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{{box|text=　サブスタンスP substance P(SP)は、ウマの脳および腸管に存在し、血圧を下降させ、平滑筋を収縮させる物質として、1931年にvon EulerとGaddumによって見出され、1971年に単離された神経ペプチドである。類似の構造を持つペプチドと共に、タキキニンtachykininsと総称される。SPに高親和性を持つNK1受容体を介して、様々な細胞内情報伝達系を活性化し、複数のイオンチャネルを修飾する。SPおよびNK1受容体は、神経細胞だけでなく、末梢の非神経細胞にも発現している。従って痛覚、神経原性炎症、情動、報酬系等、広範囲な生理機能と疾患病態に関与している。}}
英語名：substance P(SP)
 
{{box|text=　サブスタンスPは、ウマの脳および腸管に存在し、血圧を下降させ、平滑筋を収縮させる物質として、1931年にvon EulerとGaddumによって見出され、1971年に単離された神経ペプチドである。類似の構造を持つペプチドと共に、タキキニンtachykininsと総称される。SPに高親和性を持つNK1受容体を介して、様々な細胞内情報伝達系を活性化し、複数のイオンチャネルを修飾する。SPおよびNK1受容体は、神経細胞だけでなく、末梢の非神経細胞にも発現している。従って痛覚、神経原性炎症、情動、報酬系等、広範囲な生理機能と疾患病態に関与している。}}


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== 参考文献 ==
== 参考文献 ==
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