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「低分子量Gタンパク質」の版間の差分
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{{Pfam_box | |||
| Symbol = Ras | |||
| Name = | |||
| image = Hras surface colored by conservation.png | |||
| width = | |||
| caption = [[HRAS|H-Ras]] structure [[Protein Data Bank|PDB]] 121p, surface colored by conservation in [[Pfam]] seed alignment: gold, most conserved; dark cyan, least conserved. | |||
| Pfam= PF00071 | |||
| InterPro= IPR013753 | |||
| SMART= | |||
| PROSITE = PDOC00017 | |||
| SCOP = 5p21 | |||
| TCDB = | |||
| CDD = cd00882 | |||
| OPM family= | |||
| OPM protein= 1uad | |||
| PDB= | |||
{{PDB3|2fol}}A:13-174 {{PDB3|1ukv}}Y:10-171 {{PDB3|1yzn}}A:10-171 | |||
{{PDB3|2bcg}}Y:10-171 {{PDB3|1g17}}B:22-182 {{PDB3|1g16}}C:22-182 | |||
{{PDB3|3rab}}A:24-185 {{PDB3|1zbd}}A:24-185 {{PDB3|2ew1}}A:11-172 | |||
{{PDB3|1x3s}}A:10-171 {{PDB3|1z0k}}A:10-171 {{PDB3|2bme}}A:10-171 | |||
{{PDB3|2bmd}}A:10-171 {{PDB3|1yu9}}A:10-171 {{PDB3|2aed}}A:13-174 | |||
{{PDB3|1z0f}}A:13-174 {{PDB3|1z0a}}D:8-169 {{PDB3|2a5j}}A:8-169 | |||
{{PDB3|1oiv}}B:13-172 {{PDB3|1yzk}}A:13-174 {{PDB3|1oix}}A:13-172 | |||
{{PDB3|1oiw}}A:13-172 {{PDB3|1z06}}A:35-201 {{PDB3|1huq}}A:23-182 | |||
{{PDB3|1z0d}}C:23-183 {{PDB3|1z07}}A:23-182 {{PDB3|1r2q}}A:22-183 | |||
{{PDB3|1n6r}}A:22-183 {{PDB3|1ek0}}A:9-173 {{PDB3|1yvd}}A:7-168 | |||
{{PDB3|1z0j}}A:7-168 {{PDB3|2fg5}}A:7-168 {{PDB3|1z08}}A:21-182 | |||
{{PDB3|1yzt}}B:21-182 {{PDB3|1yzu}}B:21-182 {{PDB3|1z0i}}A:21-182 | |||
{{PDB3|1yzq}}A:15-176 {{PDB3|1d5c}}A:13-172 {{PDB3|1t91}}C:10-175 | |||
{{PDB3|1vg8}}D:10-175 {{PDB3|1vg9}}H:10-175 {{PDB3|1vg1}}A:10-175 | |||
{{PDB3|1vg0}}B:10-175 {{PDB3|1ky3}}A:10-178 {{PDB3|1ky2}}A:10-178 | |||
{{PDB3|1yzl}}A:9-174 {{PDB3|1wms}}B:9-174 {{PDB3|1s8f}}B:9-174 | |||
{{PDB3|2f7s}}A:11-183 {{PDB3|1z22}}A:11-171 {{PDB3|1z2a}}A:11-171 | |||
{{PDB3|1plj}} :5-165 {{PDB3|1ctq}}A:5-165 {{PDB3|1crp}} :5-165 | |||
{{PDB3|821p}} :5-165 {{PDB3|2ery}}B:16-177 {{PDB3|2fn4}}A:31-192 | |||
{{PDB3|1x1s}}A:15-177 {{PDB3|1x1r}}A:15-177 {{PDB3|1u90}}A:16-177 | |||
{{PDB3|1u8z}}A:16-177 {{PDB3|1u8y}}B:16-177 {{PDB3|1uad}}B:16-177 | |||
{{PDB3|2bov}}A:16-177 {{PDB3|2a78}}A:16-177 {{PDB3|3rap}}R:5-166 | |||
{{PDB3|1kao}} :5-166 {{PDB3|2rap}} :5-166 {{PDB3|1c1y}}A:5-167 | |||
{{PDB3|1gua}}A:5-167 {{PDB3|1xtr}}A:8-169 {{PDB3|1xtq}}A:8-169 | |||
{{PDB3|1xts}}A:8-169 {{PDB3|2erx}}B:9-171 {{PDB3|1a4r}}B:5-178 | |||
{{PDB3|1kmq}}A:7-180 {{PDB3|1tx4}}B:7-179 {{PDB3|1cxz}}A:7-180 | |||
{{PDB3|1m7b}}A:25-199 {{PDB3|1gwn}}A:25-199 {{PDB3|2bku}}A:12-170 | |||
{{PDB3|3ran}}A:12-170 {{PDB3|1qg4}}B:12-170 {{PDB3|1byu}}A:12-170 | |||
{{PDB3|2atv}}A:8-169 | |||
}} | |||
英：small G protein 独：kleine G-Protein 仏：petites protéines G | 英：small G protein 独：kleine G-Protein 仏：petites protéines G | ||
| 32行目: | 79行目: | ||
Sar (Secretion-associated and Ras-related)/Arf (ADP-ribosylation factor: ARF)は細胞内の小胞輸送、[[アクチン]]線維のリモデリングの制御のほか、[[wikipedia:ja:NADPHオキシダーゼ|NADPHオキシダーゼ]]、[[wikipedia:ja:ホスホリパーゼD|ホスホリパーゼD]]、[[ホスファチジルイノシトール#ホスファチジルイノシトールキナーゼ|ホスファチジルイノシトールキナーゼ]]などを活性化する。 | Sar (Secretion-associated and Ras-related)/Arf (ADP-ribosylation factor: ARF)は細胞内の小胞輸送、[[アクチン]]線維のリモデリングの制御のほか、[[wikipedia:ja:NADPHオキシダーゼ|NADPHオキシダーゼ]]、[[wikipedia:ja:ホスホリパーゼD|ホスホリパーゼD]]、[[ホスファチジルイノシトール#ホスファチジルイノシトールキナーゼ|ホスファチジルイノシトールキナーゼ]]などを活性化する。 | ||
{|class="wikitable" style="text-align:center" | |||
|+低分子量Gタンパク質ファミリー（Wikipediaより一部改変） | |||
|- | |||
! サブファミリー !! 機能 !! メンバー | |||
|- | |||
| [[Ras subfamily|Ras]] | |||
| [[細胞増殖]] | |||
| align=left | [[DIRAS1]]; [[DIRAS2]]; [[DIRAS3]]; [[ERAS]]; [[GEM]]; [[HRAS]]; [[KRAS]]; [[MRAS]]; [[NKIRAS1]]; [[NKIRAS2]]; [[NRAS]]; [[RALA]]; [[RALB]]; [[RAP1A]]; [[RAP1B]]; [[RAP2A]]; [[RAP2B]]; [[RAP2C]]; [[RASD1]]; [[RASD2]]; [[RASL10A]]; [[RASL10B]]; [[RASL11A]]; [[RASL11B]]; [[RASL12]]; [[REM1]]; [[REM2]]; [[RERG]]; [[RERGL]]; [[RRAD]]; [[RRAS]]; [[RRAS2]] | |||
|- | |||
| [[Rho family|Rho]] | |||
| [[細胞骨格]]ダイナミクス/細胞形態 | |||
| align=left | [[RHOA]]; [[RHOB]]; [[RHOBTB1]]; [[RHOBTB2]]; [[RHOBTB3]]; [[RhoC|RHOC]]; [[RhoD|RHOD]]; [[RhoF|RHOF]]; [[RHOG]]; [[RhoH|RHOH]]; [[RHOJ]]; [[RHOQ]]; [[RHOU]]; [[RHOV]]; [[RND1]]; [[RND2]]; [[RND3]]; [[RAC1]]; [[RAC2]]; [[RAC3]]; [[CDC42]] | |||
|- | |||
| [[Rab]] | |||
| [[小胞輸送]] | |||
| align=left | [[RAB1A]]; [[RAB1B]]; [[RAB2]]; [[RAB3A]]; [[RAB3B]]; [[RAB3C]]; [[RAB3D]]; [[RAB4A]]; [[RAB4B]]; [[RAB5A]]; [[RAB5B]]; [[RAB5C]]; [[RAB6A]]; [[RAB6B]]; [[RAB6C]]; [[RAB7A]]; [[RAB7B]]; [[RAB7L1]]; [[RAB8A]]; [[RAB8B]]; [[RAB9]]; [[RAB9B]]; [[RABL2A]]; [[RABL2B]]; [[RABL4]]; [[RAB10]]; [[RAB11A]]; [[RAB11B]]; [[RAB12]]; [[RAB13]]; [[RAB14]]; [[RAB15]]; [[RAB17]]; [[RAB18]]; [[RAB19]]; [[RAB20]]; [[RAB21]]; [[RAB22A]]; [[RAB23]]; [[RAB24]]; [[RAB25]]; [[RAB26]]; [[RAB27A]]; [[RAB27B]]; [[RAB28]]; [[RAB2B]]; [[RAB30]]; [[RAB31]]; [[RAB32]]; [[RAB33A]]; [[RAB33B]]; [[RAB34]]; [[RAB35]]; [[RAB36]]; [[RAB37]]; [[RAB38]]; [[RAB39]]; [[RAB39B]]; [[RAB40A]]; [[RAB40AL]]; [[RAB40B]]; [[RAB40C]]; [[RAB41]]; [[RAB42]]; [[RAB43]] | |||
|- | |||
| [[Rap]] | |||
| [[細胞接着]] | |||
| align=left | [[RAP1A]]; [[RAP1B]]; [[RAP2A]]; [[RAP2B]]; [[RAP2C]] | |||
|- | |||
| [[Arf]] | |||
| [[小胞輸送]]<ref name=Munemitsu/> | |||
| align=left | [[ARF1]]; [[ARF3]]; [[ARF4]]; [[ARF5]]; [[ARF6]]; [[ARL1]]; [[ARL2]]; [[ARL3]]; [[ARL4]]; [[ARL5]]; [[ARL5C]]; [[ARL6]]; [[ARL7]]; [[ARL8]]; [[ARL9]]; [[ARL10A]]; [[ARL10B]]; [[ARL10C]]; [[ARL11]]; [[ARL13A]]; [[ARL13B]]; [[ARL14]]; [[ARL15]]; [[ARL16]]; [[ARL17]]; [[TRIM23]], [[ARL4D]]; [[ARFRP1]]; [[ARL13B]] | |||
|- | |||
| [[Ran]] | |||
| [[核輸送]] | |||
| align=left | [[RAN]] | |||
|- | |||
| [[Rheb]] | |||
| [[mTOR]]経路 | |||
| align=left | [[RHEB]]; [[RHEBL1]] | |||
|- | |||
| [[RRAD|RGK]] | |||
| | |||
| align=left | [[RRAD]]; [[GEM]]; [[REM]]; [[REM2]] | |||
|- | |||
| ''Rit'' | |||
| align=left | | |||
| align=left | [[RIT1]]; [[RIT2]] | |||
|- | |||
| ''Miro'' | |||
| [[ミトコンドリア]]輸送 | |||
| align=left | [[RHOT1]]; [[RHOT2]] | |||
|} | |||
未分類: | |||
* [[ARHGAP5]] | |||
* [[DNAJC27]] | |||
* [[GRLF1]] | |||
* [[RASEF]] | |||
== 活性調節機構 == | == 活性調節機構 == | ||