|
|
(3人の利用者による、間の146版が非表示) |
1行目: |
1行目: |
| {| cellspacing="1" cellpadding="1" border="1" style="width: 619px; height: 1446px;"
| | [[File:Nozaki dysphasia movie1.mp4|500px|thumb|'''動画1''']] |
| |+ 表1 主なS-パルミトイル化タンパク質<br>
| | [[File:Nozaki dysphasia movie2.mp4|500px|thumb|'''動画2''']] |
| {| cellspacing="1" cellpadding="1" border="1" style="width: 689px; height: 451px;"
| | [[File:Nozaki dysphasia movie3.mp4|500px|thumb|'''動画3''']] |
| |-
| | [[File:Nozaki dysphasia movie4.mp4|500px|thumb|'''動画4''']] |
| | ファミリー<br>
| |
| | 主な例<br> | |
| |- | |
| | '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br> | |
| | <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br> | |
| |- | |
| | | |
| '''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br> | |
| | |
| | GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR
| |
| |-
| |
| | '''Adaptor, Scaffold'''<br> | |
| | PSD95, PSD93α/β, GRIP1/2, Delphilin<br> | |
| |-
| |
| | '''Viral protein'''<br> | |
| | Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br>
| |
| |-
| |
| | '''N-palmitoylated protein'''<br>
| |
| | Sonic Hedgehog, Wnt, Ghrelin <br>
| |
| |}
| |
| | |
| <br>
| |
| | |
| <br>
| |
| | |
| 表2 パルミチルトランスフェラーゼ
| |
| | |
| | |
| | |
| |-
| |
| ! scope="col" | 酵素
| |
| ! scope="col" | 別名
| |
| ! scope="col" | 主な基質
| |
| ! scope="col" | 局在(過剰発現系)
| |
| ! scope="col" | 関連疾患
| |
| |-
| |
| | DHHC1
| |
| | ZDHHC1
| |
| | <br>
| |
| | ER
| |
| | <br>
| |
| |-
| |
| | DHHC2
| |
| | ZDHHC2
| |
| | PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br>
| |
| | ER/ゴルジ体<br>
| |
| | 癌<br>
| |
| |-
| |
| | DHHC3<br>
| |
| |
| |
| ZDHHC3
| |
| | |
| GODZ<br>
| |
| | |
| | PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br>
| |
| | ゴルジ体<br>
| |
| | <br> | |
| |- | |
| | DHHC4<br> | |
| | ZDHHC4<br>
| |
| | BACE1<br>
| |
| | ゴルジ体<br>
| |
| | <br>
| |
| |-
| |
| | DHHC5<br>
| |
| | ZDHHC5<br>
| |
| | STREX<br>
| |
| | <br>
| |
| | <br>
| |
| |-
| |
| | DHHC6<br>
| |
| | ZDHHC6<br>
| |
| | <br>
| |
| | <br>
| |
| | <br>
| |
| |-
| |
| | DHHC7<br>
| |
| | ZDHHC7<br>
| |
| | PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br>
| |
| | ゴルジ体<br>
| |
| | <br>
| |
| |-
| |
| | DHHC8<br>
| |
| | ZDHHC8<br>
| |
| | PSD95, SNAP25, eNOS, paralemmin-1<br>
| |
| | ゴルジ体<br>
| |
| | 統合失調症<br>
| |
| |-
| |
| | DHHC9'''<br>'''
| |
| | ZDHHC9<br>
| |
| | H-RAS, N-Ras<br>
| |
| | ER/ゴルジ体<br>
| |
| | 癌、X連鎖神経遅滞<br>
| |
| |-
| |
| | DHHC10<br>
| |
| | ZDHHC11<br>
| |
| | <br>
| |
| | ER<br>
| |
| | <br>
| |
| |-
| |
| | DHHC11<br>
| |
| | ZDHHC23<br>NIDD<br>
| |
| | <br>
| |
| | ER<br>
| |
| | 癌<br>
| |
| |-
| |
| | DHHC12<br>
| |
| | ZDHHC12<br>
| |
| | ABC transporter A1<br>
| |
| | ER/ゴルジ体<br>
| |
| | <br>
| |
| |-
| |
| | DHHC13<br>
| |
| | ZDHHC24<br>
| |
| | huntingtin<br>
| |
| | ER<br>
| |
| | <br>
| |
| |-
| |
| | DHHC14<br>
| |
| | ZDHHC14<br>
| |
| | <br>
| |
| | ER<br>
| |
| | <br>
| |
| |-
| |
| | DHHC15<br>
| |
| | ZDHHC15<br>
| |
| | PSD95, GAP43, GABAAγ2, BACE1, CD151<br>
| |
| | ゴルジ体<br>
| |
| | X連鎖神経遅滞<br>
| |
| |-
| |
| | DHHC16<br>
| |
| | ZDHHC16<br>
| |
| | <br>
| |
| | ER<br>
| |
| | <br>
| |
| |-
| |
| | DHHC17<br>
| |
| |
| |
| ZDHHC17
| |
| | |
| HIP14<br>
| |
| | |
| | SNAP25, huntingtin, <br>
| |
| | ゴルジ体<br>
| |
| | ハンチントン病、癌<br>
| |
| |-
| |
| | DHHC18<br>
| |
| | ZDHHC18<br>
| |
| | <br>
| |
| | ゴルジ体<br>
| |
| | <br>
| |
| |-
| |
| | DHHC19<br>
| |
| | ZDHHC19<br>
| |
| | R-Ras<br>
| |
| | ER<br>
| |
| | <br>
| |
| |-
| |
| | DHHC20<br>
| |
| | ZDHHC20<br>
| |
| | BACE1, ABC transporter 1<br>
| |
| | 細胞膜<br>
| |
| | <br>
| |
| |-
| |
| | DHHC21<br>
| |
| | ZDHHC21<br>
| |
| | eNOS, Lck, Fyn, ABC transporter 1<br>
| |
| | 細胞膜<br>
| |
| | <br>
| |
| |-
| |
| | DHHC22<br>
| |
| | ZDHHC13<br>
| |
| | <br>
| |
| | ER/ゴルジ体<br>
| |
| | <br>
| |
| |-
| |
| | DHHC23<br>
| |
| | ZDHHC25<br>
| |
| | <br>
| |
| | <br>
| |
| | <br>
| |
| |-
| |
| | <br>
| |
| | ZDHHC22<br>
| |
| | <br>
| |
| | <br>
| |
| | <br>
| |
| |}
| |
| | |
| <br>
| |