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ネプリライシン (ソースを閲覧)

2013年3月27日 (水) 09:06時点における版

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'''1.ネプリライシンとは'''
'''1.ネプリライシンとは'''
ネプリライシンは活性部位が存在するカルボキシル末端側は管腔側/細胞外に配向するⅡ型の膜貫通型ペプチダーゼである。活性中心にZn結合モチ−フ(HEXXH配列)を有することから、メタロペプチダ−ゼに分類される[1][2]。別名として、エンケファリナーゼ、中性エンドペプチダーゼ24.11、CD10、membrane metallo-endopeptidase、common acute lymphoblastic leukemia antigen (CALLA)とも呼ばれている。プロテアーゼのM13ファミリーのMA(E)クランに分類される。脊椎動物に広く分類し、バクテリア由来のサーモライシンと高い相同性を示す[1][2]。
ネプリライシンは活性部位が存在するカルボキシル末端側は管腔側/細胞外に配向するⅡ型の膜貫通型ペプチダーゼである。活性中心にZn結合モチ−フ(HEXXH配列)を有することから、メタロペプチダ−ゼに分類される<ref><pubmed> 8475170 </pubmed></ref>[1][2]。別名として、エンケファリナーゼ、中性エンドペプチダーゼ24.11、CD10、membrane metallo-endopeptidase、common acute lymphoblastic leukemia antigen (CALLA)とも呼ばれている。プロテアーゼのM13ファミリーのMA(E)クランに分類される。脊椎動物に広く分類し、バクテリア由来のサーモライシンと高い相同性を示す[1][2]。


'''2.構造とサブファミリー'''
'''2.構造とサブファミリー'''
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'''8. 参考文献'''
'''8. 参考文献'''
<references />
<references />
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脚注1エンドトキシ（内毒素）：グラム陰性菌の外膜に存在する耐熱性の毒素．糖脂質と糖鎖からなるリポ多糖で,免疫系などに作用してマクロファージや好中球を活性化してサイトカインなどの炎症性因子の放出を促す．
脚注1エンドトキシ（内毒素）：グラム陰性菌の外膜に存在する耐熱性の毒素．糖脂質と糖鎖からなるリポ多糖で,免疫系などに作用してマクロファージや好中球を活性化してサイトカインなどの炎症性因子の放出を促す．
Nobuhisaiwata
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