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- …DES having an increased risk of [[blood clot]]s, [[cardiovascular disease|cardiovascular issues]], and certain other adverse effects.<ref name="Kuhl2005"/> …favor of oral synthetic estrogens like DES due to their much lower risk of cardiovascular toxicity.<ref name="pmid17239273">{{cite journal |vauthors= Lycette JL, Bla98キロバイト (13,218 語) - 2025年3月18日 (火) 19:29