テンプレート:PBB/134

Adenosine A1 receptor
Identifiers
Symbols	ADORA1; RDC7
External IDs	OMIM: 102775 MGI: 99401 HomoloGene: 20165 IUPHAR: A1 GeneCards: ADORA1 Gene
Gene Ontology Molecular function • G-protein coupled adenosine receptor activity • G-protein coupled receptor binding • purine nucleoside binding • phospholipase C activity • protein binding • G-protein beta/gamma-subunit complex binding • heterotrimeric G-protein binding • protein heterodimerization activity Cellular component • endoplasmic reticulum • plasma membrane • integral component of plasma membrane • postsynaptic density • basolateral plasma membrane • axolemma • asymmetric synapse • presynaptic membrane • neuronal cell body • terminal bouton • dendritic spine • postsynaptic membrane • presynaptic active zone Biological process • activation of MAPKK activity • temperature homeostasis • response to hypoxia • adenosine receptor signaling pathway • regulation of respiratory gaseous exchange by neurological system process • negative regulation of acute inflammatory response • negative regulation of leukocyte migration • positive regulation of peptide secretion • regulation of glomerular filtration • protein targeting to membrane • phagocytosis • inflammatory response • signal transduction • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway • cell-cell signaling • nervous system development • negative regulation of cell proliferation • negative regulation of glutamate secretion • lipid catabolic process • negative regulation of synaptic transmission, GABAergic • positive regulation of nucleoside transport • negative regulation of neurotrophin production • positive regulation of protein dephosphorylation • negative regulation of renal sodium excretion • negative regulation of circadian sleep/wake cycle, non-REM sleep • negative regulation of apoptotic process • positive regulation of potassium ion transport • positive regulation of epidermal growth factor-activated receptor activity • negative regulation of blood pressure • positive regulation of blood pressure • negative regulation of vasodilation • negative regulation of hormone secretion • regulation of synaptic plasticity • cognition • detection of temperature stimulus involved in sensory perception of pain • negative regulation of lipid catabolic process • regulation of sensory perception of pain • negative regulation of synaptic transmission, glutamatergic • negative regulation of cardiac muscle contraction • regulation of excitatory postsynaptic membrane potential • relaxation of vascular smooth muscle • negative regulation of mucus secretion • apoptotic signaling pathway • negative regulation of long term synaptic depression Sources: Amigo / QuickGO
RNA expression pattern
ファイル:PBB GE ADORA1 216220 s at tn.png
ファイル:PBB GE ADORA1 205481 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	134	11539
Ensembl	ENSG00000163485	ENSMUSG00000042429
UniProt	P30542	Q60612
RefSeq (mRNA)	NM_000674	NM_001008533
RefSeq (protein)	NP_000665	NP_001008533
Location (UCSC)	Chr 1: 203.09 – 203.17 Mb	Chr 1: 134.2 – 134.24 Mb
PubMed search	[1]	[2]