テンプレート:PBB/9353

Slit guidance ligand 2
	PDB 2V70.による。
Available structures
PDB	2V70, 2V9S, 2V9T, 2WFH
Identifiers
Symbols	SLIT2; SLIL3; Slit-2
External IDs	OMIM: 603746 MGI: 1315205 HomoloGene: 3516 GeneCards: SLIT2 Gene
Gene Ontology
Molecular function	• GTPase inhibitor activity; • calcium ion binding; • protein binding; • heparin binding; • identical protein binding; • protein homodimerization activity; • laminin-1 binding; • proteoglycan binding; • heparan sulfate proteoglycan binding; • chemorepellent activity; • Roundabout binding;
Cellular component	• extracellular region; • extracellular space; • cytoplasm; • plasma membrane; • cell surface; • membrane; • extracellular exosome;
Biological process	• metanephros development; • ureteric bud development; • in utero embryonic development; • negative regulation of protein phosphorylation; • cell migration involved in sprouting angiogenesis; • negative regulation of leukocyte chemotaxis; • axon guidance; • motor neuron axon guidance; • negative regulation of cell proliferation; • negative regulation of lamellipodium assembly; • negative regulation of endothelial cell migration; • negative regulation of gene expression; • negative regulation of smooth muscle cell migration; • single organismal cell-cell adhesion; • spinal cord development; • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; • chemorepulsion involved in postnatal olfactory bulb interneuron migration; • corticospinal neuron axon guidance through spinal cord; • negative regulation of cell growth; • negative regulation of cell migration; • negative regulation of axon extension; • negative regulation of actin filament polymerization; • retinal ganglion cell axon guidance; • response to nutrient levels; • cellular response to hormone stimulus; • dorsal/ventral axon guidance; • negative regulation of GTPase activity; • Roundabout signaling pathway; • positive regulation of apoptotic process; • negative regulation of vascular permeability; • branching morphogenesis of an epithelial tube; • axon extension involved in axon guidance; • negative regulation of inflammatory response; • positive regulation of axonogenesis; • negative chemotaxis; • induction of negative chemotaxis; • negative regulation of small GTPase mediated signal transduction; • response to cortisol; • mammary duct terminal end bud growth; • apoptotic process involved in luteolysis; • negative regulation of chemokine-mediated signaling pathway; • cellular response to heparin; • negative regulation of smooth muscle cell chemotaxis; • negative regulation of mononuclear cell migration; • negative regulation of neutrophil chemotaxis; • negative regulation of monocyte chemotaxis; • negative regulation of retinal ganglion cell axon guidance; • negative regulation of cellular response to growth factor stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

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テンプレート:PBB/9353

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