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グルタミン酸受容体 (ソースを閲覧)

2015年5月5日 (火) 13:01時点における版

3,034 バイト追加、 2015年5月5日 (火)

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@@ 61行目: / 61行目: @@
 ''詳細は[[NMDA型グルタミン酸受容体]]の項目参照''
+{| class="wikitable"
+|-
+! Mammalian receptor family
+! Subunit
+(Old nomenclature)
+! Gene
+! Chromosome<br/>(human)
+|-
+| rowspan="4" align="center" | [[AMPA receptor|AMPA]]
+| GluA1 (GluR<sub>1</sub>)
+| ''[[GRIA1]]''
+| align="center" | 5q33
+|-
+| GluA2 (GluR<sub>2</sub>)
+| ''[[GRIA2]]''
+| align="center" | 4q32-33
+|-
+| GluA3 (GluR<sub>3</sub>)
+| ''[[GRIA3]]''
+| align="center" | Xq25-26
+|-
+| GluA4 (GluR<sub>4</sub>)
+| ''[[GRIA4]]''
+| align="center" | 11q22-23
+|-
+| rowspan="5" align="center" | [[Kainate receptor|Kainate]]
+| GluK1 (GluR<sub>5</sub>)
+| ''[[GRIK1]]''
+| align="center" | 21q21.1-22.1
+|-
+| GluK2 (GluR<sub>6</sub>)
+| ''[[GRIK2]]''
+| align="center" | 6q16.3-q21
+|-
+| GluK3 (GluR<sub>7</sub>)
+| ''[[GRIK3]]''
+| align="center" | 1p34-p33
+|-
+| GluK4 (KA-1)
+| ''[[GRIK4]]''
+| align="center" | 11q22.3
+|-
+| GluK5 (KA-2)
+| ''[[GRIK5]]''
+| align="center" | 19q13.2
+|-
+| rowspan="7" align="center" | [[NMDA receptor|NMDA]]
+| GluN1(NR1)
+| ''[[GRIN1]]''
+| align="center" | 9q34.3
+|-
+| GluN2A (NR2A)
+| ''[[GRIN2A]]''
+| align="center" | 16p13.2
+|-
+| GluN2B (NR2B)
+| ''[[GRIN2B]]''
+| align="center" | 12p12
+|-
+| GluN2C (NR2C)
+| ''[[GRIN2C]]''
+| align="center" | 17q24-q25
+|-
+| GluN2D (NR2D)
+| ''[[GRIN2D]]''
+| align="center" | 19q13.1qter
+|-
+| GluN3A (NR3A)
+| ''[[GRIN3A]]''
+|  align="center" | 9q31.1
+|-
+| GluN3B (NR3B)
+| ''[[GRIN3B]]''
+|  align="center" | 19p13.3
+|}
 ==代謝活性型グルタミン酸受容体==
@@ 75行目: / 152行目: @@
 ===サブグループIII===
 　[[L-AP4|<small>L</small>−AP4]]により活性化され、cAMP産生を抑制する。また、サブグループIIと同様にGIRKを活性化する。[[mGluR4]]、[[mGluR6]]、[[mGluR7]]、[[mGluR8]]が属する。
+{| class="wikitable"
+|-
+! Group
+! Receptor
+! Gene
+! Chromosome<br/>(human)
+! Effect
+|-
+| rowspan="2" align="center" | 1
+| mGluR<sub>1</sub>
+|  ''[[Metabotropic glutamate receptor 1|GRM1]]''
+| align="center" | 6q24
+| Increase in Ca<sup>2+</sup> concentration in the cytoplasm.
+|-
+| mGluR<sub>5</sub>
+| ''[[Metabotropic glutamate receptor 5|GRM5]]''
+| align="center" | 11q14.3
+| Release of K<sup>+</sup> from the cell by activating K<sup>+</sup> ionic channels
+|-
+| rowspan="2" align="center" | 2
+| mGluR<sub>2</sub>
+| ''[[Metabotropic glutamate receptor 2|GRM2]]''
+| align="center" | 3p21.2
+| rowspan="2" | Inhibition of [[adenylyl cyclase]] causing shutdown of the [[cAMP-dependent pathway]]<br />And therefore decreasing amount of [[cyclic adenosine monophosphate|cAMP]]
+|-
+| mGluR<sub>3</sub>
+| ''[[GRM3]]''
+| align="center" | 7q21.1-q21.2
+|-
+| rowspan="4" align="center" | 3
+| mGluR<sub>4</sub>
+| ''[[Metabotropic glutamate receptor 4|GRM4]]''
+| align="center" | 6p21.3
+| rowspan="4" | Activation of Ca<sup>2+</sup> channels, allowing more Ca<sup>2+</sup> to enter the cell<ref name="con1">{{cite journal | author = Conn PJ et al. | title = Metabotropic glutamate receptors in the basal ganglia motor circuit | journal = Nature Reviews Neuroscience  | volume = 6 | issue = 10 | pages = 787–98 | year = 2005 | pmid = 16276355 | doi = 10.1038/nrn1763}}</ref>
+|-
+| mGluR<sub>6</sub>
+| ''[[Metabotropic glutamate receptor 6|GRM6]]''
+| align="center" | 5q35
+|-
+| mGluR<sub>7</sub>
+| ''[[Metabotropic glutamate receptor 7|GRM7]]''
+| align="center" | 3p26-p25
+|-
+| mGluR<sub>8</sub>
+| ''[[Metabotropic glutamate receptor 8|GRM8]]''
+| align="center" | 7q31.3-q32.1
+|}
 ==関連項目==