9,444
回編集
細編集の要約なし |
細編集の要約なし |
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1行目: | 1行目: | ||
{| style="width: 619px; height: 1446px | {| style="width: 619px; height: 1446px" border="1" cellspacing="1" cellpadding="1" | ||
|+ 表1 主なS-パルミトイル化タンパク質<br> | |+ 表1 主なS-パルミトイル化タンパク質<br> | ||
{| style="width: 587px; height: 457px | {| style="width: 587px; height: 457px" border="1" cellspacing="1" cellpadding="1" | ||
|- | |- | ||
| ファミリー<br> | | ファミリー<br> | ||
| 主な例<br> | | 主な例<br> | ||
|- | |- | ||
| '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br> | | '''Signalling protein'''<br> Small GTPase<br> Gα subunit<br> Src family<br> Others<br> | ||
| <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br> | | <br>H-Ras, N-Ras,R-Ras, RhoB, Cdc42 isoform 2, Rab10<br>Gαs, Gαq, Gαi2<br>Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk<br>GAP43, eNOS, Paraleminin, Huntingtin, GAD65, Stathmin2<br> | ||
|- | |- | ||
| | | | ||
'''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br> | '''Transmembrane'''<br> Ion channel<br> GPCR<br> Cell adhesion molecule<br> Transporter<br> Matrix metalloproteinase<br> Myelin associated<br> Secretase<br> Cell death signalling<br> | ||
| GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR | | GluR1/2, GABAA γ2, Aquaporin 4, Kv1.1<br>Rhodopsin, β2-adrenergic receptor, <br>Integrin α6, CD4, CD8, CD9, NCAM140, Neurofascin, DCC<br>EAAT1, EAAT3<br>MT1-MMP<br>PLP, GPM6A<br>β-secretase, Nicastrin<br>Fas, NGFR | ||
|- | |- | ||
| '''Adaptor, Scaffold'''<br> | | '''Adaptor, Scaffold'''<br> | ||
| PSD95, PSD93α/β, GRIP1/2, Delphilin<br> | | PSD95, PSD93α/β, GRIP1/2, Delphilin<br> | ||
|- | |- | ||
| '''Viral protein'''<br> | | '''Viral protein'''<br> | ||
| Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br> | | Influenza HA H1 subunit, Sindbis virus E2 protein, HIV-1 gp160<br> | ||
|- | |- | ||
| '''N-palmitoylated protein'''<br> | | '''N-palmitoylated protein'''<br> | ||
| Sonic Hedgehog, Wnt, Ghrelin <br> | | Sonic Hedgehog, Wnt, Ghrelin <br> | ||
|} | |} | ||
<br> | <br> | ||
<br> | <br> | ||
表2 パルミチルトランスフェラーゼ | 表2 パルミチルトランスフェラーゼ | ||
<br> | |||
41行目: | 43行目: | ||
| DHHC1 | | DHHC1 | ||
| ZDHHC1 | | ZDHHC1 | ||
| <br> | | <br> | ||
| ER | | ER | ||
| <br> | | <br> | ||
47行目: | 49行目: | ||
| DHHC2 | | DHHC2 | ||
| ZDHHC2 | | ZDHHC2 | ||
| PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br> | | PSD95, SNAP25, eNOS, Nde1, CD151, ABC transporter A1<br> | ||
| ER/ゴルジ体<br> | | ER/ゴルジ体<br> | ||
| 癌<br> | | 癌<br> | ||
|- | |- | ||
| DHHC3<br> | | DHHC3<br> | ||
| | | | ||
ZDHHC3 | ZDHHC3 | ||
GODZ<br> | GODZ<br> | ||
| PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br> | | PSD95, SNAP25, Gαs, GABAAγ2, eNOS,<br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC4<br> | | DHHC4<br> | ||
| ZDHHC4<br> | | ZDHHC4<br> | ||
| BACE1<br> | | BACE1<br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC5<br> | | DHHC5<br> | ||
| ZDHHC5<br> | | ZDHHC5<br> | ||
| STREX<br> | | STREX<br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC6<br> | | DHHC6<br> | ||
| ZDHHC6<br> | | ZDHHC6<br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC7<br> | | DHHC7<br> | ||
| ZDHHC7<br> | | ZDHHC7<br> | ||
| PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br> | | PSD95, SNAP25, Gαs, GAP43, GABAAγ2, eNOS<br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC8<br> | | DHHC8<br> | ||
| ZDHHC8<br> | | ZDHHC8<br> | ||
| PSD95, SNAP25, eNOS, paralemmin-1<br> | | PSD95, SNAP25, eNOS, paralemmin-1<br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| 統合失調症<br> | | 統合失調症<br> | ||
|- | |- | ||
| DHHC9'''<br>''' | | DHHC9'''<br>''' | ||
| ZDHHC9<br> | | ZDHHC9<br> | ||
| H-RAS, N-Ras<br> | | H-RAS, N-Ras<br> | ||
| ER/ゴルジ体<br> | | ER/ゴルジ体<br> | ||
| 癌、X連鎖神経遅滞<br> | | 癌、X連鎖神経遅滞<br> | ||
|- | |- | ||
| DHHC10<br> | | DHHC10<br> | ||
| ZDHHC11<br> | | ZDHHC11<br> | ||
| <br> | | <br> | ||
| ER<br> | | ER<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC11<br> | | DHHC11<br> | ||
| ZDHHC23<br>NIDD<br> | | ZDHHC23<br>NIDD<br> | ||
| <br> | | <br> | ||
| ER<br> | | ER<br> | ||
| 癌<br> | | 癌<br> | ||
|- | |- | ||
| DHHC12<br> | | DHHC12<br> | ||
| ZDHHC12<br> | | ZDHHC12<br> | ||
| ABC transporter A1<br> | | ABC transporter A1<br> | ||
| ER/ゴルジ体<br> | | ER/ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC13<br> | | DHHC13<br> | ||
| ZDHHC24<br> | | ZDHHC24<br> | ||
| huntingtin<br> | | huntingtin<br> | ||
| ER<br> | | ER<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC14<br> | | DHHC14<br> | ||
| ZDHHC14<br> | | ZDHHC14<br> | ||
| <br> | | <br> | ||
| ER<br> | | ER<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC15<br> | | DHHC15<br> | ||
| ZDHHC15<br> | | ZDHHC15<br> | ||
| PSD95, GAP43, GABAAγ2, BACE1, CD151<br> | | PSD95, GAP43, GABAAγ2, BACE1, CD151<br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| X連鎖神経遅滞<br> | | X連鎖神経遅滞<br> | ||
|- | |- | ||
| DHHC16<br> | | DHHC16<br> | ||
| ZDHHC16<br> | | ZDHHC16<br> | ||
| <br> | | <br> | ||
| ER<br> | | ER<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC17<br> | | DHHC17<br> | ||
| | | | ||
ZDHHC17 | ZDHHC17 | ||
HIP14<br> | HIP14<br> | ||
| SNAP25, huntingtin, <br> | | SNAP25, huntingtin, <br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| ハンチントン病、癌<br> | | ハンチントン病、癌<br> | ||
|- | |- | ||
| DHHC18<br> | | DHHC18<br> | ||
| ZDHHC18<br> | | ZDHHC18<br> | ||
| <br> | | <br> | ||
| ゴルジ体<br> | | ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC19<br> | | DHHC19<br> | ||
| ZDHHC19<br> | | ZDHHC19<br> | ||
| R-Ras<br> | | R-Ras<br> | ||
| ER<br> | | ER<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC20<br> | | DHHC20<br> | ||
| ZDHHC20<br> | | ZDHHC20<br> | ||
| BACE1, ABC transporter 1<br> | | BACE1, ABC transporter 1<br> | ||
| 細胞膜<br> | | 細胞膜<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC21<br> | | DHHC21<br> | ||
| ZDHHC21<br> | | ZDHHC21<br> | ||
| eNOS, Lck, Fyn, ABC transporter 1<br> | | eNOS, Lck, Fyn, ABC transporter 1<br> | ||
| 細胞膜<br> | | 細胞膜<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC22<br> | | DHHC22<br> | ||
| ZDHHC13<br> | | ZDHHC13<br> | ||
| <br> | | <br> | ||
| ER/ゴルジ体<br> | | ER/ゴルジ体<br> | ||
| <br> | | <br> | ||
|- | |- | ||
| DHHC23<br> | | DHHC23<br> | ||
| ZDHHC25<br> | | ZDHHC25<br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
|- | |- | ||
| <br> | | <br> | ||
| ZDHHC22<br> | | ZDHHC22<br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
| <br> | | <br> | ||
|} | |} | ||
<br> | <br> | ||
{| style="width: 618px; height: 1074px" border="1" cellspacing="1" cellpadding="1" width="618" | |||
|- | |||
| Category | |||
| Family | |||
| N-Myristoylated protein | |||
|- | |||
| Kinase/Phosphatase | |||
| Src family kinase | |||
| Src, Yes, Fyn, Lyn, Lck, Hcr, Fgr, Yrk, Blk | |||
|- | |||
| | |||
| Abl tyrosine kinase | |||
| c-Abl, Arg | |||
|- | |||
| <br> | |||
| Ser/Thr kinase | |||
| cAMP-dependent protein kinase, AKAP18 | |||
|- | |||
| <br> | |||
| phosphatase | |||
| Calcineurin B | |||
|- | |||
| GTP-binding protein | |||
| Gα | |||
| Gα i1, Gαo, Gαt, Gαx | |||
|- | |||
| | |||
| ADP-ribosylation factor | |||
| Arf-1, Arf-3, Arf-5, Arf-6 | |||
|- | |||
| Ca2+ binding /<br>EF hand protein | |||
| | |||
| Recoverin, Neurocalcin, Aplycalcin, P22, NAP-22,<br>Hippocalcin, GCAP1, GCAP2, S-Modulin, Rem-1 | |||
|- | |||
| Membrane/cytoskeletal-<br>bound protein | |||
| | |||
| MARCKS, Annexin XIII, <br>Rapsyn, Pallidin, Hisactophilin 2 | |||
|- | |||
| Viral protein | |||
| Gag protein | |||
| HIV-1, Moloney murine, sarcoma virus, Friend murine,<br>leukemia virus | |||
|- | |||
| | |||
| Others | |||
| HIV-1 Nef, Duck hepatitis B virus, Rhinovirus 16,<br>Herpes simplex virus | |||
|- | |||
| Others | |||
| | |||
| eNOS | |||
|- | |||
| Caspase-cleavage <br>post-translational<br>N-myristoylated protein | |||
| | |||
| β-actin, BID, Gelsolin, PAK2, p28 Bap31, CD-IC2A, GCL,<br>MST3, PKC, | |||
|} |