3β-Hydroxytibolone

3β-Hydroxytibolone
ファイル:3β-Hydroxytibolone.svg
Systematic (IUPAC) name
	(3S,7R,8R,9S,13S,14S,17R)-17-ethynyl-7,13-dimethyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	100239-45-0
ATC code	?
PubChem	CID 9839851
ChemSpider	8015569
UNII	TEP8IU9GMR
Synonyms	ORG-30126; 7α-Methyl-17α-ethynylestr-5(10)-ene-3β,17β-diol
Chemical data
Formula	C21H30O2
	InChI InChI=1S/C21H30O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,15,17-19,22-23H,5-12H2,2-3H3/t13-,15+,17-,18+,19-,20+,21+/m1/s1; Key:YLEUWNOTNJZCBN-XAAPQAIWSA-N;

3β-Hydroxytibolone (developmental code name ORG-30126) is a synthetic steroidal estrogen which was never marketed.^[1]^[2] Along with 3α-hydroxytibolone and δ⁴-tibolone, it is a major active metabolite of tibolone, and 3α-hydroxytibolone and 3β-hydroxytibolone are thought to be responsible for the estrogenic activity of tibolone.^[1]^[2]

References

↑ ^1.0 ^1.1 Kuhl, H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 (sup1): 3–63. doi:10.1080/13697130500148875. ISSN 1369-7137. PMID 16112947. S2CID 24616324.
↑ ^2.0 ^2.1 Escande A, Servant N, Rabenoelina F, Auzou G, Kloosterboer H, Cavaillès V, Balaguer P, Maudelonde T (2009). "Regulation of activities of steroid hormone receptors by tibolone and its primary metabolites". J. Steroid Biochem. Mol. Biol. 116 (1–2): 8–14. doi:10.1016/j.jsbmb.2009.03.008. PMID 19464167. S2CID 18346113.