テンプレート:PBB/85358

SH3 and multiple ankyrin repeat domains 3
PDB rendering based on 2f3n.
Identifiers
Symbols	SHANK3; DEL22q13.3; PROSAP2; PSAP2; SCZD15; SPANK-2
External IDs	OMIM: 606230 MGI: 1930016 HomoloGene: 75163 GeneCards: SHANK3 Gene
Gene Ontology Molecular function • protein binding • protein C-terminus binding • SH3 domain binding • GKAP/Homer scaffold activity • ionotropic glutamate receptor binding • scaffold protein binding Cellular component • cytoplasm • plasma membrane • postsynaptic density • cell junction • neuron spine • synapse • postsynaptic membrane Biological process • striatal medium spiny neuron differentiation • social behavior • locomotory exploration behavior • negative regulation of cell volume • positive regulation of long-term neuronal synaptic plasticity • brain morphogenesis • positive regulation of synapse structural plasticity • positive regulation of synaptic transmission, glutamatergic • dendritic spine morphogenesis • vocalization behavior • postsynaptic density assembly • positive regulation of excitatory postsynaptic membrane potential • regulation of behavioral fear response • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	85358	58234
Ensembl	ENSG00000251322	ENSMUSG00000022623
UniProt	F2Z3L0	Q4ACU6
RefSeq (mRNA)	NM_001080420.1	NM_021423.3
RefSeq (protein)	NP_001073889.1	NP_067398.2
Location (UCSC)	Chr 22: 51.11 – 51.17 Mb	Chr 15: 89.33 – 89.39 Mb
PubMed search	[1]	[2]