テンプレート:PBB/2668

Glial cell derived neurotrophic factor
GDNF structure
[show]Available structures PDB 2V5E​, 3FUB​
Identifiers
Symbols	GDNF; ATF1; ATF2; HFB1-GDNF; HSCR3
External IDs	OMIM: 600837 MGI: 107430 HomoloGene: 433 GeneCards: GDNF Gene
[show]Gene Ontology Molecular function • receptor binding • growth factor activity • protein homodimerization activity Cellular component • extracellular region Biological process • metanephros development • ureteric bud development • branching involved in ureteric bud morphogenesis • neural crest cell migration • organ induction • postsynaptic membrane organization • anti-apoptosis • signal transduction • nervous system development • axon guidance • adult locomotory behavior • postganglionic parasympathetic nervous system development • peristalsis • neuron projection development • positive regulation of monooxygenase activity • positive regulation of dopamine secretion • negative regulation of neuron apoptosis • positive regulation of transcription from RNA polymerase II promoter • mRNA stabilization • enteric nervous system development • sympathetic nervous system development • regulation of dopamine uptake • regulation of morphogenesis of a branching structure • positive regulation of ureteric bud formation • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • positive regulation of branching involved in ureteric bud morphogenesis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2668	14573
Ensembl	ENSG00000168621	ENSMUSG00000022144
UniProt	P39905	P48540
RefSeq (mRNA)	NM_000514.3	NM_010275.2
RefSeq (protein)	NP_000505.1	NP_034405.1
Location (UCSC)	Chr 5: 37.81 – 37.84 Mb	Chr 15: 7.76 – 7.79 Mb
PubMed search	[1]	[2]