| <div>DPC | 5-8 | Br- > Cl- > I- | 嚢胞性線維症 |- | CLCA | タルニフルメート<br>ジチオスレイトール<br>DIDS<br>ニフルミン酸 </div><div><br></div> <div>タモキシフェン | 1-10 | I- > Br- > Cl- | |- | CLC | 9ACCPP</div><div><br></div><div><br></div><div><br></div><div><br>クロロトキシン<br>ジフェニルホスフィン酸クロリド<br>DIDS<br>IAA-94<br>NPPB<br>ニフルミン酸<br>タモキシフェン | 1-9 | Cl- > Br- > I- | CLCN1:筋強直症</div><div><br>CLCN2:若年性ミオクロニーてんかん<br>CLCNKB:バーター症候群<br>CLCN5:遺伝性腎疾患(Dent病、低リン血症性くる病、X染色体連鎖劣性腎結石症)<br>CLCN7:大理石骨病 |- | VSOR塩素チャネル | DCPIB<br>DNDS<br>DIDS<br>NPPB<br>SITS<br>タモキシフェン | | I- > Cl- | |} ※ 注釈 9AC:9-アントラセンカルボン酸 (9-anthracene-carboxylic acid) CPP:3-(4-クロロフェノキシ)プロパン酸 (p-chlorophenoxy-propionic acid) DCPIB:4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid DIDS:4,4-ジイソチオシアナトスチルベン-2,2-ジスルホン酸, 二ナトリウム塩(4,4′-Diisothiocyanatostilbene-2,2′-disulfonic acid disodium salt hydrate) DNDS:4,4'-ジニトロスチルベン-2,2'-ジスルホン酸二ナトリウム(4,4'-dinitrostilbene-2,2'-disulfonate) NPPB:2-[(3-フェニルプロピル)アミノ]-5-ニトロ安息香 (Nitro-2-(3-phenylpropylamino)benzoic acid) SITS:4-アセチルアミノ-4'-イソチオシアナトスチルベン-2,2'-ジスルホン酸ジナトリウム(4-Acetamido-4′-isothiocyanato-2,2′-stilbenedisulfonic acid disodium salt hydrate) THIP:4,5,6,7-テトラヒドロイソオキサゾロ[5,4-c]ピリジン-3(2H)-オン•塩酸塩(4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride) TPMPA:(1,2,5,6-テトラヒドロピリジン-4-イル)メチルホスフィン酸((1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid) <br>参考文献 <ref>Clayton GH, Staley KJ, Wilcox CL, Owens GC and Smith RL (1998) Developmental expression of ClC-2 in the rat nervous system. Dev Brain Res 108: 307-318</ref><ref>Duran C, Thompson CH, Xiao Q and Hartzell HC (2010) Chloride channels: often enigmatic, rarely predictable. Annu Rev Physiol 72: 95-121</ref><ref>Jentsch TJ, Steinmeyer K and Schwarz G. (1990) Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes. Nature 348: 510-4</ref><ref>Jentsch TJ (2008) CLC chloride channels and transporters: from genes to protein structure, pathology and physiology. Crit Rev Biochem Mol Biol 43: 3-36</ref><ref>Kawasaki M, Uchida S, Monkawa T, Miyawaki A, Mikoshiba K, Marumo F and Sasaki S (1994) Cloning and expression of a protein kinase C-regulated chloride channel abundantly expressed in rat brain neuronal cells. Neuron 12: 597-604.</ref><ref>Lee S, Yoon BE, Berglund K, Oh SJ, Park H, Shin HS, Augustine GJ and Lee CJ. (2010) Channel-mediated tonic GABA release from glia. Science 330: 790-6</ref><ref>Okada Y, Sato K, and Numata T (2009) Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel J Physiol 587: 2141-2149</ref><ref>Piirsoo M, Meijer D and Timmusk T (2009) Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system. BMC Dev Biol 9:10</ref><ref>Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J and Zhao H. (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A 106: 11776-81</ref><ref>Verkman AS and Galietta LJV (2009) Chloride channels as drug targets. Nat Rev Drug Discov 8: 153-171</ref><ref>Wang XQ, Deriy LV, Foss S, Huang P, Lamb FS, Kaetzel MA, Bindokas V, Marks JD and Nelson DJ. (2006) CLC-3 channels modulate excitatory synaptic transmission in hippocampal neurons. Neuron 52: 321-33</ref><references /> </div>
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