テンプレート:PBB/4311

Membrane metallo-endopeptidase

The structure of the neprilysin ectodomain in complex with a zinc-chelating inhibitor. The zinc atom is shown as a gray sphere and the inhibitor is shown in green. Rendering based on 1r1h.

Available structures
PDB	1DMT, 1R1H, 1R1I, 1R1J, 1Y8J, 2QPJ, 2YB9

Identifiers

Symbols

MME; CALLA; CD10; NEP; SFE

External IDs

OMIM: 120520 MGI: 97004 HomoloGene: 5275 GeneCards: MME Gene

EC number

3.4.24.11

Gene Ontology
Molecular function	• endopeptidase activity • metalloendopeptidase activity • protein binding • zinc ion binding • peptide binding • metal ion binding
Cellular component	• cytoplasm • plasma membrane • integral to plasma membrane • brush border • synaptic vesicle • integral to membrane • axon • dendrite • neuron projection terminus • synapse
Biological process	• kidney development • proteolysis • peptide metabolic process • sensory perception of pain • creatinine metabolic process • beta-amyloid metabolic process • cellular response to cytokine stimulus • cellular response to UV-A • cellular response to UV-B • replicative senescence
Sources: Amigo / QuickGO