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Some androstenedione is also secreted into the [[blood plasma|plasma]], and may be converted in peripheral tissues to testosterone {{Production rates, secretion rates, clearance rates, and blood levels of major sex hormones}}

…tle = Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT {{Production rates, secretion rates, clearance rates, and blood levels of major sex hormones}}

…receptor down-regulation in rat liver epithelial and aortic smooth muscle cells | journal = Gender Medicine | volume = 9 | issue = 2 | pages = 76–93 | da

…ind sex hormone binding globulin or increase its production by human HepG2 cells |journal=Climacteric |volume=11 |issue=Suppl 1 |pages=41–6 |doi=10.1080/1 {{Relative affinities of estrogens for steroid hormone receptors and blood proteins}}

…lifies profibrogenic effects of free fatty acids on human hepatic stellate cells | journal = Hepatology Research | volume = 39 | issue = 6 | pages = 601–6 …s = Liu Y, Ma W, Zhang P, He S, Huang D | title = Effect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials | journal = Clini

Genistein influences multiple [[biochemical]] functions in living cells: …nd genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy |journal=Mol

…d 82 ± 45 pg/ml of the compound in normal [[male]] and [[female]] [[serum (blood)|serum]], respectively.<ref name="pmid581118">{{cite journal | vauthors =…

…similar to that of [[estrogen]], it can interact with [[immunoassay]]s for blood [[estradiol]] concentrations and show falsely elevated results.<ref name=HM …ypersensitivity reactions, loss of appetite, headache, [[Venous thrombosis|blood clots in veins]], hot flushes, vomiting, diarrhea, elevated [[bilirubin]],

…cortical insufficiency]], [[adrenogenital syndrome]], [[hypercalcemia|high blood calcium]], [[thyroiditis]], [[rheumatoid arthritis]], [[dermatitis]], [[ast …11250647 | doi = 10.1677/joe.0.1690065 | doi-access = free }}</ref> Inside cells it interacts with [[corticosteroid receptor]]s.<ref name="isbn1-4377-1753-5

…tosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels | journal = Endocrine Reviews | volume = 38 | issue = 3 | pages = 22 …nd at high dosages can cause [[polycythemia]] (overproduction of red blood cells), which can greatly increase the risk of [[thrombosis|thrombic]] events suc

…nd at high dosages can cause [[polycythemia]] (overproduction of red blood cells), which can greatly increase the risk of [[thrombosis|thrombic]] events suc

…ceptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells | journal = PLOS ONE | volume = 7 | issue = 11 | pages = e50167 | year = 20 …rm]]. Progesterone is anti-[[mitosis|mitogenic]] in endometrial epithelial cells, and as such, mitigates the tropic effects of [[estrogen]].<ref name="pmid2

…tor modulator]] (SERM) and works by decreasing the growth of breast cancer cells.<ref name=AHFS2015/><ref>{{Cite web |title=Selective estrogen receptor modu …well-being. Tamoxifen has been identified and used to effectively improve blood flow, reduce uterine contractility and pain in dysmenorrhea patients.<ref…

…journal | vauthors = Hussain SF | title = Progestogen-only pills and high blood pressure: is there an association? A literature review | journal = Contrace …| pages = 4568–72 | date = December 1998 | pmid = 9845522 | doi = 10.1182/blood.V92.12.4568 }}</ref>

Rare adverse events (<1% of people) include: [[hypertriglyceridemia|high blood level of triglycerides]], [[hepatitis|liver inflammation]], reversible [[al …ene analogs with activity in vitro and in vivo against human breast cancer cells | journal = Biochemical Pharmacology | volume = 55 | issue = 6 | pages = 84

…30 by estriol prevents growth stimulation of triple-negative breast cancer cells by 17β-estradiol | journal = BMC Cancer | volume = 14 | issue = 1 | pages {{Relative affinities of estrogens for steroid hormone receptors and blood proteins}}

…"Kuhl2005"/> These differences result in DES having an increased risk of [[blood clot]]s, [[cardiovascular disease|cardiovascular issues]], and certain othe ===Blood clots and cardiovascular issues===

…veditors = Speroff L | chapter = Women's Hormonal Health Issues | title = Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care. |year …: Prognosis, Treatment, and Prevention | chapter = Proliferation of Breast Cells by Steroid Hormones and Their Metabolites | url = https://books.google.com/

…one, and possibly also via direct [[cytotoxic]] effects on prostate cancer cells.<ref name="HongHolland2010" /><ref name="pmid14532759" /><ref name="CossJon …ible side effects of estrogens may include [[high blood pressure]], [[high blood sugar]], enlargement of [[uterine fibroid]]s, [[melasma]], [[vaginal yeast