16,039
回編集
細編集の要約なし |
細編集の要約なし |
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1行目: | 1行目: | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ | |+チロシンキナーゼ | ||
!colspan="3" |[[受容体チロシンキナーゼ]] (EC 2.7.10.2) | |||
|- | |||
!rowspan="7"| [[成長因子受容体]] | !rowspan="7"| [[成長因子受容体]] | ||
||[[ErbB| | ||[[ErbB|上皮成長因子受容体ファミリー]]||[[上皮成長因子受容体|EGFR]], [[HER2/neu|ERBB2]], [[ERBB3]], [[ERBB4]] | ||
|- | |- | ||
|[[ | |[[Insulin受容体]]ファミリー||[[Insulin-like growth factor 1受容体|IGF1R]], [[Insulin受容体|INSR]], [[INSRR]] | ||
|- | |- | ||
|[[RTK class III| | |[[RTK class III|PDGF受容体ファミリー]]|| [[Colony stimulating factor 1受容体|CSF1R]], [[CD135|FLT3]], [[CD117|KIT]], [[platelet-derived growth factor受容体|PDGFR]] ([[PDGFRA]], [[PDGFRB]]) | ||
|- | |- | ||
|[[Fibroblast growth | |[[Fibroblast growth factor受容体|FGF受容体]]ファミリー | ||
|[[Fibroblast growth | |[[Fibroblast growth factor受容体 1|FGFR1]], [[Fibroblast growth factor受容体 2|FGFR2]], [[Fibroblast growth factor受容体 3|FGFR3]], [[Fibroblast growth factor受容体 4|FGFR4]] | ||
|- | |- | ||
| [[ | | [[VEGF受容体s]]ファミリー | ||
| [[FLT1|VEGFR1]], [[Kinase insert | | [[FLT1|VEGFR1]], [[Kinase insert domain受容体|VEGFR2]], [[VEGFR3]], [[VEGFR4]] | ||
|- | |- | ||
| [[C-Met| | | [[C-Met|HGF受容体]]ファミリー | ||
|[[C-Met|MET]], [[MST1R|RON]] | |[[C-Met|MET]], [[MST1R|RON]] | ||
|- | |- | ||
| [[ | | [[Trk受容体]]ファミリー | ||
|[[ | |[[TrkA受容体|NTRK1]], [[NTRK2]], [[NTRK3]] | ||
|- | |- | ||
!colspan="2"|[[ | !colspan="2"|[[Ephrin受容体|EPH受容体]]ファミリー | ||
|[[ | |[[EPH受容体 A1|EPHA1]], [[EPH受容体 A2|EPHA2]], [[EPH受容体 A3|EPHA3]], [[EPH受容体 A4|EPHA4]], [[EPH受容体 A5|EPHA5]], [[EPHA6]], [[EPHA7]], [[EPHA8]], [[EPH受容体 B1|EPHB1]], [[EPH受容体 B2|EPHB2]], [[EPHB3]], [[EPH受容体 B4|EPHB4]], [[EPHB5]], [[EPHB6]], [[EPHX]] | ||
|- | |- | ||
!colspan="2"|[[ | !colspan="2"|[[Leukocyte受容体 チロシンキナーゼ|LTK受容体]]ファミリー | ||
| | |[[Leukocyte受容体 チロシンキナーゼ|LTK]], [[Anaplastic lymphoma kinase|ALK]] | ||
|- | |- | ||
!colspan="2"|[[ | !colspan="2"|[[Angiopoietin受容体|TIE受容体]]ファミリー | ||
|[[TIE1|TIE]], [[TEK | |[[TIE1|TIE]], [[TEK チロシンキナーゼ|TEK]] | ||
|- | |- | ||
!colspan="2"|[[ | !colspan="2"|[[受容体チロシンキナーゼ様オーファン受容体|ROR受容体]]ファミリー | ||
|[[ROR1]], [[ROR2]] | |[[ROR1]], [[ROR2]] | ||
|- | |- | ||
!colspan="2"| [[DDR1| | !colspan="2"| [[DDR1|DDR受容体]]ファミリー | ||
| | |[[DDR1]], [[Discoidin domain-containing受容体 2|DDR2]] | ||
|- | |- | ||
!colspan="2"| [[PTK7| | !colspan="2"| [[PTK7|PTK7受容体]]ファミリー | ||
|[[PTK7]] | |[[PTK7]] | ||
|- | |- | ||
!colspan="2"|[[related | !colspan="2"|[[related to受容体 チロシンキナーゼ|RYK受容体]]ファミリー | ||
|[[related | |[[related to受容体 チロシンキナーゼ|RYK]] | ||
|- | |- | ||
!colspan="2"|[[MuSK protein| | !colspan="2"|[[MuSK protein|MuSK受容体]]ファミリー | ||
|[[MuSK protein|MUSK]] | |[[MuSK protein|MUSK]] | ||
|- | |- | ||
!colspan="2"|[[ROS1 (gene)| | !colspan="2"|[[ROS1 (gene)|ROS受容体]]ファミリー | ||
|[[ROS1 (gene)|ROS1]] | |[[ROS1 (gene)|ROS1]] | ||
|- | |- | ||
!colspan="2"|[[AATK| | !colspan="2"|[[AATK|AATYK受容体]]ファミリー | ||
|[[AATK|AATYK]], [[LMTK2|AATYK2]], [[AATYK3]] | |[[AATK|AATYK]], [[LMTK2|AATYK2]], [[AATYK3]] | ||
|- | |- | ||
!colspan="2"| [[ | !colspan="2"| [[AXL受容体 チロシンキナーゼ|AXL受容体]]ファミリー | ||
| [[ | | [[AXL受容体 チロシンキナーゼ|AXL]], [[MERTK|MER]], [[TYRO3]] | ||
|- | |- | ||
!colspan="2"|[[RET proto-oncogene| | !colspan="2"|[[RET proto-oncogene|RET受容体]]ファミリー | ||
|[[RET proto-oncogene|RET]] | |[[RET proto-oncogene|RET]] | ||
|- | |- | ||
59行目: | 61行目: | ||
|[[STYK1]] | |[[STYK1]] | ||
|- | |- | ||
!colspan="3" |[[Non- | !colspan="3" |[[Non-受容体 チロシンキナーゼ]]s (EC 2.7.10.2) | ||
|- | |- | ||
|[[Abl gene|ABL]] | !colspan="2"|[[Abl gene|ABL]]ファミリー | ||
| [[Abl gene|ABL1]], [[ABL2|ARG]] | | [[Abl gene|ABL1]], [[ABL2|ARG]] | ||
|- | |- | ||
|[[TNK2|ACK]] | !colspan="2"|[[TNK2|ACK]]ファミリー | ||
|[[TNK2|ACK1]], [[TNK1]] | |[[TNK2|ACK1]], [[TNK1]] | ||
|- | |- | ||
|[[C-src | !colspan="2"|[[C-src チロシンキナーゼ|CSK]]ファミリー | ||
| [[C-src | | [[C-src チロシンキナーゼ|CSK]], [[Megakaryocyte-associated チロシンキナーゼ|MATK]] | ||
|- | |- | ||
| [[PTK2|FAK]] | !colspan="2"| [[PTK2|FAK]]ファミリー | ||
| [[PTK2|FAK]], [[PTK2B|PYK2]] | | [[PTK2|FAK]], [[PTK2B|PYK2]] | ||
|- | |- | ||
| [[Feline sarcoma oncogene|FES]] | !colspan="2"| [[Feline sarcoma oncogene|FES]]ファミリー | ||
|[[Feline sarcoma oncogene|FES]], [[FER (gene)|FER]] | |[[Feline sarcoma oncogene|FES]], [[FER (gene)|FER]] | ||
|- | |- | ||
| [[Fyn-related kinase|FRK]] | !colspan="2"| [[Fyn-related kinase|FRK]]ファミリー | ||
| [[Fyn-related kinase|FRK]], [[PTK6|BRK]], [[SRMS (gene)|SRMS]] | | [[Fyn-related kinase|FRK]], [[PTK6|BRK]], [[SRMS (gene)|SRMS]] | ||
|- | |- | ||
|[[Janus kinase|JAK]] | !colspan="2"|[[Janus kinase|JAK]]ファミリー | ||
|[[Janus kinase 1|JAK1]], [[Janus kinase 2|JAK2]], [[Janus kinase 3|JAK3]], [[ | |[[Janus kinase 1|JAK1]], [[Janus kinase 2|JAK2]], [[Janus kinase 3|JAK3]], [[チロシンキナーゼ 2|TYK2]] | ||
|- | |- | ||
|[[SRC-A]] | !colspan="2"|[[SRC-A]]ファミリー | ||
|[[Src (gene)|SRC]], [[FGR (gene)|FGR]], [[FYN]], [[YES1]] | |[[Src (gene)|SRC]], [[FGR (gene)|FGR]], [[FYN]], [[YES1]] | ||
|- | |- | ||
|[[SRC-B]] | !colspan="2"|[[SRC-B]]ファミリー | ||
|[[Tyrosine-protein kinase BLK|BLK]], [[HCK]], [[Lck|LCK]] | |[[Tyrosine-protein kinase BLK|BLK]], [[HCK]], [[Lck|LCK]], [[LYN]] | ||
, [[LYN]] | |||
|- | |- | ||
|[[TEC (gene)|TEC]] | !colspan="2"|[[TEC (gene)|TEC]]ファミリー | ||
|[[TEC (gene)|TEC]], [[BMX (gene)|BMX]], [[Bruton's | |[[TEC (gene)|TEC]], [[BMX (gene)|BMX]], [[Bruton's チロシンキナーゼ|BTK]], [[ITK (gene)|ITK]], [[TXK (gene)|TXK]] | ||
|- | |- | ||
|[[Syk|SYK]] | !colspan="2"|[[Syk|SYK]]ファミリー | ||
|[[Syk|SYK]], [[ZAP-70|ZAP70]] | |[[Syk|SYK]], [[ZAP-70|ZAP70]] | ||
} | |} |