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2012年1月22日 (日) 17:54時点におけるTfuruya (トーク | 投稿記録)による版

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表1 主なS-パルミトイル化タンパク質
ファミリー
主な例
Signalling protein
 Small GTPase
 Gα subunit
 Src family
 Others

H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10
Gαs, Gαq, Gαi2
Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk
GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2

Transmembrane
 Ion channel
 GPCR
 Cell adhesion molecule
 Transporter
 Matrix metalloproteinase
 Myelin associated
 Secretase
 Cell death signalling

GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1
Rhodopsin, β2-adrenergic receptor,
Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC
EAAT1, EAAT3
MT1-MMP
PLP, GPM6A
β-secretase, Nicastrin
Fas, NGFR
Adaptor, Scaffold
PSD95, PSD93α/β, GRIP1/2, Delphilin
Viral protein
Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160
N-palmitoylated protein
Sonic Hedgehog, Wnt, Ghrelin



表2 パルミチルトランスフェラーゼ



酵素 別名 主な基質 局在(過剰発現系) 関連疾患
DHHC1 ZDHHC1
ER
DHHC2 ZDHHC2 PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1
ER/ゴルジ体

DHHC3

ZDHHC3

GODZ

PSD95, SNAP25, Gαs, GABAAγ2, eNOS,
ゴルジ体

DHHC4
ZDHHC4
BACE1
ゴルジ体

DHHC5
ZDHHC5
STREX


DHHC6
ZDHHC6



DHHC7
ZDHHC7
PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS
ゴルジ体

DHHC8
ZDHHC8
PSD95, SNAP25, eNOS, paralemmin-1
ゴルジ体
統合失調症
DHHC9
ZDHHC9
H-RAS, N-Ras
ER/ゴルジ体
癌、X連鎖神経遅滞
DHHC10
ZDHHC11

ER

DHHC11
ZDHHC23
NIDD

ER

DHHC12
ZDHHC12
ABC transporter A1
ER/ゴルジ体

DHHC13
ZDHHC24
huntingtin
ER

DHHC14
ZDHHC14

ER

DHHC15
ZDHHC15
PSD95, GAP43, GABAAγ2, BACE1, CD151
ゴルジ体
X連鎖神経遅滞
DHHC16
ZDHHC16

ER

DHHC17

ZDHHC17

HIP14

SNAP25, huntingtin,
ゴルジ体
ハンチントン病、癌
DHHC18
ZDHHC18

ゴルジ体

DHHC19
ZDHHC19
R-Ras
ER

DHHC20
ZDHHC20
BACE1, ABC transporter 1
細胞膜

DHHC21
ZDHHC21
eNOS, Lck, Fyn, ABC transporter 1
細胞膜

DHHC22
ZDHHC13

ER/ゴルジ体

DHHC23
ZDHHC25




ZDHHC22



 


Category Family N-Myristoylated protein
Kinase/Phosphatase Src family kinase Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk
Abl tyrosine kinase c-Abl, Arg

Ser/Thr kinase cAMP-dependent protein kinase, AKAP18

phosphatase Calcineurin B
GTP-binding protein Gα i1, Gαo, Gαt, Gαx
ADP-ribosylation factor Arf-1, Arf-3, Arf-5, Arf-6
Ca2+ binding /
EF hand protein
Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,
Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1
Membrane/cytoskeletal-
bound protein
MARCKS, Annexin XIII,
Rapsyn, Pallidin, Hisactophilin 2
Viral protein Gag protein HIV-1, Moloney murine, sarcoma virus, Friend murine,
leukemia virus
Others HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,
Herpes simplex virus
Others eNOS
Caspase-cleavage
post-translational
N-myristoylated protein
β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,
MST3, PKC,