β-Zearalenol

β-Zearalenol
ファイル:Beta Zearalenol.svg
Systematic (IUPAC) name
	(2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	71030-11-0
ATC code	?
PubChem	CID 6437352
ChemSpider	5908979
UNII	35E809PP7O
KEGG	C14751
ChEBI	CHEBI:35072
Synonyms	beta-Zearalenol; beta-trans-Zearalenol
Chemical data
Formula	C18H24O5
	InChI InChI=1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14-/m0/s1; Key:FPQFYIAXQDXNOR-PMRAARRBSA-N;

β-Zearalenol is a nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in Fusarium spp.^[1] It is the β epimer of α-zearalenol and along with α-zearalenol is a major metabolite of zearalenone formed mainly in the liver but also to a lesser extent in the intestines during first-pass metabolism.^[2]^[3] A relatively high proportion of α-zearalenol is formed from zearalenone compared to β-zearalenol in humans.^[3] β-Zearalenol is about the same or slightly less potent as an estrogen relative to zearalenone.^[1]

References

↑ ^{以下の位置に戻る: 1.0} ^1.1 Bottalico A, Logrieco A, Visconti A (January 1989). "Fusarium species and their mycotoxins in infected cereals in the field and in stored grains". In Chelkowski J (ed.). Fusarium: Mycotoxins, Taxonomy, Pathogenicity. Elsevier Science. pp. 85–119. ISBN 978-1-4832-9785-9.
↑ Alldrick AJ, Hajšelová M (January 2004). "Zearalenone". In Magan N, Olsen M (eds.). Mycotoxins in Food: Detection and Control. Woodhead Publishing. pp. 353–366. ISBN 978-1-85573-733-4.
↑ ^{以下の位置に戻る: 3.0} ^3.1 Eriksen GS, Alexander J (1998). "Zearalenone". Fusarium Toxins in Cereals: A Risk Assessment. Nordic Council of Ministers. pp. 61–. ISBN 978-92-893-0149-7.