxisome proliferator-activated receptor-alpha | ||
| PPARG | | PPARG | ||
|- | |- | ||
73行目: | 73行目: | ||
| Rev-ErbAa | | Rev-ErbAa | ||
| Rev-ErbA-alpha | | Rev-ErbA-alpha | ||
| | | NR1D1 | ||
| rowspan="2" | ヘム | | rowspan="2" | ヘム | ||
|- | |- | ||
79行目: | 79行目: | ||
| Rev-ErbAb | | Rev-ErbAb | ||
| Rev-ErbA-beta | | Rev-ErbA-beta | ||
| | | NR1D2 | ||
|- | |- | ||
| rowspan="3" | F | | rowspan="3" | F | ||
104行目: | 104行目: | ||
| LXRa | | LXRa | ||
| Liver X receptor-alpha | | Liver X receptor-alpha | ||
| NR1H3 | | NR1H3 | ||
| rowspan="3" | oxysteroids | | rowspan="3" | oxysteroids | ||
|- | |- | ||
114行目: | 114行目: | ||
| NR1H4 | | NR1H4 | ||
| FXR | | FXR | ||
| Farnesoid X receptor | | Farnesoid X receptor | ||
| NR1H4 | | NR1H4 | ||
|- | |- | ||
120行目: | 120行目: | ||
| rowspan="3" | Vitamin D receptor-like | | rowspan="3" | Vitamin D receptor-like | ||
| NR1I1 | | NR1I1 | ||
| VDR | | VDR | ||
| Vitamin D receptor | | Vitamin D receptor | ||
| VDR | | VDR | ||
| ビタミンD | | ビタミンD | ||
|- | |- | ||
| NR1I2 | | NR1I2 | ||
| PXR | | PXR | ||
| Pregnane X receptor | | Pregnane X receptor | ||
| NR1I2 | | NR1I2 | ||
| xenobiotics(生体異物) | | xenobiotics(生体異物) | ||
|- | |- | ||
| NR1I3 | | NR1I3 | ||
| CAR | | CAR | ||
| Contitutive androstane receptor | | Contitutive androstane receptor | ||
| NR1I3 | | NR1I3 | ||
| androstane | | androstane | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="12" | 2 | ||
| style="background-color:#d3d3d3" rowspan="12" | Retinoid X Receptor-like | |||
| | | style="background-color:#d3d3d3" rowspan="2" | A | ||
| style="background-color:#d3d3d3" rowspan="2" | Hepatocyte nuclear factor 4 | |||
| style="background-color:#d3d3d3" | NR2A1 | | style="background-color:#d3d3d3" | NR2A1 | ||
| style="background-color:#d3d3d3" | HNF4a | | style="background-color:#d3d3d3" | HNF4a | ||
| style="background-color:#d3d3d3" | Hepatocyte nuclear factor-4-alpha | | style="background-color:#d3d3d3" | Hepatocyte nuclear factor-4-alpha | ||
| style="background-color:#d3d3d3" | HNF4A | | style="background-color:#d3d3d3" | HNF4A | ||
| | | style="background-color:#d3d3d3" rowspan="2" | 脂肪酸 | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2A2 | | style="background-color:#d3d3d3" | NR2A2 | ||
| style="background-color:#d3d3d3" | HNF4g | | style="background-color:#d3d3d3" | HNF4g | ||
| style="background-color:#d3d3d3" | Hepatocyte nuclear factor-4-gamma | | style="background-color:#d3d3d3" | Hepatocyte nuclear factor-4-gamma | ||
| style="background-color:#d3d3d3" | HNF4G | | style="background-color:#d3d3d3" | HNF4G | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="3" | B | ||
| style="background-color:#d3d3d3" rowspan="3" | Retinoid X receptor | |||
| style="background-color:#d3d3d3" | NR2B1 | | style="background-color:#d3d3d3" | NR2B1 | ||
| style="background-color:#d3d3d3" | RXRa | | style="background-color:#d3d3d3" | RXRa | ||
| style="background-color:#d3d3d3" | Retinoid X receptor-alpha | | style="background-color:#d3d3d3" | Retinoid X receptor-alpha | ||
| style="background-color:#d3d3d3" | RXRA | | style="background-color:#d3d3d3" | RXRA | ||
| | | style="background-color:#d3d3d3" rowspan="3" | レチノイド | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2B2 | | style="background-color:#d3d3d3" | NR2B2 | ||
| style="background-color:#d3d3d3" | RXRb | | style="background-color:#d3d3d3" | RXRb | ||
| style="background-color:#d3d3d3" | Retinoid X receptor-beta | | style="background-color:#d3d3d3" | Retinoid X receptor-beta | ||
| style="background-color:#d3d3d3" | RXRB | | style="background-color:#d3d3d3" | RXRB | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2B3 | | style="background-color:#d3d3d3" | NR2B3 | ||
| style="background-color:#d3d3d3" | RXRg | | style="background-color:#d3d3d3" | RXRg | ||
| style="background-color:#d3d3d3" | Retinoid X receptor-gamma | | style="background-color:#d3d3d3" | Retinoid X receptor-gamma | ||
| style="background-color:#d3d3d3" | RXRG | | style="background-color:#d3d3d3" | RXRG | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="2" | C | ||
| style="background-color:#d3d3d3" rowspan="2" | Testicular receptor | |||
| style="background-color:#d3d3d3" | NR2C1 | | style="background-color:#d3d3d3" | NR2C1 | ||
| style="background-color:#d3d3d3" | TR2 | | style="background-color:#d3d3d3" | TR2 | ||
| style="background-color:#d3d3d3" | Testicular receptor 2 | | style="background-color:#d3d3d3" | Testicular receptor 2 | ||
| style="background-color:#d3d3d3" | NR2C1 | | style="background-color:#d3d3d3" | NR2C1 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2C2 | | style="background-color:#d3d3d3" | NR2C2 | ||
182行目: | 182行目: | ||
| style="background-color:#d3d3d3" | Testicular receptor 4 | | style="background-color:#d3d3d3" | Testicular receptor 4 | ||
| style="background-color:#d3d3d3" | NR2C2 | | style="background-color:#d3d3d3" | NR2C2 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="2" | E | ||
| style="background-color:#d3d3d3" rowspan="2" | TLX/PNR | |||
| style="background-color:#d3d3d3" | NR2E1 | | style="background-color:#d3d3d3" | NR2E1 | ||
| style="background-color:#d3d3d3" | TLX | | style="background-color:#d3d3d3" | TLX | ||
| style="background-color:#d3d3d3" | Homologue of the | | style="background-color:#d3d3d3" | Homologue of the Drosophila tailless gene | ||
| style="background-color:#d3d3d3" | NR2E1 | | style="background-color:#d3d3d3" | NR2E1 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2E3 | | style="background-color:#d3d3d3" | NR2E3 | ||
196行目: | 196行目: | ||
| style="background-color:#d3d3d3" | Photoreceptor cell-specific nuclear receptor | | style="background-color:#d3d3d3" | Photoreceptor cell-specific nuclear receptor | ||
| style="background-color:#d3d3d3" | NR2E3 | | style="background-color:#d3d3d3" | NR2E3 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="3" | F | ||
| style="background-color:#d3d3d3" rowspan="3" | COUP/EAR | |||
| style="background-color:#d3d3d3" | NR2F1 | | style="background-color:#d3d3d3" | NR2F1 | ||
| style="background-color:#d3d3d3" | COUP-TFI | | style="background-color:#d3d3d3" | COUP-TFI | ||
| style="background-color:#d3d3d3" | Chicken ovalbumin upstream promoter-transcription factor I | | style="background-color:#d3d3d3" | Chicken ovalbumin upstream promoter-transcription factor I | ||
| style="background-color:#d3d3d3" | NR2F1 | | style="background-color:#d3d3d3" | NR2F1 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2F2 | | style="background-color:#d3d3d3" | NR2F2 | ||
| style="background-color:#d3d3d3" | COUP-TFII | | style="background-color:#d3d3d3" | COUP-TFII | ||
| style="background-color:#d3d3d3" | Chicken ovalbumin upstream promoter-transcription factor II | | style="background-color:#d3d3d3" | Chicken ovalbumin upstream promoter-transcription factor II | ||
| style="background-color:#d3d3d3" | NR2F2 | | style="background-color:#d3d3d3" | NR2F2 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR2F6 | | style="background-color:#d3d3d3" | NR2F6 | ||
| style="background-color:#d3d3d3" | EAR-2, COUP-TFIII | | style="background-color:#d3d3d3" | EAR-2, COUP-TFIII | ||
| style="background-color:#d3d3d3" | V-erbA-related | | style="background-color:#d3d3d3" | V-erbA-related | ||
| style="background-color:#d3d3d3" | NR2F6 | | style="background-color:#d3d3d3" | NR2F6 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| rowspan="9" | 3 | | rowspan="9" | 3 | ||
| rowspan="9" | Estrogen Receptor-like | | rowspan="9" | Estrogen Receptor-like | ||
| rowspan="2" | | rowspan="2" | A | ||
| rowspan="2" | Estrogen receptor | | rowspan="2" | Estrogen receptor | ||
| NR3A1 | | NR3A1 | ||
231行目: | 231行目: | ||
| ERb | | ERb | ||
| Estrogen receptor-beta | | Estrogen receptor-beta | ||
| ESR2 | | ESR2 | ||
|- | |- | ||
| rowspan="3" | | rowspan="3" | B | ||
| rowspan="3" | Estrogen related receptor | | rowspan="3" | Estrogen related receptor | ||
| NR3B1 | | NR3B1 | ||
251行目: | 251行目: | ||
| Estrogen related receptor-gamma | | Estrogen related receptor-gamma | ||
| ESRRG | | ESRRG | ||
| | | | ||
|- | |- | ||
| rowspan="4" | | rowspan="4" | C | ||
| rowspan="4" | 3-Ketosteroid receptor | | rowspan="4" | 3-Ketosteroid receptor | ||
| NR3C1 | | NR3C1 | ||
265行目: | 265行目: | ||
| Mineralocorticoid receptor | | Mineralocorticoid receptor | ||
| NR3C2 | | NR3C2 | ||
| アルドステロン | | アルドステロン | ||
|- | |- | ||
| NR3C3 | | NR3C3 | ||
271行目: | 271行目: | ||
| Progesterone receptor | | Progesterone receptor | ||
| PGR | | PGR | ||
| プロゲステロン | | プロゲステロン | ||
|- | |- | ||
| NR3C4 | | NR3C4 | ||
277行目: | 277行目: | ||
| Androgen receptor | | Androgen receptor | ||
| AR | | AR | ||
| テストステロン | | テストステロン | ||
|- | |- | ||
| | | style="background-color:#d3d3d3" rowspan="3" | 4 | ||
| style="background-color:#d3d3d3" rowspan="3" | Nerve Growth Factor IB-like | |||
| | | style="background-color:#d3d3d3" rowspan="3" | A | ||
| style="background-color:#d3d3d3" rowspan="3" | NGFIB/NURR1/NOR1 | |||
| style="background-color:#d3d3d3" | NR4A1 | | style="background-color:#d3d3d3" | NR4A1 | ||
| style="background-color:#d3d3d3" | NGFIB | | style="background-color:#d3d3d3" | NGFIB | ||
| style="background-color:#d3d3d3" | Nerve Growth Factor IB | | style="background-color:#d3d3d3" | Nerve Growth Factor IB | ||
| style="background-color:#d3d3d3" | NR4A1 | | style="background-color:#d3d3d3" | NR4A1 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR4A2 | | style="background-color:#d3d3d3" | NR4A2 | ||
293行目: | 293行目: | ||
| style="background-color:#d3d3d3" | Nuclear receptor related 1 | | style="background-color:#d3d3d3" | Nuclear receptor related 1 | ||
| style="background-color:#d3d3d3" | NR4A2 | | style="background-color:#d3d3d3" | NR4A2 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| style="background-color:#d3d3d3" | NR4A3 | | style="background-color:#d3d3d3" | NR4A3 | ||
303行目: | 303行目: | ||
| rowspan="2" | 5 | | rowspan="2" | 5 | ||
| rowspan="2" | Steroidogenic Factor-like | | rowspan="2" | Steroidogenic Factor-like | ||
| rowspan="2" | | rowspan="2" | A | ||
| rowspan="2" | SF1/LRH1 | | rowspan="2" | SF1/LRH1 | ||
| NR5A1 | | NR5A1 | ||
314行目: | 314行目: | ||
| LRH1 | | LRH1 | ||
| Liver receptor homolog-1 | | Liver receptor homolog-1 | ||
| NR5A2 | | NR5A2 | ||
|- | |- | ||
| style="background-color:#d3d3d3" | 6 | | style="background-color:#d3d3d3" | 6 | ||
324行目: | 324行目: | ||
| style="background-color:#d3d3d3" | Germ cell nuclear factor | | style="background-color:#d3d3d3" | Germ cell nuclear factor | ||
| style="background-color:#d3d3d3" | NR6A1 | | style="background-color:#d3d3d3" | NR6A1 | ||
| style="background-color:#d3d3d3" | | | style="background-color:#d3d3d3" | | ||
|- | |- | ||
| rowspan="2" | 0 | | rowspan="2" | 0 | ||
| rowspan="2" | Miscellaneous | | rowspan="2" | Miscellaneous | ||
| rowspan="2" | | rowspan="2" | B | ||
| rowspan="2" | DAX/SHP | | rowspan="2" | DAX/SHP | ||
| NR0B1 | | NR0B1 | ||
342行目: | 342行目: | ||
| | | | ||
|} | |} | ||
'''表1. ヒト核内受容体ファミリー'''<ref name="ref3"><pubmed>18023286</pubmed></ref> | |||
リガンドからNRを分類すると、(1)ホルモンやビタミンをリガンドとする内分泌受容体、(2)配列相同性から発見され、後に生体内でのリガンドが同定されたもの、(3)リガンドの生体での機能が明らかでないもの、(4)リガンドの同定されていないものがある。 | リガンドからNRを分類すると、(1)ホルモンやビタミンをリガンドとする内分泌受容体、(2)配列相同性から発見され、後に生体内でのリガンドが同定されたもの、(3)リガンドの生体での機能が明らかでないもの、(4)リガンドの同定されていないものがある。 |