「グルタミン酸受容体」の版間の差分

編集の要約なし
編集の要約なし
 
61行目: 61行目:


''詳細は[[NMDA型グルタミン酸受容体]]の項目参照''
''詳細は[[NMDA型グルタミン酸受容体]]の項目参照''
{| class="wikitable"
|-
! Mammalian receptor family
! Subunit
(Old nomenclature)
! Gene
! Chromosome<br/>(human)
|-
| rowspan="4" align="center" | [[AMPA receptor|AMPA]]
| GluA1 (GluR<sub>1</sub>)
| ''[[GRIA1]]''
| align="center" | 5q33
|-
| GluA2 (GluR<sub>2</sub>)
| ''[[GRIA2]]''
| align="center" | 4q32-33
|-
| GluA3 (GluR<sub>3</sub>)
| ''[[GRIA3]]''
| align="center" | Xq25-26
|-
| GluA4 (GluR<sub>4</sub>)
| ''[[GRIA4]]''
| align="center" | 11q22-23
|-
| rowspan="5" align="center" | [[Kainate receptor|Kainate]]
| GluK1 (GluR<sub>5</sub>)
| ''[[GRIK1]]''
| align="center" | 21q21.1-22.1
|-
| GluK2 (GluR<sub>6</sub>)
| ''[[GRIK2]]''
| align="center" | 6q16.3-q21
|-
| GluK3 (GluR<sub>7</sub>)
| ''[[GRIK3]]''
| align="center" | 1p34-p33
|-
| GluK4 (KA-1)
| ''[[GRIK4]]''
| align="center" | 11q22.3
|-
| GluK5 (KA-2)
| ''[[GRIK5]]''
| align="center" | 19q13.2
|-
| rowspan="7" align="center" | [[NMDA receptor|NMDA]]
| GluN1(NR1)
| ''[[GRIN1]]''
| align="center" | 9q34.3
|-
| GluN2A (NR2A)
| ''[[GRIN2A]]''
| align="center" | 16p13.2
|-
| GluN2B (NR2B)
| ''[[GRIN2B]]''
| align="center" | 12p12
|-
| GluN2C (NR2C)
| ''[[GRIN2C]]''
| align="center" | 17q24-q25
|-
| GluN2D (NR2D)
| ''[[GRIN2D]]''
| align="center" | 19q13.1qter
|-
| GluN3A (NR3A)
| ''[[GRIN3A]]''
|  align="center" | 9q31.1
|-
| GluN3B (NR3B)
| ''[[GRIN3B]]''
|  align="center" | 19p13.3
|}


==代謝活性型グルタミン酸受容体==
==代謝活性型グルタミン酸受容体==
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===サブグループIII===
===サブグループIII===
 [[L-AP4|<small>L</small>−AP4]]により活性化され、cAMP産生を抑制する。また、サブグループIIと同様にGIRKを活性化する。[[mGluR4]]、[[mGluR6]]、[[mGluR7]]、[[mGluR8]]が属する。
 [[L-AP4|<small>L</small>−AP4]]により活性化され、cAMP産生を抑制する。また、サブグループIIと同様にGIRKを活性化する。[[mGluR4]]、[[mGluR6]]、[[mGluR7]]、[[mGluR8]]が属する。
{| class="wikitable"
|-
! Group
! Receptor
! Gene
! Chromosome<br/>(human)
! Effect
|-
| rowspan="2" align="center" | 1
| mGluR<sub>1</sub>
|  ''[[Metabotropic glutamate receptor 1|GRM1]]''
| align="center" | 6q24
| Increase in Ca<sup>2+</sup> concentration in the cytoplasm.
|-
| mGluR<sub>5</sub>
| ''[[Metabotropic glutamate receptor 5|GRM5]]''
| align="center" | 11q14.3
| Release of K<sup>+</sup> from the cell by activating K<sup>+</sup> ionic channels
|-
| rowspan="2" align="center" | 2
| mGluR<sub>2</sub>
| ''[[Metabotropic glutamate receptor 2|GRM2]]''
| align="center" | 3p21.2
| rowspan="2" | Inhibition of [[adenylyl cyclase]] causing shutdown of the [[cAMP-dependent pathway]]<br />And therefore decreasing amount of [[cyclic adenosine monophosphate|cAMP]]
|-
| mGluR<sub>3</sub>
| ''[[GRM3]]''
| align="center" | 7q21.1-q21.2
|-
| rowspan="4" align="center" | 3
| mGluR<sub>4</sub>
| ''[[Metabotropic glutamate receptor 4|GRM4]]''
| align="center" | 6p21.3
| rowspan="4" | Activation of Ca<sup>2+</sup> channels, allowing more Ca<sup>2+</sup> to enter the cell<ref name="con1">{{cite journal | author = Conn PJ et al. | title = Metabotropic glutamate receptors in the basal ganglia motor circuit | journal = Nature Reviews Neuroscience  | volume = 6 | issue = 10 | pages = 787–98 | year = 2005 | pmid = 16276355 | doi = 10.1038/nrn1763}}</ref>
|-
| mGluR<sub>6</sub>
| ''[[Metabotropic glutamate receptor 6|GRM6]]''
| align="center" | 5q35
|-
| mGluR<sub>7</sub>
| ''[[Metabotropic glutamate receptor 7|GRM7]]''
| align="center" | 3p26-p25
|-
| mGluR<sub>8</sub>
| ''[[Metabotropic glutamate receptor 8|GRM8]]''
| align="center" | 7q31.3-q32.1
|}


==関連項目==
==関連項目==