Sonic hedgehog (Q14860215)

From Wikidata
Jump to navigation Jump to search
mammalian protein found in Mus musculus
  • HHG-1
  • short digits
  • hemimelic extra toes
  • sonic hedgehog protein
  • Shh
  • shh unprocessed N-terminal signaling and C-terminal autoprocessing domains
edit
Language Label Description Also known as
English
Sonic hedgehog
mammalian protein found in Mus musculus
  • HHG-1
  • short digits
  • hemimelic extra toes
  • sonic hedgehog protein
  • Shh
  • shh unprocessed N-terminal signaling and C-terminal autoprocessing domains

Statements

molecular function
protein binding
determination method
IDA
IPI
11 references
retrieved
8 April 2019
stated in
A sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1
GOA
curator
UniProt
UniProt protein ID
Q62226
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog
GOA
curator
UniProt
UniProt protein ID
Q62226
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Megalin functions as an endocytic sonic hedgehog receptor
GOA
curator
UniProt
UniProt protein ID
Q62226
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
GOA
curator
The Roslin Institute
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Boc is a receptor for sonic hedgehog in the guidance of commissural axons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Glypican-3 inhibits Hedgehog signaling during development by competing with patched for Hedgehog binding
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
All Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved Manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IPI
retrieved
8 April 2019
stated in
The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
cell component
biological process
lung development
determination method
IGI
IMP
7 references
stated in
UniProt
UniProt protein ID
Q62226
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Sonic hedgehog is essential to foregut development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Sonic hedgehog regulates branching morphogenesis in the mammalian lung
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
embryonic digit morphogenesis
determination method
IGI
IMP
6 references
stated in
UniProt
UniProt protein ID
Q62226
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
GOA
curator
The Roslin Institute
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Gas1 extends the range of Hedgehog action by facilitating its signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
regulation of gene expression
determination method
IDA
IGI
IMP
ISO
6 references
stated in
UniProt
UniProt protein ID
Q62226
retrieved
9 August 2016
language of work or name
English
retrieved
14 February 2019
stated in
A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
ISO
retrieved
14 February 2019
stated in
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
14 February 2019
stated in
Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
14 February 2019
stated in
Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
14 February 2019
stated in
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
positive regulation of cell population proliferation
determination method
IDA
IGI
IEA
IMP
ISO
10 references
stated in
UniProt
UniProt protein ID
Q62226
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
ISO
retrieved
8 April 2019
stated in
Shh controls epithelial proliferation via independent pathways that converge on N-Myc
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Shh controls epithelial proliferation via independent pathways that converge on N-Myc
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IEA
retrieved
8 April 2019
stated in
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IMP
14 references
stated in
UniProt
UniProt protein ID
Q62226
retrieved
9 August 2016
language of work or name
English
retrieved
8 April 2019
stated in
Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Sonic hedgehog is essential to foregut development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
smoothened signaling pathway
determination method
IBA
IDA
IEA
IGI
IMP
6 references
retrieved
8 April 2019
stated in
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Hedgehog-regulated localization of Vax2 controls eye development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IEA
retrieved
8 April 2019
stated in
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Disruption of Scube2 Impairs Endochondral Bone Formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IBA
regulation of gene expression
determination method
IBA
IDA
IGI
IMP
ISO
6 references
retrieved
8 April 2019
stated in
A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
ISO
retrieved
8 April 2019
stated in
Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IMP
retrieved
8 April 2019
stated in
Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IGI
retrieved
8 April 2019
stated in
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62226
determination method
IBA

Identifiers

 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q14860215&oldid=2023059308"