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チロシンリン酸化 (ソースを閲覧)

2012年1月5日 (木) 23:01時点における版

5,001 バイト追加 、 2012年1月5日 (木)
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==チロシンリン酸化酵素  ==
==チロシンリン酸化酵素  ==
{{Pfam_box
| Symbol = SH2
| Name =
| image = 1lkkA_SH2_domain.png
| width = 220
| caption = Crystallographic structure of the SH2 domain. The structure consists of a large [[beta sheet]] (green) flanked by two [[alpha helix|alpha-helices]] (orange and blue).<ref name="pmid8604142">{{PDB|1lkk}}; {{cite journal | author = Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S | title = Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution | journal = J. Mol. Biol. | volume = 256 | issue = 3 | pages = 601–10 | year = 1996 | month = March | pmid = 8604142 | doi = 10.1006/jmbi.1996.0112 | url = | issn = }}</ref>
| Pfam= PF00017
| InterPro= IPR000980
| SMART= SH2
| PROSITE=PDOC50001
| SCOP = 1sha
| TCDB =
| OPM family=
| OPM protein= 1xa6
| CDD = cd00173
| PDB=
{{PDB3|1k9a}}B:82-156    {{PDB3|1jwo}}A:122-196  {{PDB3|1a81}}G:168-244
{{PDB3|1csz}}A:168-244  {{PDB3|1csy}}A:168-244  {{PDB3|1m61}}A:163-239
{{PDB3|1nrv}}B:493-574  {{PDB3|1mw4}}A:431-512  {{PDB3|2aug}}A:439-520
{{PDB3|2shp}}A:112-197  {{PDB3|1x6c}}A:110-194  {{PDB3|2b3o}}A:110-194
{{PDB3|1ayc}}A:6-81      {{PDB3|1aya}}B:6-81      {{PDB3|1ayb}}A:6-81
{{PDB3|1ayd}} :6-81      {{PDB3|1ju5}}A:13-104    {{PDB3|1sps}}A:148-230
{{PDB3|1spr}}C:148-230  {{PDB3|1bkl}} :148-230  {{PDB3|1bkm}} :148-230
{{PDB3|1kc2}}A:148-230  {{PDB3|1is0}}A:148-230  {{PDB3|1nzv}}A:148-230
{{PDB3|1nzl}}A:148-230  {{PDB3|1skj}} :148-230  {{PDB3|1shb}}A:148-230
{{PDB3|1sha}}A:148-230  {{PDB3|1p13}}B:148-230  {{PDB3|2ptk}}A:148-230
{{PDB3|1f1w}}A:148-230  {{PDB3|1f2f}}A:148-230  {{PDB3|1o4k}}A:151-233
{{PDB3|1o4i}}A:151-233  {{PDB3|1o4h}}A:151-233  {{PDB3|1a09}}B:151-233
{{PDB3|1o46}}A:151-233  {{PDB3|1o43}}A:151-233  {{PDB3|1o4d}}A:151-233
{{PDB3|1o4b}}A:151-233  {{PDB3|1ksw}}A:151-233  {{PDB3|1a1b}}B:151-233
{{PDB3|1a1e}}B:151-233  {{PDB3|1o4j}}A:151-233  {{PDB3|1o4m}}A:151-233
{{PDB3|1o4c}}A:151-233  {{PDB3|1a08}}A:151-233  {{PDB3|1a07}}B:151-233
{{PDB3|1o49}}A:151-233  {{PDB3|1fmk}} :151-233  {{PDB3|1o4n}}A:151-233
{{PDB3|1hcs}}B:151-233  {{PDB3|2src}} :151-233  {{PDB3|1a1a}}B:151-233
{{PDB3|1a1c}}A:151-233  {{PDB3|1o4f}}A:151-233  {{PDB3|1o4e}}A:151-233
{{PDB3|1o4q}}A:151-233  {{PDB3|1o4r}}A:151-233  {{PDB3|1o48}}A:151-233
{{PDB3|1shd}}A:151-233  {{PDB3|1y57}}A:151-233  {{PDB3|1hct}}B:151-233
{{PDB3|1o45}}A:151-233  {{PDB3|1o4g}}A:151-233  {{PDB3|1o4o}}A:151-233
{{PDB3|1o47}}A:151-233  {{PDB3|1o42}}A:151-233  {{PDB3|1o44}}A:151-233
{{PDB3|1o4a}}A:151-233  {{PDB3|1o41}}A:151-233  {{PDB3|1o4p}}A:151-233
{{PDB3|1o4l}}A:151-233  {{PDB3|1g83}}A:149-231  {{PDB3|1aot}}F:149-231
{{PDB3|1aou}}F:149-231  {{PDB3|1lkk}}A:127-209  {{PDB3|1ijr}}A:127-209
{{PDB3|1fbz}}B:127-209  {{PDB3|1cwe}}A:127-209  {{PDB3|1lcj}}A:127-209
{{PDB3|1cwd}}L:127-209  {{PDB3|1lck}}A:127-209  {{PDB3|1bhf}}A:127-209
{{PDB3|1lkl}}A:127-209  {{PDB3|1qcf}}A:144-226  {{PDB3|1ad5}}A:144-226
{{PDB3|2hck}}B:144-226  {{PDB3|3hck}} :144-226  {{PDB3|1blj}} :118-199
{{PDB3|1blk}} :118-199  {{PDB3|1pic}}A:624-698  {{PDB3|1h9o}}A:624-698
{{PDB3|1bfj}} :624-698  {{PDB3|1bfi}} :624-698  {{PDB3|1qad}}A:624-698
{{PDB3|1z3k}}A:285-359  {{PDB3|1fhs}} :60-135    {{PDB3|1cj1}}A:60-135
{{PDB3|1fyr}}A:60-135    {{PDB3|2aob}}C:60-135    {{PDB3|1bm2}}A:60-135
{{PDB3|1bmb}}A:60-135    {{PDB3|1gri}}A:60-135    {{PDB3|1x0n}}A:60-135
{{PDB3|1jyu}}A:60-135    {{PDB3|1qg1}}E:60-135    {{PDB3|2aoa}}B:60-135
{{PDB3|1jyq}}B:60-135    {{PDB3|1zfp}}E:60-135    {{PDB3|1jyr}}A:60-135
{{PDB3|1ghu}} :60-135    {{PDB3|1r1q}}B:58-132    {{PDB3|1r1s}}A:58-132
{{PDB3|1r1p}}D:58-132    {{PDB3|1wcp}}A:488-559  {{PDB3|1mil}} :488-559
{{PDB3|1opk}}A:127-202  {{PDB3|2abl}} :127-202  {{PDB3|1opl}}A:127-202
{{PDB3|1ab2}} :127-202  {{PDB3|1ka6}}A:7-87      {{PDB3|1d4w}}A:7-87
{{PDB3|1d1z}}A:7-87      {{PDB3|1m27}}A:7-87      {{PDB3|1d4t}}A:7-87
{{PDB3|1ka7}}A:7-87      {{PDB3|1i3z}}A:5-86      {{PDB3|2cs0}}A:34-109
{{PDB3|2fci}}A:668-741  {{PDB3|2ple}}A:668-741  {{PDB3|2pld}}A:668-741
{{PDB3|1wqu}}A:460-530  {{PDB3|1rqq}}C:409-486  {{PDB3|1rpy}}A:409-486
{{PDB3|2crh}}A:671-745  {{PDB3|1xa6}}A:59-130    {{PDB3|2pna}} :333-408
{{PDB3|2pnb}} :333-408  {{PDB3|1oo4}}A:333-408  {{PDB3|1oo3}}A:333-408
{{PDB3|1fu5}}A:333-408  {{PDB3|1fu6}}A:333-408  {{PDB3|1lui}}A:245-328
{{PDB3|1luk}}A:245-328  {{PDB3|1lum}}A:245-328  {{PDB3|1lun}}A:245-328
{{PDB3|1yvl}}A:573-668  {{PDB3|1bf5}}A:573-668  {{PDB3|1bg1}}A:584-674
{{PDB3|1y1u}}A:589-670  {{PDB3|1uur}}A:587-658  {{PDB3|1uus}}A:587-658
}}
{{Pfam box
| Symbol = SH3_1
| Name = SH3 domain
| image =1shg SH3 domain.png
| width =200
| caption =Ribbon diagram of the SH3 domain, alpha spectrin, from [[chicken]] (PDB accession code 1SHG), colored from blue (N-terminus) to red (C-terminus).
| Pfam= PF00018
| Pfam_clan= CL0010
| InterPro= IPR001452
| SMART=  SM00326
| PROSITE = PS50002
| SuperFamily = SSF50044
| SCOP = 1shf
| TCDB =
| CDD = cd00174
| OPM family=
| OPM protein=
| PDB=
}}
　1979年Tony Hunterにより、[[wikipedia:ja:癌遺伝子|癌遺伝子]]産物[[wikipedia:V-Src|V-Src]]および[[wikipedia:ja:癌遺伝子|癌原遺伝子]]産物[[wikipedia:C-src tyrosine kinase|C-Src]]がチロシンリン酸化活性を持つことが発見された<ref><pubmed>19269802</pubmed></ref>。これが最初のチロシンキナーゼの報告例であり、以後、多くのチロシンキナーゼが同定された。
　1979年Tony Hunterにより、[[wikipedia:ja:癌遺伝子|癌遺伝子]]産物[[wikipedia:V-Src|V-Src]]および[[wikipedia:ja:癌遺伝子|癌原遺伝子]]産物[[wikipedia:C-src tyrosine kinase|C-Src]]がチロシンリン酸化活性を持つことが発見された<ref><pubmed>19269802</pubmed></ref>。これが最初のチロシンキナーゼの報告例であり、以後、多くのチロシンキナーゼが同定された。


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